Acute respiratory viral infections in children in Rio de Janeiro and Teresópolis, Brazil

Albuquerque, Maria Carolina M.; Varella, Rafael Brandão; Santos, Norma

doi:10.1590/s0036-46652012000500003

Cited by 11 publications

(11 citation statements)

References 58 publications

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“…The months with the largest circulation of RSV (June 2010 and July 2010; data not shown) match those months where HRV was detected less frequently. Our findings are in line with observations in previous studies [Calvo Rey et al, ; Miller et al, ; Fry et al, ; Vidaurreta et al, ; Albuquerque et al, ; Bicer et al, ]. Differences are likely to exist in HRV seasonality depending on the year being surveyed.…”

Section: Discussionsupporting

confidence: 93%

“…Several research studies have measured HRV frequency in ARI hospitalized children, ranging from 16 to 57.8%. The 38.1% value from this study is within this range of values, considering PCR‐tested samples as a denominator [Calvo Rey et al, ; Miller et al, ; Fry et al, ; Iwane et al, ; Vidaurreta et al, ; Albuquerque et al, ; Huijskens et al, ; Marcone et al, ; Piñero Fernández et el., 2012; Bicer et al, ].…”

Section: Discussionsupporting

confidence: 56%

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The role of rhinovirus in children hospitalized for acute respiratory disease, Santa Fe, Argentina

Rudi¹,

Molina²,

Díaz³

et al. 2015

J. Med. Virol.

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Human rhinoviruses (HRVs) were historically considered upper airway pathogens. However, they have recently been proven to cause infections in the lower respiratory tract, resulting in hospitalization of children with pneumonia, bronchiolitis, and chronic pulmonary obstruction. In this report, HRV frequency and seasonality are described together with patient clinical-epidemiological aspects. From a total of 452 surveyed samples, the HRV nucleic acids was detected in 172 (38.1%) and found in every month of the study year. 60% of inpatients with acute respiratory infection (ARI) associated with HRV were under 6 months of age and 31% had a clinical history, being preterm birth and recurrent wheezing the prevailing conditions. The most frequent discharge diagnoses were pneumonia (35.2%), bronchiolitis (32.4%), and bronchitis (12.4%). Fifteen point nine percent of patients required admission into intensive care units. The results obtained in this study demonstrated the association between HRV and children hospitalizations caused by ARI.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 56%

The role of rhinovirus in children hospitalized for acute respiratory disease, Santa Fe, Argentina

Rudi¹,

Molina²,

Díaz³

et al. 2015

J. Med. Virol.

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“…Despite the fact that the local epidemiology of ARIs is modelled by herd immunity and environmental factors, the global picture of ARIs that arises from our study conforms with that observed in different regions of the world. In particular, the choice of the pathogens tested seems to be relevant since (i) the rate of elucidation is close to what is observed in France, using the same molecular assays (authors' personal data), (ii) peaks of detection match the ILI epidemiological peaks and (iii) in previous studies performed in Brazil, the different viruses identified in the current study were detected, confirming their circulation in the region [12][13][14][15][16]. The distribution of cases in age groups is also essentially similar with what was reported elsewhere, e.g., in Ecuador [8].…”

Section: Discussionsupporting

confidence: 76%

Viral aetiology influenza like illnesses in Santa Cruz, Bolivia (2010–2012)

Delangue

Sanchez

Piorkowski

et al. 2014

Virol J

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BackgroundAcute respiratory infections represent a serious public health issue worldwide but virological aetiologies of Influenza Like Illnesses (ILIs) remain largely unknown in developing countries. This study represents the first attempt to characterise viral aetiologies of ILIs in Bolivia.MethodsIt was performed in Santa Cruz city from January 2010 to September 2012, based on 564 naso-pharyngeal swabs collected in a National Reference Laboratory and real-time PCR techniques, viral cultures and phylogenetic analyses.Results50.2% of samples were positive for at least one virus with influenza viruses (Flu A: ~15%; Flu B: ~9%), rhinoviruses (~8%), coronaviruses (~5%) and hRSV (~4%) being the most frequently identified. The pattern of viral infections varied according to age groups. The elucidation rate was the highest (>60%) amongst patients under 10 yo and the lowest (<40%) amongst patients ≥60 yo. Nearly 3% of samples showed dual viral infections. Epidemiological peaks were associated with a predominant virus but generally included 30-50% of infections by different viruses. Unexpectedly, the frequency of influenza in the 0–4 yo population was very low and a complete hRSV eclipse occurred in 2011. Genetic analyses indicated that distinct evolutionary lineages of Flu A(H1N1)pdm2009, Flu A/H3N2 and Flu B have co-circulated in Bolivia in the study period, originating from Central and North America, Europe, Asia and Australia.ConclusionOur results emphasise the requirement for a reinforced epidemiological and genetic follow-up of influenza and other ILIs in Bolivia to further inform the preparation of vaccines used in the region, guide vaccination campaigns and improve the medical management of patients.

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“…Other studies have shown even greater incidence of HCoV infection, up to 12%. 2,8,10 Co-infection with HCoV was observed in 26.5% of samples, and HCoV had the second lowest rate of co-infection within the group of viruses studied, behind only influenza.…”

Section: Discussionmentioning

confidence: 95%

Human coronavirus and severe acute respiratory infection in Southern Brazil

Trombetta

Faggion

Leotte

et al. 2016

Pathogens and Global Health

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Human coronaviruses (HCoVs) are an important cause of respiratory tract infection and are responsible for causing the common cold in the general population. Thus, adequate surveillance of HCoV is essential. This study aimed to analyze the impact of HCoV infections and their relation to severe acute respiratory infection (SARI) in a hospitalized population in Southern Brazil. A cross-sectional study was conducted at a tertiary care hospital, and assessed inpatients under investigation for SARI by the hospital epidemiology department, and all patients who had nasopharyngeal aspirates collected from January 2012 to December 2013 to detect respiratory viruses (RVs). Viral infection was detected by multiplex reverse transcriptase polymerase chain reaction (RT-PCR), with primers specific to the subtypes HCoV-229E/NL63 and OC43/HKU1. The overall positivity rate was 58.8% (444/755), and HCoVs were detected in 7.6% (n = 34) of positive samples. Children below two years of age were most frequently affected (62%). Comorbidities were more likely to be associated with HCoVs than with other RVs. Immunosuppression was an independent risk factor for HCoV infection (OR = 3.5, 95% CI 1.6-7.6). Dyspnea was less frequently associated with HCoV infection (p < 0.001), and HCoV accounted for 6% of the SARI cases. Three patients infected with HCoV (9%) died from respiratory infection. HCoVs are important respiratory pathogens, especially in hospitalized children under 2 years of age and in immunosuppressed patients. They may account for a small proportion of SARI diagnoses, increased need for mechanical ventilation, intensive care unit admission, and death.

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Acute respiratory viral infections in children in Rio de Janeiro and Teresópolis, Brazil

Cited by 11 publications

References 58 publications

The role of rhinovirus in children hospitalized for acute respiratory disease, Santa Fe, Argentina

The role of rhinovirus in children hospitalized for acute respiratory disease, Santa Fe, Argentina

Viral aetiology influenza like illnesses in Santa Cruz, Bolivia (2010–2012)

Human coronavirus and severe acute respiratory infection in Southern Brazil

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