2008
DOI: 10.1590/s0036-46652008000100007
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Abstract: SUMMARYThe aim of this study was to assess the antioxidant and anti-schistosomal activities of the garlic extract (AGE) and Nigella sativa oil (NSO) on normal and Schistosoma mansoni-infected mice. AGE (125 mg kg -1 , i.p.) and NSO (0.2 mg kg -1 , i.p.) were administrated separately or in combination for successive 28 days, starting from the 1 st day post infection (pi). All mice were sacrificed at weeks 7 pi. Hematological and biochemical parameters including liver and kidney functions were measured to assess… Show more

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Cited by 120 publications
(86 citation statements)
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“…These results agree with those of El Shenawy et al [29] and Barros et al [30], who also observed that, after S. mansoni infection, elevation in protein and globulin (antibody) levels are associated with infection and liver dysfunction; hence globulin elevation represents a responsive mechanism enhancing the immunity of the host. The protein profile in S. mansoni infected mice pre-immunized by the three selected tegumental antigens recorded improvement in all fractions, where TX100-TA showed the highest enhanced level (Table 2 and Figure 1).…”
Section: Resultssupporting
confidence: 92%
“…These results agree with those of El Shenawy et al [29] and Barros et al [30], who also observed that, after S. mansoni infection, elevation in protein and globulin (antibody) levels are associated with infection and liver dysfunction; hence globulin elevation represents a responsive mechanism enhancing the immunity of the host. The protein profile in S. mansoni infected mice pre-immunized by the three selected tegumental antigens recorded improvement in all fractions, where TX100-TA showed the highest enhanced level (Table 2 and Figure 1).…”
Section: Resultssupporting
confidence: 92%
“…Result showed that, protection with AGE and NSO prevented most of the hematological and biochemical changes and markedly improved the antioxidant capacity of schistosomiasis mice compared to the infected-untreated ones. These results suggested that AGE and NSO may be promising agents to complement schistosomiasis specific treatment [36] .…”
Section: Anti-schistosomiasis Activitymentioning
confidence: 81%
“…Besides these effects, N. sativa also demonstrates antiparasitic effects. For instance, its administration decreases the number of eggs as well as worms in schistosomiasis, which tends to affect hepatic and intestinal tissues [11] . In addition, N. sativa attenuates the side effects associated with some common medications used by gastroenterologists.…”
Section: To the Editormentioning
confidence: 99%