Genomic characterization of adenovirus serotype 7 isolated in Brazil from acute respiratory disease patients during the period from 1980 to 1991

Moraes, Marcia Terezinha Baroni de; Leite, Joana Pereira; Siqueira, Marilda M.; Portes, Silvana Augusta Rodrigues; Krawczuk, M.M.; Nascimento, Jussara Pereira do

doi:10.1590/s0036-46651997000400001

Cited by 11 publications

(12 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Likewise, RSV was more frequently found in association with ARI in children older than 24 months (p=0.029) ( of the samples confirms the importance of this agent as frequent cause of ARI in children, particularly those older than 24 months 65.82%, (p=0.029), test significance. Although most studies conducted in temperate climates show RSV to be a frequent cause of ARI in children younger than 5, predominantly in infants, (Moraes et al 1997, Patwari et al 1996, Robertson et al 2004), the present study has revealed somewhat surprisingly that in this region of Brazil RSV was predominantly detected in children between 2 and 5 years of age.…”

Section: Duringcontrasting

confidence: 52%

RSV Associated Disease in Hospitalized Children in Southeast Brazil: Higher Frequency in Older Children Than in Infants

Simas¹,

Gardinassi²,

Bittar³

et al. 2009

VR&R

View full text Add to dashboard Cite

Respiratory tract infection can lead to diseases such as pneumonia, bronchospasm, bronchiolitis and pleural effusion, and consequently to hospitalization. The aim of this study was to investigate the presence of viruses in hospitalized children with respiratory tract infection and to assess the correlation between lower respiratory tract infection (LRTI) and the viruses studied. We screened children from 0 to 6 years of age (1.4%) FLUB, in 3 (1.1%) FLUA and 1 (0.4%) PIV2. Furthermore, there was a significant correlation between viral infection and bronchiolitis (43/44 cases: 97.8%; p≤0.001) and RSV infection and bronchiolitis (30/44 cases: 68.2%; p≤0.001). Finally, this study has confirmed that not only is RSV the most important virus in association with bronchilitis in infants, but also can be frequently detected in children between 2 and 5 years of age hospitalized for ARI in this region. In addition, HRV was frequently detected in association with ARI requiring hospitalization.

show abstract

Section: Duringcontrasting

confidence: 52%

RSV Associated Disease in Hospitalized Children in Southeast Brazil: Higher Frequency in Older Children Than in Infants

Simas¹,

Gardinassi²,

Bittar³

et al. 2009

VR&R

View full text Add to dashboard Cite

show abstract

“…Previous analysis of Ad7 in Brazil had identified only the genome types Ad7b and Ad7e (Wadell et al 1985, Moraes et al 1997, Kajon et al 1999. The analysis of 40 strains of Ad7 identified in cases of ARI in patients living in Southern and Southeastern regions of Brazil showed that in a period of 12 years (1980)(1981)(1982)(1983)(1984)(1985)(1986)(1987)(1988)(1989)(1990)(1991) only the genome types Ad7b and Ad7e were identified (Moraes et al 1997). Similar result was observed among 14 strains of Ad7 isolated from respiratory specimens from patients with ARI Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Several reports of the genomic characterization of Brazilian Ad isolates from patients with respiratory, ocular and gastrointestinal infections have been published since 1988, but none of them included any Ad isolates of patients living in Northeast Brazil (Wadell et al 1985, Gomes et al 1988, Moraes et al 1997, Kajon et al 1999, de Albuquerque et al 2003, Moura et al 2007). These studies have shown an important genetic variability for members of subgenus C. Among members of subgenus B, serotype 3 has been represented by genotypes 3p1 and 3a variant described previously (Kajon et al 1999, Moura et al 2007.…”

mentioning

confidence: 99%

Antigenic and genomic characterization of adenovirus associated to respiratory infections in children living in Northeast Brazil

