Granulomatous inflammation

Pulmonary immune responses induced in BALB/c mice by Paracoccidioides brasiliensis conidia

“…In our PCM murine model, the sequential histophatological studies have revealed the kinetics of the inflammatory response consisting of three stages: (i) a neutrophilic or monocyte-neutrophilic stage, in which PMN and histiocytes are present, witnessing the early inflammatory process; (ii) a mixed granulomatous stage, in which epithelioid granulomata run in parallel with the presence of PMN and (iii) a granulomatous and fibrous-fibroblastic stage, characterized by presence of abundant giant cells, histiocytes, macrophages and fibrous conjunctive tissue [27,28,31,32].…”

Histoarchitecture of schistosomal granuloma development and involution: morphogenetic and biomechanical approaches

“…Some of these definitions, as well as the classification and pathogenesis of granulomas, have been discussed in reviews by Adams (1976Adams ( , 1983, Warren (1976), Epstein (1977), Boros (1978), Williams and Williams (1983), Hirsh and Johnson (1984), De Britto and Franco (1994) and Mariano (1995). Most of them stress the etiology, or the main cellular component, or the participation or not of the immune system, or the differences in terms of the relative number of the new macrophages entering the granuloma (low and high turnover granulomas), or the participation or not of tissue injury.…”

Erratum: Paracoccidioidomycosis of the Mouth: an Emerging Deep Mycosis

“…The so-called hyperergic spectrum of the disease is characterized by a localized infection, with cellular immune response and well-organized epithelioid granulomas. The anergic type presents as a disseminated infection, decreased cellular immunity, and poorly organized granulomas rich in fungi (Brito and Franco, 1994;Soares et al, 2000).…”