2010
DOI: 10.1590/s0036-46652010000500002
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: This study was aimed to evaluate and compare the pathogenicity of rabies virus isolated from bats and dogs, and to verify the efficacy of a commercial rabies vaccine against these isolates. For evaluation of pathogenicity, mice were inoculated by the intramuscular route (IM) with 500MICLD₅₀/0.03 mL of the viruses. The cross-protection test was performed by vaccinating groups of mice by the subcutaneous route and challenged through the intracerebral (IC) route. Isolates were fully pathogenic when inoculated by … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

0
7
0

Year Published

2011
2011
2019
2019

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 11 publications
(7 citation statements)
references
References 30 publications
0
7
0
Order By: Relevance
“…Most pathogenicity studies were performed using RABV [51], demonstrating differences in virus characteristics depending on the isolates used [35, 36, 51]. Comparative analyses of different lyssavirus isolates within one species were also published for LBV, where distinct differences in pathogenicity between isolates were also recorded [34].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Most pathogenicity studies were performed using RABV [51], demonstrating differences in virus characteristics depending on the isolates used [35, 36, 51]. Comparative analyses of different lyssavirus isolates within one species were also published for LBV, where distinct differences in pathogenicity between isolates were also recorded [34].…”
Section: Discussionmentioning
confidence: 99%
“…However, differences in pathogenicity within other lyssavirus species had been observed, i.e. for Lagos bat virus (LBV) and Rabies virus (RABV) [3436]. Against this background and the conundrum of reduced pathogenicity in experimental animal studies on one side and human casualties on the other, this study aimed at analyzing different EBLV-1 isolates representing all three sublineages to assess variability in pathogenicity.…”
Section: Introductionmentioning
confidence: 99%
“…Bats are now the most prominent source of rabies for humans, domestic animals and wild animals in the Americas (Kuzmin and Rupprecht, 2007). Rabies is a complex problem with economic, public health and ecological implications (Cunha et al, 2010). Environmental changes due to urban development may have contributed to the increase in the bat population in urban areas, not only because of the wide variety of shelters but also due to the large food supply and absence of predators (Sodré et al, 2010).…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, street Rabies lyssavirus have distinct biological characteristics (e.g. virus ability to spread from cell to cell, virus internalization and virus replication in a tissue culture system) when compared with tissue culture-adapted strains [6,9,10]. Biochemical and biology investigation frequently require a large quantity of virus, such as viral replication, viral entry and viral spread techniques into host cells.…”
Section: Introductionmentioning
confidence: 99%