Concomitant high prevalence of Hepatitis C virus antibodies and Hepatitis B virus markers in a small village fo the Amazon Region, Mato Grosso State, Brazil

Souto, Francisco José Dutra; Fontes, Cor Jésus Fernandes; Gaspar, Ana; Paraná, Raymundo; Lyra, Luiz Guilherme Costa

doi:10.1590/s0036-46651996000300010

Cited by 12 publications

(9 citation statements)

References 7 publications

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“…Previous studies showed prevalence ranging from 0% to 3.6% in the Brazilian Amazon (Souto et al 1996(Souto et al , 1998b. The present study, with a larger and randomly chosen sample, yields a more representative result, indicating that this region has an intermediate endemicity of HCV infection.…”

Section: Discussionsupporting

confidence: 53%

“…Few publications have addressed HCV seroprevalence in the Amazon region and these studies were mainly conducted among selected groups, showing HCV prevalence ranging from 1.4% among Amazonian Indian tribes (Soares et al 1994) to 3.6% among immigrants living in the region (Souto et al 1996). However, interpretation of these seroprevalence studies should take into account the increased sensitivity and specificity of the different diagnostic assays performed in recent years compared to the first generation tests (MacDonald et al 1996).…”

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confidence: 99%

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Hepatitis C virus prevalence among an immigrant community to the Southern Amazon, Brazil

Souto

Fontes

Martelli

et al. 1999

Mem. Inst. Oswaldo Cruz

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A community-based random survey was conducted in a southern Brazilian Amazonian county aiming to investigate hepatitis C virus (HCV) infection prevalence and the association of demographic variables and lifestyle behaviours. Seven hundred eighty individuals were serologically screened with a third generation enzyme-linked immunosorbent assay to detect anti-HCV antibodies between 1994/1995. Positive samples were retested for confirmation with a line immunoassay (LIA, Inno-LIA HCV Ab III). Most of these subjects were low income and came from southern Brazilian states (65.8). Two point four percent (IC 95% 1.2%-4.6%) of the subjects had LIA-confirmed anti-HCV antibodies reactivity. The age-specific prevalence of HCV antibodies slightly increased with age, with the highest prevalence after the age of 40 years. The results of multivariate analysis indicate a strong association between HCV antibodies and previous surgery and history of intravenous drug use. There were no apparent association with gender, hepatitis B virus markers, blood transfusion, and sexual activity. Mean time living in Amazon did not differ between confirmed and negative anti-HCV individuals. The present data point out an intermediate endemicity of HCV infection among this immigrant community to the Amazon region and that few HCV infected participants presented known risk factors.

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Section: Discussionsupporting

confidence: 53%

mentioning

confidence: 99%

Hepatitis C virus prevalence among an immigrant community to the Southern Amazon, Brazil

Souto

Fontes

Martelli

et al. 1999

Mem. Inst. Oswaldo Cruz

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“…In addition, the rejection rate of blood donor candidates due to anti-HBc seropositivity has been found to be abnormally high in the Amazon region when compared to other regions of the country [15]. This is further demonstrated by the previous observation that 36.9% of individuals presented HBV markers.…”

Section: Discussionmentioning

confidence: 77%

Seroprevalence of hepatitis B and C in the Western Brazilian Amazon region (Rio Branco, Acre): a pilot study carried out during a hepatitis B vaccination program

et al. 2004

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In 1999, on the occasion of the application of the first vaccine dose during the state vaccination campaign against hepatitis B virus (HBV), 390 individuals from the town of Rio Branco, Acre, aged two or more years were selected for the determination of the seroprevalence of HBV and HCV. HBV markers (HBsAg, anti-HBs, and anti-HBc IgG) were determined on this occasion and anti-HBs antibodies were also assessed 30 days after the third vaccine dose. At the time of vaccination, 39% of the individuals were still susceptible to HBV, while 61% presented serologic evidence of previous HBV contact or previous vaccination. The individuals with previous HBV contact were significantly older (p<0.001) than those without HBV markers. Of the 192 individuals who returned for reexamination, 30 days after the third dose, 158 (82.3%) had received three vaccine doses, and only 60 (31.2%) belonged to the group without HBV markers. In these individuals, the seroconversion rate after the third dose was 92% (55/60). In conclusion, we found considerable HBV in this population, indicating the need for pursuing the immunization programs. We also found high rates of vaccination coverage in the Western Brazilian Amazon region.

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“…Most of individuals were native from that region, which suggests that infection with both HBV and HDV occurred inside the Purus and Acre rivers communities. Previous studies showed anti-HCV prevalence rates ranging from 0% to 3.6% in the Brazilian Amazon (Souto et al 1996(Souto et al , 1999. This study gives the first data on the anti-HCV prevalence in the western Amazon, which presented a low endemicity of HCV infection (1.7%).…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of viral hepatitis in riverine communities from the Western Region of the Brazilian Amazon Basin

Paula

Arruda

Vitral

et al. 2001

Mem. Inst. Oswaldo Cruz

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Concomitant high prevalence of Hepatitis C virus antibodies and Hepatitis B virus markers in a small village fo the Amazon Region, Mato Grosso State, Brazil

Cited by 12 publications

References 7 publications

Hepatitis C virus prevalence among an immigrant community to the Southern Amazon, Brazil

Hepatitis C virus prevalence among an immigrant community to the Southern Amazon, Brazil

Seroprevalence of hepatitis B and C in the Western Brazilian Amazon region (Rio Branco, Acre): a pilot study carried out during a hepatitis B vaccination program

Seroprevalence of viral hepatitis in riverine communities from the Western Region of the Brazilian Amazon Basin

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