The prolonged use of niclosamide as a molluscicide for the control of Schistosoma mansoni

Coura-Filho, Pedro; Mendes, Nelymar Martinelli; Souza, Cecília Pereira de; Pereira, José Paulo

doi:10.1590/s0036-46651992000500009

Cited by 13 publications

(9 citation statements)

References 11 publications

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“…Mas, considerado o fato de que os focos de transmissão da esquistossomose no distrito ocorrem em córregos e rios pequenos, a maioria com forte vasão, o moluscicida seria levado pela correnteza e teria breve ação no controle da transmissão do S. mansoni. Devem ser considerados também os altos custos desses produtos, os danos provocados por freqüentes aplicações à biota aquática, além da questionável eficácia para reduzir de forma duradouera o número de molusco (Coura-Filho, et al, 1992).…”

Section: Análise Multivariadaunclassified

Determinantes ambientais e sociais da esquistossomose mansoni em Ravena, Minas Gerais, Brasil

et al. 1995

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This study identified the role of biological and social determinants in the transmission of schistosomiasis mansoni in Ravena, Minas Gerais, Brazil, in 1980. This data was used to characterize the clinical and epidemiological profiles of the endemic desease in the population, allowing for the determination of the efficacy of the potable water supply and the specific treatment of those infected with S. mansoni. The district contains three locations, Ravenopolis, Ravena and Lavapes, where the prevalence of the endemic disease was, 20.1%, 42.6% and 63.9%, respectively. The prevalence in the district was statistically higher in men. The age brackets that displayed differences by gender were 10-14 and 15-19 years. Severity of infection was statistically different among individuals within the 10-14 year bracket in ali three locations, and in the 15-19 year bracket among individuals from Ravenopolis and Ravena. The hepatointestinal form was associated with age, and individuals under 15 years of age presented risk of infection 8.85 times higher than adults. Multivariable analysis of the factors involved in transmission of the disease showed that Lavapes was independently associated with infection. In that area, poor sanitary conditions and the proximity of houses to streams infested with S. marsoni cercariae facilitated infection of neighborhood women while performing domestic activities, as well as men digging sand from the streams for construction. These results show the focal nature of transmission of the endemic requiring specific intervention for effective control of disease.

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Section: Análise Multivariadaunclassified

Determinantes ambientais e sociais da esquistossomose mansoni em Ravena, Minas Gerais, Brasil

et al. 1995

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“…In 1965, the dynamic modeling of MacDonald [7] prompted hopes there could be an ecological ‘breakpoint’ in Schistosoma spp. transmission if the local numbers of intermediate host snails could be reduced by 90% or more [8] – [10] . This local extinction was projected as a consequence of the obligate need for sexual reproduction by the parasite (dioecy) within the human host; if male and female worms could not combine within the same host, then transmission was effectively ended.…”

Section: Introductionmentioning

confidence: 99%

Population Biology of Schistosoma Mating, Aggregation, and Transmission Breakpoints: More Reliable Model Analysis for the End-Game in Communities at Risk

Gurarie

King

2014

PLoS ONE

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Mathematical modeling is widely used for predictive analysis of control options for infectious agents. Challenging problems arise for modeling host-parasite systems having complex life-cycles and transmission environments. Macroparasites, like Schistosoma, inhabit highly fragmented habitats that shape their reproductive success and distribution. Overdispersion and mating success are important factors to consider in modeling control options for such systems. Simpler models based on mean worm burden (MWB) formulations do not take these into account and overestimate transmission. Proposed MWB revisions have employed prescribed distributions and mating factor corrections to derive modified MWB models that have qualitatively different equilibria, including ‘breakpoints’ below which the parasite goes to extinction, suggesting the possibility of elimination via long-term mass-treatment control. Despite common use, no one has attempted to validate the scope and hypotheses underlying such MWB approaches. We conducted a systematic analysis of both the classical MWB and more recent “stratified worm burden” (SWB) modeling that accounts for mating and reproductive hurdles (Allee effect). Our analysis reveals some similarities, including breakpoints, between MWB and SWB, but also significant differences between the two types of model. We show the classic MWB has inherent inconsistencies, and propose SWB as a reliable alternative for projection of long-term control outcomes.

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“…Molluscicide 3. Molluscicide 3 is widely used for the control of freshwater mollusk intermediary hosts of infectious diseases, as well as pest species of cultured plants (Greer et al, 1996; Lima et al, 1996; Schnorbach, 1995; Engels et al, 1993; Coura Filho et al, 1992). Recommended concentrations for this toxicant are 0.85–4.3 mg/L.…”

Section: Discussionmentioning

confidence: 99%

Toxicity of chlorine and three nonoxidizing molluscicides to the pest mussel Limnoperna fortunei

Cataldo¹,

Boltovskoy²,

Pose³

2003

Journal AWWA

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The freshwater Asiatic mussel Limnoperna fortunei invaded the Paraná–Uruguay river system in Argentina around 1990. Since then, the pest mussel has spread extensively and is now a major nuisance for many industrial and domiciliary water supply systems. This research exposed L. fortunei adults to chlorine and three nonoxidizing commercial molluscicides for varying amounts of time at concentrations between 0.25 and 100 mg/L at 15, 20, and 25°C. At 25°C, chlorine was effective at all concentrations (1–100 mg/L) yielding 100% mortalities in 11–17 days. At 15 and 20°C, only concentrations ≥ 5 mg/L resulted in total kills after three to six weeks of exposure. The first molluscicide had little effect at 1 mg/L at all temperatures, but 2.5 mg/L of the molluscicide at 20 and 25°C attained 80–90% mortalities on the third day of postexposure. At 15°C, the second molluscicide failed to kill 100% of the mussels exposed at all concentrations tested. At 20°C, only doses > 10 mg/L eliminated all the mollusks, but at 25°C, all concentrations of the molluscicide down to 2.5 mg/L were 100% effective in one week or less. The third molluscicide proved to be the most toxic of the compounds tested, yielding > 50% mortalities at all temperatures at ≥ 1 mg/L. At higher temperatures, toxicity was substantially enhanced for all toxicants, especially chlorine.

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The prolonged use of niclosamide as a molluscicide for the control of Schistosoma mansoni

Cited by 13 publications

References 11 publications

Determinantes ambientais e sociais da esquistossomose mansoni em Ravena, Minas Gerais, Brasil

Determinantes ambientais e sociais da esquistossomose mansoni em Ravena, Minas Gerais, Brasil

Population Biology of Schistosoma Mating, Aggregation, and Transmission Breakpoints: More Reliable Model Analysis for the End-Game in Communities at Risk

Toxicity of chlorine and three nonoxidizing molluscicides to the pest mussel Limnoperna fortunei

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