Global dengue epidemiology trends

Ferreira, Gabriela B

doi:10.1590/s0036-46652012000700003

Cited by 80 publications

(82 citation statements)

References 7 publications

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“…The patient develops hemorrhagic manifestations such as red or purple spot on skin and bleeding through the nose, gastrointestinal tract and gums. Other symptoms have also been reported in the literature, which include encephalitis, encephalopathy, myocarditis, hepatitis and cholecystitis [5].…”

Section: Brief Review Of Dengue Fevermentioning

confidence: 85%

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Carica Papaya; A Paired and Alternative Therapy of Dengue Fever

Nesar

Omer

Rizvi

et al. 2018

JBT

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The purpose f the study is to explore the prospective use of Carica papaya leaves extracts for Dengue fever that is a painful, debilitating mosquito-borne disease caused by dengue viruses. An estimated 390 million dengue infections occur worldwide each year, with about 96 million resulting in illness. It has been found at height in developing nations like India, Pakistan, Sri Lanka and Bangladesh. Mostly tropical areas have been reported infected. The disease is transmitted by an Aedes mosquito infected with a dengue virus; interestingly it is not transferred from person to person. Symptoms are mild to serious including hemorrhagic fever; a rare complication characterized by high fever, damage to lymph and blood vessels, bleeding from the nose and gums, enlargement of the liver, and failure of the circulatory system and it can cause the death. All the symptoms of disease are due to low platelets count that may become very low if not managed. Consequently, the research reveals that juice of the leaves of the Carica papaya plant from the family Caricaceae help to increase the platelet levels. The present review is done to enlighten the theory of the management of dengue through this alternative therapy that can be implement along with conventional treatment. The covered researches in present study would raise and support the possibility of being, the remedy and significant alternative in the prospect.

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Section: Brief Review Of Dengue Fevermentioning

confidence: 85%

“…Unfortunately, due to lack of adequate surveillance progamme in the underdeveloped and developing countries, the management of the disease is not known [5]. Carica papaya, an alternative herbal medicine being investigated to control the massive problem of dengue.…”

Section: Introductionmentioning

confidence: 99%

Carica Papaya; A Paired and Alternative Therapy of Dengue Fever

Nesar

Omer

Rizvi

et al. 2018

JBT

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“…In the Americas, almost all countries now have hyperendemicity despite the absence of dengue in the middle of the 20th century [3•]. In the US, small outbreaks have occurred in Hawaii, Texas and Florida [11]. In international travelers returning from dengue endemic countries, dengue is now the second most common cause of fever [12–14].…”

Section: Geographic and Numeric Expansion Of Denguementioning

confidence: 99%

Dengue: Challenges for Policy Makers and Vaccine Developers

Wilder‐Smith

MacAry

2014

Curr Infect Dis Rep

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Because of the increasing incidence, geographic expansion and economic burden of dengue transmission, dengue poses major challenges to policy makers. A vaccine against dengue is urgently needed, but vaccine development has been hampered by the lack of an appropriate animal model, poor understanding of correlates of successful human immunity, the fear of immune enhancement, and viral interference in tetravalent combinations. The most suitable target epitopes for vaccines, as well as the role of nonstructural proteins remain elusive. The chimeric yellow fever bone-based live attenuated dengue vaccine is furthest in development, but initial efficacy results have been disappointing. Lessons learnt from this failure will affect the design of future trials, and increase the urgency to identify the best epitope and immune correlates. Dengue vaccine introduction will not be the only strategy to combat dengue, but needs to be “packaged” with novel vector control approaches, with community-based interventions to reduce the number of breeding sites, and reducing the case fatality rate by improving case management.

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“…Today endemic in over 125 countries, it infects nearly 50-270 million people every year, resulting in a sizable number of deaths. [1] In fact, dengue appears to be overtaking malaria in terms of morbidity and economic impact of the disease. [2] Unfortunately, due to lack of adequate surveillance systems in the underdeveloped and developing countries, the exact extent of the problem is not known.…”

Section: Introductionmentioning

confidence: 99%

“…[2] Unfortunately, due to lack of adequate surveillance systems in the underdeveloped and developing countries, the exact extent of the problem is not known. [1] Travellers from non-endemic areas to the dengue-affected areas are also exposed to the possibility of infection. [3] This makes it an international public health concern, affecting individuals from countries even where the disease is not prevalent.…”

Section: Introductionmentioning

confidence: 99%

Papaya extract to treat dengue: A novel therapeutic option?

Sarala¹,

Paknikar²

2014

Ann Med Health Sci Res

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Dengue is a viral disease that today affects a vast number of people in over 125 countries and is responsible for a sizable number of deaths. In the absence of an effective antiviral drug to treat the disease, various treatments are being investigated. Studies have indicated that the juice of the leaves of the Carica papaya plant from the family Caricaceae could help to increase the platelet levels in these patients. This review describes some of the published studies on this topic. The search was done independently by the two authors using PubMed, Google and the library database and included relevant articles of the last 10 years. A total of 7 studies were included in this review, which were one animal study, one case report, three case series and two randomized controlled trials. Although many of the studies and case reports published in literature lack adequate information, some of the studies do raise the possibility that this treatment could be an important option in the future. Further large-scale studies could establish the usefulness or ineffectiveness of this natural product in the treatment of dengue.

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Global dengue epidemiology trends

Cited by 80 publications

References 7 publications

Carica Papaya; A Paired and Alternative Therapy of Dengue Fever

Carica Papaya; A Paired and Alternative Therapy of Dengue Fever

Dengue: Challenges for Policy Makers and Vaccine Developers

Papaya extract to treat dengue: A novel therapeutic option?

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