VALIDATION OF 14C-UREA BREATH TEST FOR DIAGNOSIS OF Helicobacter pylori

Mattar, Rejane; Silva, Fernando Marcuz; Alexandrino, Ana Maria; Laudanna, Antônio Atílio

doi:10.1590/s0036-46651999000100002

Cited by 15 publications

(18 citation statements)

References 9 publications

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“…Even though the radiation exposure from 14 C-urea breath test is less than 1% of that received from an upper gastrointestinal series 22 , the cost of a β counter is low, and the test has 100% specificity and sensitivity 23 , the long half life (5.730 years) 3 of 14 C restricts its use due to the environmental protection policy. That means 13 C-urea breath test and the stool antigen test are the only choices of non-invasive methods for H. pylori-infection eradication control.…”

Section: Discussionmentioning

confidence: 99%

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Validation of a rapid stool antigen test for diagnosis of Helicobacter pylori infection

Silva

Villares

Monteiro

et al. 2010

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe aim of this study was to validate the rapid lateral flow Helicobacter pylori stool antigen test (One step H. pylori antigen test, ACON laboratories, San Diego, USA; Prime diagnostics, São Paulo), using 13 C-Urea Breath Test as the gold standard for H. pylori infection diagnosis. A total of 98 consecutive patients, asymptomatic or dyspeptic, entered the study. Sixty-nine were women, with a mean age of 45.76 ± 14.59 years (14 to 79 years). In the H. pylori-positive group, the rapid stool antigen test detected H. pylori antigen in 44 of the 50 positive patients (sensitivity 88%; 95% CI: 75.7-95.5%), and six false-negative; and in the H. pylori-negative group 42 presented negative results (specificity 87.5%; 95% CI: 74.7-95.3%), and six false-positive, showing a substantial agreement (Kappa Index = 0.75; p < 0.0001; 95% CI: 0.6-0.9). Forty four of fifty patients that had positive stool antigen were H. pylori-positive, the PPV of the stool antigen test was 88% (95% CI: 75.7-95.5%), and 42 patients with negative stool antigen test were H. pylori-negative, the NPV of the stool antigen test was 87.5% (95% CI: 74.7-95.3%). We conclude that the lateral flow stool antigen test can be used as an alternative to breath test for H. pylori infection diagnosis especially in developing countries.

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Section: Discussionmentioning

confidence: 99%

“…Non-invasive methods, 14 C-urea breath test ( 14 C-UBT) 22,23 and 13 C urea breath test ( 13 C-UBT), are considered gold standard 19 . Recently, a noninvasive diagnostic test based on the detection of H. pylori stool antigen has been developed.…”

Section: Introductionmentioning

confidence: 99%

Validation of a rapid stool antigen test for diagnosis of Helicobacter pylori infection

Silva

Villares

Monteiro

et al. 2010

Rev. Inst. Med. trop. S. Paulo

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“…14 C‐urea breath test was performed for H. pylori recurrence diagnosis according to technique previously described [18]. Patients with positive breath test were submitted to an upper digestive tract endoscopy for ulcer healing evaluation and H. pylori identification.…”

Section: Methodsmentioning

confidence: 99%

Helicobacter pylori Recurrence in Patients with Duodenal Ulcer: Clinical, Endoscopic, Histologic, and Genotypic Aspects. A 10‐Year Brazilian Series

et al. 2006

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“…Helicobacter pylori infection is highly prevalent worldwide; its incidence rate varies in accordance with the geographical region studied and the age and socioeconomic conditions of infected individuals (21,33,40) . Around 50% of the population worldwide is estimated to be infected (6) ; however, only a small percentage of colonized individuals will develop a pathology related to the infection; for example, only 10%-20% will develop a gastric and/or duodenal ulcer (15) .…”

Section: Introductionmentioning

confidence: 99%

Neither genotype nor the gastric colonization site of Helicobacter pylori are predictive factors for the development of erosive esophagitis in patients with peptic ulcer disease, 1 year after eradication

Batista

Silva

Eisig

et al. 2009

Arq. Gastroenterol.

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-Context -WhetherHelicobacter pylori infection is a protective or predisposing factor for the development of gastroesophageal reflux disease remains controversial. The most virulent strains, such as those expressing the cytotoxin-associated gene A (CagA), and the site of gastric colonization have been correlated with the prevention or development of esophagitis. Aim -To determine the incidence of erosive esophagitis following eradication of H. pylori in patients with peptic ulcer disease and to evaluate the association of erosive esophagitis with virulent strains of H. pylori and the site of gastric colonization. Methods -Triple therapy with lansoprazole, amoxicillin and clarithromycin was administered to 159 patients with peptic ulcer disease. Endoscopy, histopathology, urease and carbon-14 urea breath tests were performed prior to treatment, at 3 months and 1 year following treatment. Genotyping of H. pylori strains using polymerase chain reaction was performed separately on samples from the corpus and antrum. Results -One year after treatment, 148 successfully treated patients were reevaluated. Twenty-eight patients (19%) had erosive esophagitis, classified as Los Angeles grade A in 24 and B in 4. The samples taken from the corpus were CagA-positive in 18 patients (64%), while the samples taken from the antrum were CagA-positive in 21 patients (75%). Conclusions -The incidence of erosive esophagitis in peptic ulcer patients who had their H. pylori eradicated was 19%. No correlation was found between the gastric site colonized by H. pylori or strains expressing CagA and the prevention or development of erosive esophagitis in patients with peptic ulcer disease, 1 year after infection eradication. HEADINGS -Helicobacter pylori. Peptic ulcer. Esophagitis.

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VALIDATION OF 14C-UREA BREATH TEST FOR DIAGNOSIS OF Helicobacter pylori

Cited by 15 publications

References 9 publications

Validation of a rapid stool antigen test for diagnosis of Helicobacter pylori infection

Validation of a rapid stool antigen test for diagnosis of Helicobacter pylori infection

Helicobacter pylori Recurrence in Patients with Duodenal Ulcer: Clinical, Endoscopic, Histologic, and Genotypic Aspects. A 10‐Year Brazilian Series

Neither genotype nor the gastric colonization site of Helicobacter pylori are predictive factors for the development of erosive esophagitis in patients with peptic ulcer disease, 1 year after eradication

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