Portal cd4+ and cd8+ t lymphocyte correlate to intensity of interface hepatitis in chronic hepatitis C

Viso, Ana Teresa Rodriguez; Barbosa, Thaís de Castro; Yamamoto, Lídia; Pagliari, Carla; Fernandes, Elaine Aparecida; Brasil, Roosecelis Araújo; Andrade, Heitor Franco de; Duarte, Maria Irma Seixas; Barone, Antonio

doi:10.1590/s0036-46652007000600007

Cited by 8 publications

(4 citation statements)

References 40 publications

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“…The CD4/CD8 lymphocyte ratio in blood is used in the diagnosis of HIV infection [8][9][10], evaluation of pathogenesis of HCV infection [11] and autoimmune disorders such as rheumatoid arthritis or vitiligo [12,13]. The present study aimed to evaluate changes in the numbers and proportions of the peripheral blood B, NK, T CD3 + , T CD4 + and T CD8 + lymphocyte subsets, and CD4/CD8 ratio following repeated intravenous cocaine administration in rats.…”

Section: Introductionmentioning

confidence: 99%

Cocaine administration increases CD4/CD8 lymphocyte ratio in peripheral blood despite lymphopenia and elevated corticosterone

Jankowski

Ignatowska‐Jankowska

Glac

et al. 2010

International Immunopharmacology

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Section: Introductionmentioning

confidence: 99%

Cocaine administration increases CD4/CD8 lymphocyte ratio in peripheral blood despite lymphopenia and elevated corticosterone

Jankowski

Ignatowska‐Jankowska

Glac

et al. 2010

International Immunopharmacology

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“…Faster progression of HIV infection and increased incidence of acquired immunodeficiency syndrome (AIDS) in addicts suggests that AMPH use results in a functional impairment of the immune systems, which selectively involves the peripheral blood lymphocyte subsets, in particular, the TCD4 + /TCD8 + lymphocyte ratio. The TCD4 + /TCD8 + lymphocyte ratio in blood is used in the diagnosis of HIV infections (Pahwa et al 2008 ), hepatitis C virus (Viso et al 2007 ) and autoimmune disorders (Pichler et al 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Prolonged Peripheral Immunosuppressive Responses as Consequences of Random Amphetamine Treatment, Amphetamine Withdrawal and Subsequent Amphetamine Challenges in Rats

Glac

Dunacka

Grembecka

et al. 2021

J Neuroimmune Pharmacol

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Drug-induced immunosuppression may underline increased hypothalamic–pituitary–adrenal axis response to stress observed following chronic psychostimulant treatment. However, the consequences of random amphetamine (AMPH) treatment, withdrawal and AMPH challenge after withdrawal on the peripheral immunity and systemic corticosterone response are unknown. In this study, the total blood and spleen leukocyte, lymphocyte, T, B, NK, TCD4+/TCD8+ cell numbers and ratio, pro-inflammatory interferon gamma (IFN-γ), and anti-inflammatory interleukin-4 (IL-4) production, and plasma corticosterone concentration in Wistar rats were investigated after: chronic, random AMPH/SAL treatment alone (20 injections in 60 days, 1 mg/kg b.w., i.p.), AMPH/SAL withdrawal (for 20 consecutive days after random AMPH/SAL exposure) or AMPH/SAL challenge after withdrawal (single injection after the AMPH/SAL withdrawal phase). The results showed blood and spleen leukopenia, lymphopenia, lower blood production of IFN-ɤ, and increased plasma corticosterone concentration after the AMPH treatment, which were more pronounced in the AMPH after withdrawal group. In contrast, an increased number of blood NK cells and production of IL-4 after chronic, random AMPH treatment alone, were found. Blood AMPH-induced leukopenia and lymphopenia were due to decreased total number of T, B lymphocytes and, at least in part, of granulocytes and monocytes. Moreover, decreases in the number of blood TCD4+ and TCD8+ lymphocytes both in the AMPH chronic alone and withdrawal phases, were found.The major findings of this study are that AMPH treatment after the long-term withdrawal from previous random AMPH exposure, accelerates the drug-induced immunosuppressive and systemic corticosterone responses, suggesting prolonged immunosuppressive effects and an increase in incidence of infectious diseases. Graphical Abstract Prolonged peripheral immunosuppressive responses as consequences of random amphetamine…The results indicate that the chronic and random AMPH exposure alone and the acute (single injection) challenge of the drug after the withdrawal phase induced long-term immunosuppressive effects, which were similar to those occurring during the stress response, and sensitized the peripheral immunosuppressive and corticosterone responses of the rat to the disinhibitory effects of this stressor.

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“…Since its discovery in 1989, hepatitis C virus (HCV) has been recognized as the leading cause of chronic liver disease in the world. Approximately 3% of the world population suffers from chronic hepatitis C (3,22) .…”

Section: Introductionmentioning

confidence: 99%

Analysis of Polymorphisms in the Interleukin 18 Gene Promotor (-137 G/C and -607 C/A) in Patients Infected With Hepatitis C Virus From the Brazilian Amazon

Santos

Almeida

Fecury

et al. 2015

Arq. Gastroenterol.

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Portal cd4+ and cd8+ t lymphocyte correlate to intensity of interface hepatitis in chronic hepatitis C

Cited by 8 publications

References 40 publications

Cocaine administration increases CD4/CD8 lymphocyte ratio in peripheral blood despite lymphopenia and elevated corticosterone

Cocaine administration increases CD4/CD8 lymphocyte ratio in peripheral blood despite lymphopenia and elevated corticosterone

Prolonged Peripheral Immunosuppressive Responses as Consequences of Random Amphetamine Treatment, Amphetamine Withdrawal and Subsequent Amphetamine Challenges in Rats

Analysis of Polymorphisms in the Interleukin 18 Gene Promotor (-137 G/C and -607 C/A) in Patients Infected With Hepatitis C Virus From the Brazilian Amazon

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