1991
DOI: 10.1590/s0036-46651991000500001
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Abstract: Ten male Wistar rats, chronically infected with Colombian, São Felipe (12SF) and Y strains of Trypanosoma cruzi and ten non-infected control animals were submitted to the bradycardia responsiveness test, an assessment of heart parasympathetic function, after phenylephrine injection. Six chagasic animals showed heart parasympathetic dysfunction characterized by reduction in the index of bradycardia baroreflex responsiveness, as compared with the control group. Microscopic examination of the atrial heart ganglia… Show more

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Cited by 16 publications
(14 citation statements)
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“…The more probable pathogenetic mechanism is the primary direct chronic inflammatory or autoimmunological damage of ganglia and/or neuronal fibres (Lopes and Tafuri, 1983;Oliveira, 1985), as classically accepted on the basis of human and experimental animal studies (Junqueira et al, 1992;Marin-Neto, 1998). The possibility that in chagasics with the indeterminate form of disease, the autonomic disturbance is only due to neuroganglionic inflammation, is reinforced by the observation in the experimental rat model of T. cruzi infection developed in our laboratory that the exclusive presence of ganglionic and/or neuronal inflammation without neuroganglionic depopulation was sufficient to cause depression of the phenylephrine-induced baroreflex bradycardia (Chapadeiro et al, 1991). It is important to consider that this animal model imitates particularly the indeterminate form of human Chagas' disease, considering the discrete and focal nature of the underlying lesions (Junqueira et al, 1992).…”
Section: Discussionmentioning
confidence: 97%
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“…The more probable pathogenetic mechanism is the primary direct chronic inflammatory or autoimmunological damage of ganglia and/or neuronal fibres (Lopes and Tafuri, 1983;Oliveira, 1985), as classically accepted on the basis of human and experimental animal studies (Junqueira et al, 1992;Marin-Neto, 1998). The possibility that in chagasics with the indeterminate form of disease, the autonomic disturbance is only due to neuroganglionic inflammation, is reinforced by the observation in the experimental rat model of T. cruzi infection developed in our laboratory that the exclusive presence of ganglionic and/or neuronal inflammation without neuroganglionic depopulation was sufficient to cause depression of the phenylephrine-induced baroreflex bradycardia (Chapadeiro et al, 1991). It is important to consider that this animal model imitates particularly the indeterminate form of human Chagas' disease, considering the discrete and focal nature of the underlying lesions (Junqueira et al, 1992).…”
Section: Discussionmentioning
confidence: 97%
“…The human and experimental indeterminate forms present less conspicuous lesions of cardiac intrinsic innervation, which are usually represented by discrete to moderate focal or zonal chronic neuroganglionitis (Lopes and Tafuri, 1983;Andrade, 1984;Oliveira, 1985;Chapadeiro et al, 1991). Cardiac autonomic damage has also been observed in acute and chronic experimental Trypanosoma cruzi infection in mice (Tafuri, 1970;Souza et al, 1996), dogs (Andrade, 1984;Machado et al, 1998), rats (Chapadeiro et al, 1991;Junqueira et al, 1992), and hamsters (Chapadeiro et al, 1999) among other animal models.…”
Section: Introductionmentioning
confidence: 99%
“…Diffuse damage to the autonomic nervous system, principally of the parasympathetic branch affecting the heart and digestive tract, is a remarkable pathological feature commonly present in variable degrees and extents in the acute and all chronic forms of human Chagas disease 11,13,15,[17][18][19] and the corresponding forms of experimental Trypanosoma cruzi infection in different animal models [20][21][22][23][24] . This is a fact recognised soon after the description of the disease at the beginning of the past century.…”
Section: Cardiac Autonomic Nervous System In Chagas Diseasementioning
confidence: 99%
“…Many autonomic components, mainly related to functional modulation of the heart and digestive viscera, including central neural structures at different levels, peripheral extrinsic and intrinsic autonomic ganglia, afferent neurons from receptors, sympathetic and parasympathetic efferent neurons and the beta-adrenergic and muscarinic cholinergic neurotransmitter cellular receptors, may be injured exclusively or in combination, and this has been demonstrated both in human and experimental Chagas disease 11,13,15,18,[20][21][22][23][26][27][28][29] .…”
Section: Cardiac Autonomic Nervous System In Chagas Diseasementioning
confidence: 99%
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