2009
DOI: 10.1590/s0036-46652009000400004
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Abstract: Limited and contradictory information exists regarding the prognosis of HIV/HTLV-I co-infection. Our goal was to estimate the effect of HTLV-I infection on mortality in HIV-infected patients at a HIV reference center in Peru. We studied a retrospective cohort of HIV-infected patients, who were exposed or unexposed to HTLV-I. Exposed patients were Western Blot (WB) positive for both retroviruses. Unexposed patients were WB positive for HIV, and had least one negative EIA for HTLV-I. These were selected among pa… Show more

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Cited by 6 publications
(7 citation statements)
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“…Survival was shorter for coinfected patients with detectable plasma viremia 6.7 ± 0.9 in comparison to those with undetectable viral load 11.0 ± 0.1 years ( p = 0.04) ( 26 ). ART use was less frequent on coinfected patients when compared to monoinfected ones as follows: 42 vs. 64%, ( p = 0.04) ( 24 ), 16/30 (53.3%) vs. 49/60 (81.6%) ( 20 ), 5 vs. 0% ( p = 0.58) ( 7 ), 44 vs. 53% ( p = 0.5) ( 22 ), but in two studies there was not statistical difference. In Zehender et al study no patient with peripheral polyneuropathy was on ART at the moment of symptoms onset ( 20 ).…”
Section: Resultsmentioning
confidence: 99%
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“…Survival was shorter for coinfected patients with detectable plasma viremia 6.7 ± 0.9 in comparison to those with undetectable viral load 11.0 ± 0.1 years ( p = 0.04) ( 26 ). ART use was less frequent on coinfected patients when compared to monoinfected ones as follows: 42 vs. 64%, ( p = 0.04) ( 24 ), 16/30 (53.3%) vs. 49/60 (81.6%) ( 20 ), 5 vs. 0% ( p = 0.58) ( 7 ), 44 vs. 53% ( p = 0.5) ( 22 ), but in two studies there was not statistical difference. In Zehender et al study no patient with peripheral polyneuropathy was on ART at the moment of symptoms onset ( 20 ).…”
Section: Resultsmentioning
confidence: 99%
“…Six articles describing survival were identified ( 8 , 11 , 15 , 22 , 23 , 26 ). Four showed lower survival rate for HIV-1 and HTLV-1 or HTLV-1/2 coinfected subjects ( 8 , 15 , 23 , 26 ), while the remaining studies found a neutral association between survival and HIV-1 and HTLV-2 coinfection status ( 11 , 22 ).…”
Section: Resultsmentioning
confidence: 99%
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“…HTLV-1 can be associated with significant increases in the CD4 cell count without immunologic benefit. The effects of co-infection have not been adequately studied, and conflicting reports exist as to whether co-infection affects mortality [44]. HTLV-1 co-infection should be considered in HIV-infected patients who present with OIs despite elevated CD4 counts.…”
Section: Virusesmentioning
confidence: 99%
“…Porém, a expressão do gene tax nem sempre é encontrada nas células de ATL (TAKEDA et al, 2004 -2 (LEWIS et al, 2002; -2c (ISHAK et al, 2003). Porém, sequências completas de nucleotídeos de vários genomas demonstraram que as cepas brasileiras do HTLV-2 são variantes moleculares do subtipo HTLV-2a (LEWIS et al, 2000;SHINDO et al, 2002; BRITES et al, 2001;COLLINS et al, 2009). Em relação à coinfecção HIV/HTLV-2 nenhuma evidência mostrou que pode haver uma rápida progressão para a Aids, pelo contrário, essa coinfecção pode gerar alguns efeitos protetores com base em estudos in vitro (BRITES et al, 2009;BARRIOS et al, 2013).…”
Section: Subtipos Viraisunclassified