Morbidity and survival in advanced AIDS in Rio de Janeiro, Brazil

Gadelha, Angela Jourdan; Accácio, Náurea; Costa, Regina Lana Braga; Galhardo, Maria Clara Gutierrez; Cotrim, Maria Regina; Souza, Rogério Valls de; Morgado, Mariza G.; Marzochi, Keyla Belízia Feldman; Lourenço, Maria Cristina da Silva; Rolla, Valeria

doi:10.1590/s0036-46652002000400001

Cited by 23 publications

(27 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our study population displayed good adherence to treatment (88.5%), indicating increased survival and a reduced frequency in opportunistic diseases, including intestinal parasites. Several factors, such as service improvement and early diagnosis, in addition to HAART introduction, are involved in this scenario (44)(45)(46)(47). Some studies have linked nutritional status to intestinal parasitic infections (14,15,48).…”

Section: Discussionmentioning

confidence: 99%

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Amâncio¹,

Pascotto²,

Souza³

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

View full text Add to dashboard Cite

This study applied a socioeconomic questionnaire designed to evaluate the frequency of intestinal parasites and characterize epidemiological, nutritional, and immunological variables in 105 HIV/AIDS patients -with and without parasitic infections, attending the Day Hospital in Botucatu, UNESP, from 2007 to 2008. Body mass index was calculated and the following tests performed: parasitological stool examinations; eosinophil, IgE, CD4 + T and CD8 + T lymphocyte cell counts; albumin test; viral load measure; and TNF-α, IFN-γ, IL-2, IL-5 and IL-10 cytokine levels. Results were positive for parasitic intestinal infections in 12.4% of individuals. Most patients had good socioeconomic conditions with basic sanitation, urban dwellings, treated water supply and sewage, good nutritional and immunological status and were undergoing HAART. Parasites were found at the following frequencies: Entamoeba -five patients (38.5%), Giardia lamblia -four (30.7%), Blastocystis hominis -three (23.0%), Endolimax nana -two (15.4%), and Ascaris lumbricoides -one (7.7%). There were no significant differences between the two groups for eosinophils, albumin, IgE, CD4 + T and CD8 + T lymphocytes, INF-γ, IL-2, or IL-10. Most patients also showed undetectable viral load levels. Significant differences were found for TNF-α and IL-5. These results show the importance of new studies on immunodeficient individuals to increase understanding of such variables.

show abstract

Section: Discussionmentioning

confidence: 99%

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Amâncio¹,

Pascotto²,

Souza³

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

View full text Add to dashboard Cite

show abstract

“…3,23 Vários autores atribuem o aumento dessa sobrevida ao uso da terapia anti-retroviral, especialmente dos inibidores de protease. [5][6][7][8]11,12,33 Este estudo contou tão-somente com informações da vigilância epidemiológica e não lhe foi possível estimar o impacto do uso da medicação, tanto o acesso a ela como a adesão ao tratamento, na sobrevida do paciente.…”

Section: Metodologiaunclassified

“…Essa maior sobrevida também é associada a faixas etárias mais jovens, porém a importância do sexo nessa associação permanece controversa. [5][6][7][8] O início da terapia anti-retroviral a partir de 1996 melhorou substancialmente o tempo de sobrevida e o quadro clínico-laboratorial, além de reduzir internações das pessoas vivendo com HIV/aids. 3,[9][10][11][12] O acesso aos serviços de saúde -principalmente os de assistên-cia especializada -e a medicamentos, e dificuldades relativas à adesão ao tratamento ainda causam impacto negativo em sua sobrevida.…”

Section: Introductionunclassified

Fatores associados à sobrevida de pessoas vivendo com aids no Município de Blumenau, Estado de Santa Catarina, Brasil, 1997-2004

Helena

Mafra

Simes

2009

Epidemiol. Serv. Saúde

View full text Add to dashboard Cite

“…In patients diagnosed in 1995 and 1996, the mean survival increased to 18 and 58 months, respectively 4 . More recently, in 2002, a mean survival time of 7 years was reported 5 .…”

Section: Introductionmentioning

confidence: 99%

“…Several factors are implicated in the prolonged survival of patients with AIDS, including improved services, early diagnosis, the introduction of antiretroviral (ARV) therapy, laboratorial follow-up, and the values of markers of disease progression such as viral load and CD4 T lymphocytes 5 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of laboratory markers of progression of HIV disease to death

Viana

Nascimento

Ferreira

et al. 2011

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Introduction:One of the important current problems in HIV/AIDS infection is the establishment of epidemiological and laboratorial prognostic parameters during patient followup. This study aimed at analyzing the evolution of laboratory tests: CD4 lymphocyte count, viral load, hemoglobin (Hb), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and the epidemiological variables sex and age as prognostic factors for survival in progression to death among AIDS patients. Methods: A retrospective study was conducted using analysis of medical records, and prospective 24-month follow-up of patients with HIV/ AIDS attended at the President Vargas Hospital Outpatient Clinic, a reference center in HIV/ AIDS attendance in the State of Maranhão, Brazil. The study analyzed patients aged 10 to 60 years old, who manifested AIDS and who were not using antiretroviral therapy or had used it for less than 5 years. The Chi-square test was used for statistical analysis. Results: The sample included 100 patients -57 were current outpatients, and 43 had died. The variables viral load (p=0.726), ALT (p=0.314), sex (p=0.687), and age (p=0.742) were analyzed, and no evidence of association between them and worst prognosis was observed. Conclusions: A significant relation was verified between low Hb levels (p=0.000) and CD4 (p=0.000) and shorter survival.

show abstract

Morbidity and survival in advanced AIDS in Rio de Janeiro, Brazil

Cited by 23 publications

References 15 publications

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Fatores associados à sobrevida de pessoas vivendo com aids no Município de Blumenau, Estado de Santa Catarina, Brasil, 1997-2004

Evaluation of laboratory markers of progression of HIV disease to death

Contact Info

Product

Resources

About