Pulmonary tuberculosis: relationship between sputum bacilloscopy and radiological lesions

Gomes, Mauro; Saad, Roberto; Stirbulov, Roberto

doi:10.1590/s0036-46652003000500007

Cited by 27 publications

(24 citation statements)

References 21 publications

(46 reference statements)

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“…Chest X-rays with an anteroposterior view were obtained and temporally related sputum samples were collected for bacilloscopic study or culture [33,34]. Imaging methods were also used for diagnosis of the clinical form of TB [33,34].…”

Section: Methodsmentioning

confidence: 99%

Clinical forms and outcome of tuberculosis in HIV-infected patients in a tertiary hospital in São Paulo - Brazil

Klautau¹,

Kuschnaroff²

2005

Braz J Infect Dis

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Section: Methodsmentioning

confidence: 99%

Clinical forms and outcome of tuberculosis in HIV-infected patients in a tertiary hospital in São Paulo - Brazil

Klautau¹,

Kuschnaroff²

2005

Braz J Infect Dis

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“…The presence of cavitary disease on chest radiograph at the time of diagnosis also is a strong predictor of relapse after treatment (9)(10)(11)(12)(13)(14). The proportion of adults with newly diagnosed TB who have cavitary disease ranges from 40 to 87% (15)(16)(17). Patients …”

mentioning

confidence: 99%

Shortening Treatment in Adults with Noncavitary Tuberculosis and 2-Month Culture Conversion

Johnson¹,

Hadad²,

Dietze³

et al. 2009

Am J Respir Crit Care Med

129

108

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Rationale: Cavitary disease and delayed culture conversion have been associated with relapse. Combining patient characteristics and measures of bacteriologic response might allow treatment shortening with current drugs in some patients. Objectives: To assess whether treatment could be shortened from 6 to 4 months in patients with noncavitary tuberculosis whose sputum cultures converted to negative after 2 months. Methods: This study was a randomized, open-label equivalence trial. HIV-uninfected adults with noncavitary tuberculosis were treated daily with isoniazid, rifampin, pyrazinamide, and ethambutol for 2 months, followed by 2 months of isoniazid and rifampin. After 4 months, patients with drug-susceptible TB whose sputum cultures on solid media were negative after 8 weeks of treatment were randomly assigned to continue treatment for 2 more months or to stop treatment. Patients were followed for relapse for 30 months after beginning treatment. Measurements and Main Results: Enrollment was stopped by the safety monitoring committee after 394 patients were enrolled due to apparent increased risk for relapse in the 4-month arm. A total of 370 patients were eligible for per protocol analysis. Thirteen patients in the 4-month arm relapsed, compared with three subjects in the 6-month arm (7.0 vs. 1.6%; risk difference, 0.054; 95% confidence interval with Hauck-Anderson correction, 0.01-0.10). Conclusion: Shortening treatment from 6 to 4 months in adults with noncavitary disease and culture conversion after 2 months using current drugs resulted in a greater relapse rate. The combination of noncavitary disease and 2-month culture conversion was insufficient to identify patients with decreased risk for relapse.

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“…The proportion of adults with pulmonary tuberculosis (TB) who have cavitary disease at the time of diagnosis ranges from 40 to 87% (1,9,17). Several studies using qualitative smears and cultures have shown that patients with cavitary pulmonary TB have higher bacterial loads in their sputum (3,9,10,12,15).…”

mentioning

confidence: 99%

“…Several studies using qualitative smears and cultures have shown that patients with cavitary pulmonary TB have higher bacterial loads in their sputum (3,9,10,12,15). In 1965, Canetti and Grosset compared bacillary load in lung sections from resected lung tissue in patients with pulmonary TB.…”

mentioning

confidence: 99%

Cavitary Disease and Quantitative Sputum Bacillary Load in Cases of Pulmonary Tuberculosis

et al. 2007

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Pulmonary tuberculosis: relationship between sputum bacilloscopy and radiological lesions

Abstract: Parenchymal-infiltrate lesions are the most frequent radiological manifestation of pulmonary tuberculosis, and they are generally associated with cavities. There is a relationship between the presence of acid fast bacilli in sputum and pulmonary cavity lesions.

Cited by 27 publications

References 21 publications

Clinical forms and outcome of tuberculosis in HIV-infected patients in a tertiary hospital in São Paulo - Brazil

Clinical forms and outcome of tuberculosis in HIV-infected patients in a tertiary hospital in São Paulo - Brazil

Shortening Treatment in Adults with Noncavitary Tuberculosis and 2-Month Culture Conversion

Cavitary Disease and Quantitative Sputum Bacillary Load in Cases of Pulmonary Tuberculosis

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