Detection of HTLV-I Antibodies and Dna in Blood Sample of a Patient With Myelopathy in Nigeria

Olaleye, O.D.; Ogunniyi, Abiodun D.; Sheng, Zhi; Li, Zhiliang; Rasheed, Suraiya

doi:10.1590/s0036-46651998000100011

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…Common causes of diseases of the peripheral nerves such as diabetes mellitus, chronic renal disease, and leprosy are easily excluded by history, clinical examination, and urinalysis. Viral syndromes such as HTLV-1, HTLV-2, and HIV,28 which also come into the differential diagnosis of spinal cord and peripheral nerve diseases, have not been shown to be prevalent in Nigeria 29. Vitamin B 12 deficiency was not demonstrated in patients with TAN in previous studies in Nigeria,30 31 and the prominence of peripheral signs and the absence of motor signs and mental changes distinguishes TAN from vitamin B 12 myelopathy.…”

Section: Discussionmentioning

confidence: 89%

Persistence of tropical ataxic neuropathy in a Nigerian community

Oluwole

Onabolu²,

Link³

et al. 2000

Journal of Neurology, Neurosurgery &Amp; Psychiatry

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Objectives-The term tropical ataxic neuropathy (TAN) is currently used to describe several neurological syndromes attributed to toxiconutritional causes. However, TAN was initially proposed to describe a specific neurological syndrome seen predominantly among the Ijebu speaking Yorubas in south western Nigeria. In this study, the prevalence of TAN was determined in Ososa, a semiurban community in south western Nigeria described as endemic for TAN in 1969, and its neurological features were compared with Strachan's syndrome, prisoners of war neuropathy, the epidemic neuropathy in Cuba, and konzo. Methods-A census of Ososa was followed by door to door screening of all subjects aged 10 years and above with a newly designed screening instrument. Subjects who screened positive had a neurological examination, and the diagnosis of TAN was made if any two or more of bilateral optic atrophy, bilateral neurosensory deafness, sensory gait ataxia, or distal symmetric sensory polyneuropathy were present. Results-A total of 4583 inhabitants were registered in the census. Of these, 3428 subjects aged 10 years and above were screened. The diagnosis of TAN was made in 206 of 323 subjects who screened positive for TAN. The prevalence of TAN was 6.0%, 3.9% in males and 7.7% in females. The highest age specific prevalence was 24% in the 60-69 years age group in women. Conclusion-The occurrence of TAN in Ososa continues at a higher prevalence than was reported 30 years ago. Its neurological features and natural history do not resemble those described for Strachan syndrome, epidemic neuropathy in Cuba, or konzo. The increasing consumption of cassava foods linked to its causation makes TAN of public health importance in Nigeria, the most populous African country.

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Section: Discussionmentioning

confidence: 89%

Persistence of tropical ataxic neuropathy in a Nigerian community

Oluwole

Onabolu²,

Link³

et al. 2000

Journal of Neurology, Neurosurgery &Amp; Psychiatry

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“…This is consistent with epediomological studies that show the prevalence of HTLV to vary along sex and reported a higher infection rate in African men or men of African descent. 59,61,62) This could suggest an etiological factor such as perinatal infectivity as against the transfusion transmission route. It is imperative to state here that excessive consumption of cassava containing cyanogenic glycosides is a major etiological factor associated with myelopathy, especially tropical ataxic neuropathies in southern states of Nigeria with the highest consumption as compared to the northern regions where zero studies have been reported.…”

Section: A C C E P T E Dmentioning

confidence: 99%

Seroprevalence of maternal peripartum human T-cell lymphotropic virus type-1 infection: a systematic review and meta-analysis of the Nigerian literature

Usman¹,

Musa²,

Shuaib³

et al. 2023

Clin Exp Pediatr

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The peripartum period is both a highly vulnerable stage and a significant indicator of a population's health status. Interest is increasing in Human T-cell leukemia virus type-1 (HTLV-1) transmission due to its adverse health impacts. However, nationally representative data on HTLV-1 that are important for health planning are unavailable for this subpopulation.This study aimed to conduct a pooled estimate of HTLV-1 prevalence among pregnant women in Nigeria to quantify its clinical burden and public health implications. This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis 2020 statement. After a systematic review of the Nigerian literature, 12 studies (2821 pregnant or postnatal women) were included in the final evidence synthesis. The estimated HTLV-1 prevalence in Nigerian peripartum women following a positive screening test by enzyme-linked immunosorbent assay was 5.44% (95% confidence interval [CI], 3.16-9.20%). A subgroup analysis of the two major regions showed a slightly higher prevalence in the Western versus Southern region (5.55% [95% CI, 2.49-11.87%]; and 4.91% [95% CI, 2.11-11.02]; P = 0.84). However, a subgroup analysis by geopolitical zone revealed that Southwestern and Northwestern Nigeria had the highest prevalence (9.23% [95% CI, 4.35-18.55; I 2 , 93%] and 7.15% [95% CI, 1.54-27.54]; I 2 , 92%).Our decade-old subgroup analysis found inconsistencies in the HTLV-1 prevalence. Furthermore, our literature review revealed a prevalence of HTLV infection among patients with various clinical types of lymphomas/leukemias and myelopathy of 2-22%. These findings have important implications in defining the epidemiological patterns of HTLV-1 infection in Nigeria. They also suggest the presence of HTLV-endemic clusters near lowendemic areas, even within the same geopolitical zones.

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Global HTLV-1/2 Burden and Associated Diseases

Williams¹

2018

Cancer and AIDS

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Detection of HTLV-I Antibodies and Dna in Blood Sample of a Patient With Myelopathy in Nigeria

Cited by 3 publications

References 7 publications

Persistence of tropical ataxic neuropathy in a Nigerian community

Persistence of tropical ataxic neuropathy in a Nigerian community

Seroprevalence of maternal peripartum human T-cell lymphotropic virus type-1 infection: a systematic review and meta-analysis of the Nigerian literature

Global HTLV-1/2 Burden and Associated Diseases

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