Prevalence of hepatitis C virus infection in quilombo remnant communities in Central Brazil

Reis, N.R.S.; Motta-Castro, Ana Rita Coimbra; Silva, Ágabo M C; Teles, Sheila Araújo; Yoshida, Clara Fumiko Tachibana; Martins, Regina Maria Bringel

doi:10.1590/s0036-46652008000600010

Cited by 8 publications

(5 citation statements)

References 8 publications

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“…The proportion of confirmed active infections among positive screening test results varies widely across studies and test types. The proportion of RNA-positive, active HCV infection cases ranged from 0% to 89.7% among positive antibody-based assays [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][45][46][47][48][51][52][53][54] and from 0% to 100% among antigen-based assays. 39,44,49,50 Only three studies conducted confirmatory polymerase chain reaction on samples that tested negative for HCV antibody or antigen.…”

Section: Box 1: Grading Of Recommendationsmentioning

confidence: 99%

Recommendations on hepatitis C screening for adults

2017

CMAJ

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Section: Box 1: Grading Of Recommendationsmentioning

confidence: 99%

Recommendations on hepatitis C screening for adults

2017

CMAJ

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“…Six studies were found that reported the prevalence of antibodies to hepatitis C virus (anti-HCV), with a range of zero to 5.7% (three from Brazil (64, 71, 86) and one each from Colombia (79), Mexico (31), and Paraguay (84)). Overall, the prevalence of hepatitis C was low, apart from the studies in Colombia (prevalence of 5.7% in Amazonas) and Mexico (prevalence of 4.2% among indigenous peoples from 12 urban areas).…”

Section: Resultsmentioning

confidence: 99%

HIV, syphilis, and viral hepatitis among Latin American indigenous peoples and Afro-descendants: a systematic review

Russell

Nazar

Pino

et al. 2019

Rev Panam Salud Publica

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Objective To identify and summarize existing literature on the burden of HIV, sexually transmitted infections (STIs), and viral hepatitis (VH) in indigenous peoples and Afro-descendants in Latin America to provide a broad panorama of the quantitative data available and highlight problematic data gaps. Methods Published and grey literature were systematically reviewed to identify documents published in English, Spanish, or Portuguese with data collected between January 2000 and April 2016 on HIV, STI, and VH disease burden among indigenous peoples and Afro-descendants in 17 Latin American countries. Results Sixty-two documents from 12 countries were found. HIV prevalence was generally low (< 1%) but pockets of high prevalence (> 5%) were noted in some indigenous communities in Venezuela (Warao) (9.6%), Peru (Chayahuita) (7.5%), and Colombia (Wayuu females) (7.0%). High active syphilis prevalence (> 5%) was seen in some indigenous communities in Paraguay (11.6% and 9.7%) and Peru (Chayahuita) (6.3%). High endemicity (> 8%) of hepatitis B was found in some indigenous peoples in Mexico (Huichol) (9.4%) and Venezuela (Yanomami: 14.3%; Japreira: 29.5%) and among Afro-descendant quilombola populations in Brazil (Frechal: 12.5%; Furnas do Dionísio: 8.4% in 2008, 9.2% in 2003). Conclusions The gaps in existing data on the burden of HIV, STIs, and VH in indigenous peoples and Afro-descendants in Latin America highlight the need to 1) improve national surveillance, by systematically collecting and analyzing ethnicity variables, and implementing integrated biobehavioral studies using robust methodologies and culturally sensitive strategies; 2) develop a region-wide response policy that considers the needs of indigenous peoples and Afro-descendants; and 3) implement an intercultural approach to health and service delivery to eliminate health access barriers and improve health outcomes for these populations.

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“…In this area, there were indigenous, riverine and quilombo communities and recently almost one-third of the area was on fire. Reis et al [33] found 0.2% of anti-HCV prevalence among quilombo remnant communities in Midwest region of Brazil. The discrepancies in HCV prevalence and the impact of the fires that destroyed the environment reinforce the need for further epidemiological studies in this area.…”

Section: Discussionmentioning

confidence: 98%

Feasibility of dried blood spot for hepatitis C diagnosis in vulnerable subjects and people living in remote areas from Brazil

et al. 2022

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Background Agile, accessible and cheap diagnosis of hepatitis C virus (HCV) infection is essential to achieve the elimination of this infection, worldwide, as mandated by the World Health Organzation as part of its strategy for 2030. Dried blood spots (DBS) can be an attractive alternative for sample collection among people living in remote areas and vulnerable populations due to the less invasive collection, its biosafety, and storage & transportation of samples at room temperature. Design This study aims to estimate the usefulness of dried blood spot samples for the diagnosis and the assessment of HCV infection rates in three different settings in Brazil. Cross-sectional analysis of a sample collection from different populations, aiming to assess the performance of the testing algorithms and respective procedures among different populations with diverse background infection rates. Methods We reported the evaluation of DBS as alternative samples for detecting anti-HCV in different groups in real life conditions: (I) Vulnerable subjects living in remote areas of Southeast, North and Northeast Brazil (n = 1464); (II) Beauticians (n = 288); (III) People who use non-injectable drugs (n = 201); (IV) patients referred to outpatient care (n = 275). Results General assay accuracy was 99%, with a weighted kappa value of 0.9, showing an excellent performance. Sensitivities ranged from 87.5% to 100.0% between groups and specificities were above 99.2%. A total of 194 individuals had HCV RNA in serum and concordance of anti-HCV detection in DBS was 98.4%. Conclusions DBS samples could be used for anti-HCV detection in different populations recruited in real life conditions and ambulatory settings, with a high overall sensitivity and specificity.

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Prevalence of hepatitis C virus infection in quilombo remnant communities in Central Brazil

Cited by 8 publications

References 8 publications

Recommendations on hepatitis C screening for adults

Recommendations on hepatitis C screening for adults

HIV, syphilis, and viral hepatitis among Latin American indigenous peoples and Afro-descendants: a systematic review

Feasibility of dried blood spot for hepatitis C diagnosis in vulnerable subjects and people living in remote areas from Brazil

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