2007
DOI: 10.1590/s0036-46652007000400008
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Abstract: SUMMARYAn open trial to evaluate the azithromycin efficacy in cutaneous leishmaniasis patients was carried out in Manaus (AM), where Leishmania (Viannia) guyanensis is the main etiologic agent. Forty-one patients with skin lesions of less than 12 weeks duration, without specific treatment for the last three months and a positive imprint to Leishmania sp. were included. From these, 31 (75.6%) were male with median age of 30.2. All of them received a daily-single oral dose of 500 mg of azithromycin for ten days.… Show more

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Cited by 11 publications
(7 citation statements)
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References 27 publications
(21 reference statements)
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“…However, its use is limited to patients with treatment failure or contraindications for all other options, such as young children, pregnant women, or patients with a severe underlying disease [157,158].…”
Section: Azithromycinmentioning
confidence: 99%
“…However, its use is limited to patients with treatment failure or contraindications for all other options, such as young children, pregnant women, or patients with a severe underlying disease [157,158].…”
Section: Azithromycinmentioning
confidence: 99%
“…Until now, few studies have tested azithromycin as an alternative treatment for CL [10][11][12]14,15 . Only one study was a randomized clinical trial that compared oral azithromycin and meglumine antimoniate for the treatment of CL in Americas, which included 23 patients in each study group.…”
Section: Discussionmentioning
confidence: 99%
“…Prata et al 13 showed a cure rate of 85% in an open non-controlled trial with 20 patients 13 . Four studies in Brazil showed low effi cacy of azithromycin when compared with meglumine antimoniate 10,14,15 . Two others studies evaluated azithromycin against Old World leishmaniasis, both with poor responses 11,12 .…”
Section: Methodsmentioning
confidence: 99%
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“…Um dos pacientes que não teve resposta com a paromomicina foi tratado com azitromicina que tem sido relatada com algum efeito sobre a leishmaniose 25 . Os resultados encorajam a realização de novos ensaios controlados em uma população de doentes menos selecionada que permita estimar a eficácia da droga.…”
Section: Discussionunclassified