2010
DOI: 10.1590/s0036-46652010000500006
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Abstract: SUMMARYThere are few reports linking hyponatremia and visceral leishmaniasis (kala-azar). This is a study of 55 consecutive kala-azar patients and 20 normal individuals as a control group. Hyponatremia and serum hypo-osmolality were detected in 100% of kalaazar patients. High first morning urine osmolality (750.0 ± 52.0 vs. 894.5 ± 30.0mOsm/kg H 2 O, p < 0.05), and high 24-hour urine osmolality (426.0 ± 167.0 vs. 514.6 ± 132.0 mOsm/kg H 2 O, p < 0.05) demonstrated persistent antidiuretic hormone secretion. Uri… Show more

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Cited by 9 publications
(14 citation statements)
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“…The same result was reported by Frederico et al [51]. This increase in uric acid level which may refer to the physiological activity and the influence of destroyed or catabolism [52, 53]. Increased level of uric acid may contribute much more to scavenging of free radicals.…”
Section: Discussionsupporting
confidence: 77%
“…The same result was reported by Frederico et al [51]. This increase in uric acid level which may refer to the physiological activity and the influence of destroyed or catabolism [52, 53]. Increased level of uric acid may contribute much more to scavenging of free radicals.…”
Section: Discussionsupporting
confidence: 77%
“…Neither a significant difference nor correlation was reported between males (p>0.05), females (p>0.05) with positive anti-rK39 antibodies, and between males and females (p>0.05) with respect to serum T4 levels. These results are consistent with those of a study conducted in Sao Paulo, revealed that a normal free T4 plasma level indicates a sufficient thyroid hormone secretion for the basic needs of an organism in kala-azar patients, rejecting the possibility of thyroid hormone deficiency [20]. This supports our knowledge that continuous synthesis, storage, and release of T4 is dependent on the pulsatile stimulation of the thyroid by TSH (thyrotropin) and is a result of normal TSH levels in all patients included the in current study.…”
Section: Discussionsupporting
confidence: 92%
“…In the current study, both males and females with positive anti-rK39 antibodies have normal serum TSH and T3 levels. Neither significant differences nor correlation was present between males (p>0.05), females (p>0.05) with positive antirK39 antibodies, and between males and females (p>0.05) with respect to the serum TSH and T3 levels, which were in accordance with the report from Brazil that revealed normal TSH levels among patients positive for Kala-azar [20]. In the current study, both males and females with positive anti-rK39 antibodies had normal serum T4 levels.…”
Section: Discussionsupporting
confidence: 89%
“…However, it did not lead to important hemodynamic instability, since most of the patients did not present hypotension or other cardiovascular abnormality. This hypovolemic state may have contributed to hyponatremia development, due to vasopressin secretion, and stimulus of renin-angiotensin-aldosterone system, as suggested by others [ 3 ].…”
Section: Discussionmentioning
confidence: 90%
“…The Leishmania parasites escape the hosts’ immune response and cause a severe immune dysfunction, with polyclonal activation of B lymphocytes as well as cellular and humoral immunity impairment. During the progression of the disease, the parasites affect reticuloendothelial tissues and important organs, such as lymph nodes, bone marrow, liver, spleen, digestive system and kidneys [ 3 ]. This condition predominantly affects children and young adults, and may manifest as an oligosymptomatic infection with non-specific symptoms such as low fever, dry coughing, sweating and malaise, or as a life-threatening chronic condition with pancytopenia, hemorrhagic phenomena, hepatomegaly, splenomagly, hypoalbuminemia and elevated globulinemia [ 4 , 5 ].…”
Section: Introductionmentioning
confidence: 99%