Moura¹,

Mesquita

Portes

et al. 2007

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

“…Information on the impact of adenovirus infections on the civilian adult population are rare as well, specially because the majority of epidemiologic studies that have been done in the country to evaluate the frequency of such infections were primarily targeted to the infantile population. In those studies the serotypes most common described were 1, 2, 3, 5 and 7 (TAKIMOTO et al, 1969;SUTMOLLER et al, 1983;NASCIMENTO et al, 1991;MORAES et al, 1997;KAJON et al, 1999).In this study, pharyngeal swabs were obtained from adults subjects: military recruits (221 specimens) from an army headquarter in Rio de Janeiro city, collected from April to November 2000, and civilian personnel (181 specimens), collected between March 2000 and November 2002, also in Rio de Janeiro city. The samples were collected from subjects with or without clinical symptoms.…”

mentioning

confidence: 98%

Adenoviruses isolated from civilian and military personnel in the city of Rio de Janeiro, Brazil

Albuquerque

Silva

Soares

et al. 2003

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

SUMMARYAdenovirus are important pathogen primarily associated to respiratory infections of children and military personnel, even though it is also associated to cases of conjunctivitis and keratoconjunctivitis. We analyzed respiratory secretion collected from subjects with and without respiratory infection symptoms, being 181 civilians and 221 military subjects. The samples were inoculated in HEp-2 and/or A549 tissue cultures for viral isolation. Samples presenting cytopathogenic effect (CPE) in any tissue culture were tested by a polymerase chain reaction (PCR) assay to confirm adenovirus isolation. The isolates confirmed as adenovirus were further analyzed by restriction endonuclease assay for determination of viral species. Three isolates were identified as specie A (two from civilian and one from military), one isolate from military was identified as specie C, and one isolate from civilian was identified as specie D. For two isolates the specie could not be identified. KEYWORDS: Adenovirus; Respiratory infections; Epidemiology.Human adenovirus comprises 51 serotypes classified into the genera Mastadenovirus of the Adenoviridae family, and are divided in six species (formerly subgenera) designated from A to F (BENKÖ et al., 1999;DE JONG et al., 1999, HORWITZ, 2001). The adenoviruses were first isolated and characterized as viral agent by two groups who were searching for the etiologic agents of acute respiratory infections (ROWE et al., 1953;HILLEMAN & WERNER, 1954). Besides respiratory diseases, which includes acute respiratory disease of the military recruits, acute febrile pharyngitis, pharingoconjuctival fever, and pneumonia, the adenoviruses have been associated to a variety of clinical syndromes, such as epidemic keratoconjunctivitis, acute hemorrhagic cystitis, hepatitis and gastroenteritis (HORWITZ, 2001). Recently, the detection of adenovirus genome was described in cases of myocarditis (PAUSCHINGER et al., 1999), sudden infant death associated to myocarditis and pericartitis (SHIMIZU et al., 1995), toxic shock-like syndrome (PRICE et al., 2001), and unexplained deaths (PERKINS et al., 1996). Isolation of adenovirus from patients with central nervous system manifestations such of fatal acute flaccid paralysis (CARDOSA et al., 1999) and encephalitis with cerebral edema have also been described (CHATTERJEE et al., 2000).Epidemiologic studies initiated by the Commission of Acute Respiratory Disease of the U.S. Armed Forces confirmed that the adenoviruses were the cause of a large number of respiratory syndromes among military recruits (GINSBERG et al., 1955;DINGLE & LANGMUIR, 1968). Because of crowded living conditions, stressful working environment, and exposure to respiratory pathogens in diseaseendemic areas, military trainees and newly mobilized troops are at particularly high risk for respiratory disease epidemics (GRAY et al., 1994;GAYDOS & GAYDOS, 1995). During the 1950s and 1960s, up to 10% of recruits were infected with adenovirus, and these pathogens were responsible for approximately 90% of ...

show abstract

Genomic characterization of adenovirus serotype 7 isolated in Brazil from acute respiratory disease patients during the period from 1980 to 1991

Cited by 11 publications

References 22 publications

RSV Associated Disease in Hospitalized Children in Southeast Brazil: Higher Frequency in Older Children Than in Infants

RSV Associated Disease in Hospitalized Children in Southeast Brazil: Higher Frequency in Older Children Than in Infants

Antigenic and genomic characterization of adenovirus associated to respiratory infections in children living in Northeast Brazil

Adenoviruses isolated from civilian and military personnel in the city of Rio de Janeiro, Brazil

Contact Info

Product

Resources

About