Combined effect of the essential oil from Chenopodium ambrosioides and antileishmanial drugs on promastigotes of Leishmania amazonensis

Monzote, Lianet; Montalvo, Ana Margarita; Scull, Ramón; Martínez, Migdalia Miranda; Abreu, Juan

doi:10.1590/s0036-46652007000400012

Cited by 36 publications

(23 citation statements)

References 22 publications

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“…Studies associating natural products with classical antileishmanials demonstrated synergism when Chenopodium ambrosioides essential oil was used in combination with pentamidine against L. amazonensis; synergism was not observed when this essential oil was used in combination with AMB (42). Recently, it was reported that the association of AMB and allicin, a natural product present in plants of the family Alliaceae, was synergistic for Leishmania infantum and L. donovani (43).…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Is Active against Leishmania amazonensis: In Vitro Effect of Its Association with Amphotericin B

Ferreira

Soares

Nascimento

et al. 2014

Antimicrob Agents Chemother

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Resveratrol is a polyphenol found in black grapes and red wine and has many biological activities. In this study, we evaluated the effect of resveratrol alone and in association with amphotericin B (AMB) against Leishmania amazonensis. Our results demonstrate that resveratrol possesses both antipromastigote and antiamastigote effects, with 50% inhibitory concentrations (IC 50 s) of 27 and 42 M, respectively. The association of resveratrol with AMB showed synergy for L. amazonensis amastigotes, as demonstrated by the mean sums of fractional inhibitory index concentration (mean ⌺FIC) of 0.483, although for promastigotes, this association was indifferent. Treatment with resveratrol increased the percentage of promastigotes in the sub-G 0 /G 1 phase of the cell cycle, reduced the mitochondrial potential, and showed an elevated choline peak and CH 2 -to-CH 3 ratio in the nuclear magnetic resonance (NMR) spectroscopy analysis; all these features indicate parasite death. Resveratrol also decreased the activity of the enzyme arginase in uninfected and infected macrophages with and without stimulation with interleukin-4 (IL-4), also implicating arginase inhibition in parasite death. The anti-Leishmania effect of resveratrol and its potential synergistic association with AMB indicate that these compounds should be subjected to further studies of drug association therapy in vivo.

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Section: Discussionmentioning

confidence: 99%

Resveratrol Is Active against Leishmania amazonensis: In Vitro Effect of Its Association with Amphotericin B

Ferreira

Soares

Nascimento

et al. 2014

Antimicrob Agents Chemother

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“…The combination of chemotherapy for treatment of leishmaniasis and other infectious diseases has been addressed in latter years 7,9,14,[21][22][23]26,30,32,34 . Recently, we showed that HBO is toxic for L. amazonensis promastigotes and can reduce macrophage susceptibility to infection and the size of footpad lesion in BALB/c mice 2,3 .…”

Section: Discussionmentioning

confidence: 99%

“…Various compounds have been tested, combined with glucantime, in order to improve chemotherapy 7,9,14,[21][22][23]26,28,30,34 , and the rationale behind combining drugs and therapies allows the reduction of treatment duration, resulting in fewer side effects and fewer delays in the development of resistance 8,34 . This report describes the effect of the combined therapy of HBO and glucantime against intracellular amastigotes in vitro and against infection in mouse model BALB/c.…”

Section: Introductionmentioning

confidence: 99%

Potential utility of hyperbaric oxygen therapy and propolis in enhancing the leishmanicidal activity of glucantime

Ayres

Fedele

Marcucci

et al. 2011

Rev. Inst. Med. trop. S. Paulo

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SUMMARYIn this study we investigated the efficacy of hyperbaric oxygen (HBO) therapy, alone or combined with the pentavalent antimonial glucantime on Leishmania amazonensis infection. In parallel, the effect of Brazilian red propolis gel (propain) alone or combined with glucantime on L. amazonensis infection was evaluated. The inhibition of the infection in macrophages treated with glucantime in combination with HBO exposition was greater than that of macrophages treated with glucantime alone or HBO alone. The susceptible mouse strain BALB/c infected in the shaved rump with L. amazonensis treated with glucantime and exposed to HBO showed: time points in the course of the disease in which lesions were smaller than those of mice treated with glucantime alone and revascularization of the skin in the lesion site; interferon-gamma (IFN-γ) levels were not elevated in lymph node cells from these animals. Propain alone was not efficient against lesions, although less exudative lesions were observed in animals treated with propain alone or combined with glucantime. These results reveal the potential value of HBO and red propolis in combination with glucantime for treating cutaneous leishmaniasis and encourage further studies on the effect of more aggressive HBO, propolis and glucantime therapies on different mouse models of leishmaniasis.

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“…[12][13][14][15][16][17][18][19][20][21][22][23][24][25] Rosa et al [26] and Ueda-Nakamura et al [27] reported the effects of the essential oils from Croton cajucara and Ocimum gratissimum on L. amazonensis. Monzote et al [28][29][30][31] revealed the activity of Chenopodium ambrosioides against Leishmania amazonensis and L. donovani. The effects of essential oils from Cymbopogon citratus (DC) Stapf., Lippia sidoides Cham.…”

Section: Introductionmentioning

confidence: 99%

Activity of essential oils on the growth of Leishmania infantum promastigotes

Machado

Santoro

Sousa

et al. 2010

Flavour & Fragrance J

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In order to contribute to the search for new therapeutic agents for leishmaniasis, we report the effect of several essential oils on the growth of Leishmania infantum promastigotes. Eight of the tested essential oils revealed activity below 150 mg/ml, the most active being Cymbopogon citratus, Juniperus oxycedrus berries and Thymus capitelatus oils, with 50% effective concentration values in the range 16-51 mg/ml. The results support the concept that several essential oils or some of their constituents can become useful in the research of new therapeutic agents for leishmaniasis and in the clinical management of this parasitic disease.

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Combined effect of the essential oil from Chenopodium ambrosioides and antileishmanial drugs on promastigotes of Leishmania amazonensis

Cited by 36 publications

References 22 publications

Resveratrol Is Active against Leishmania amazonensis: In Vitro Effect of Its Association with Amphotericin B

Resveratrol Is Active against Leishmania amazonensis: In Vitro Effect of Its Association with Amphotericin B

Potential utility of hyperbaric oxygen therapy and propolis in enhancing the leishmanicidal activity of glucantime

Activity of essential oils on the growth of Leishmania infantum promastigotes

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