Atividade quimioprofilática na esquistossomose mansoni de sabonetes contendo óleo essencial de frutos de Pterodon pubescens

Abstract

Foi estudada a ação quimioprofilática na esquistossomose experimental do óleo essencial do fruto de Pterodon pubescens Benth (Leguminosae), incorporado a diferentes formulações de sabonete. As formulações foram usadas topicamente nas caudas de camundongos que, imediatamente, 24,72 ou 168 horas após, foram expostos a cercárias de Schistosoma mansoni, pelo método de imersão da cauda. A proteção foi avaliada 45 dias após a exposição, quando os camundongos foram sacrificados e os vermes recolhidos por perfusão. Os resultados mostraram níveis de proteção variando de 0,0 a 100% conforme a formulação usada. Foi também desenvolvida uma metodologia que possibilitou a avaliação do sabonete protetor quando camundongos foram expostos à infecção natural em córregos infestados com caramujos na periferia de Belo Horizonte, MG. Resultados promissores foram obtidos, uma vez que houve proteção de 57,5 e 31,1% quando os animais foram ensaboados 24 e 48 horas antes. Estudos preliminares de avaliação de irritação e toxicidade foram favoráveis e mostraram que esta nova arma profilática poderá auxiliar no controle da esquistossomose.

Floral ontogeny in Dipterygeae (Fabaceae) reveals new insights into one of the earliest branching tribes in papilionoid legumes

“…is commonly known as ‘sucupira‐branca’. The oil extracted from its fruits has been traditionally used for arthritis (Coelho et al ., ), rheumatism (Correa, ) and schistosomiasis (Santos‐Filho et al ., ; Katz et al ., ), and as an anti‐inflammatory (Nunan et al ., ; Carvalho et al ., ), antinociceptive (Duarte et al ., ; Coelho et al ., ) and antiulcerogenic (Dutra et al ., ).…”

Oil Glands in Pterodon pubescens Benth. (Leguminosae-Papilionoideae): Distribution, Structure, and Secretion Mechanisms

“…Pterodon pubescens Benth., popularly known as sucupira-branca, is native to the Brazilian Cerrado (Lorenzi 1998) and is important in folk and conventional medicine in this country. The oil from sucupira-branca, obtained from samara fruits, is used to treat rheumatism (Correa 1984), arthritis (Coelho et al 2001), and schistosomiasis (Katz et al 1993) and shows anti-inflammatory (Nunan et al 1982) and analgesic (Duarte et al 1996) properties.…”

The efficacy of soap against schistosome cercariae: A systematic review

“…In addition, two kinds of experimental soap formulations, Schistopel and soaps containing essential oils, were tested. Schistopel is an experimental soap formulation with hexachlorophene as a bacteriostatic agent [38], while other experimental soaps incorporated essential oils extracted from local plants into soap formulations [36,39]. Similar to endod, some essential oils showed promising toxicity against the intermediate hosts of Schistosoma spp.…”

“…In previous studies, living mice or rats were used as the host and soap was applied on their tails before being exposed to cercariae. Cercariae infectivity and viability were the adverse endpoints assessed, as the number of cercariae that failed to penetrate was counted in some studies [36,39,46], and worms were recovered after exposure in all studies [35,36,38,39,46]. Three studies considered the influence of rinsing which could potentially wash off soap; the tails were rinsed with water between soap application and exposure to cercariae [36,38,46].…”