Fifth disease in children living in Belém, Brazil

Miranda, Milton Edson; Linhares, Alexandre da Costa; Shirley, Jane A.

doi:10.1590/s0036-46651989000500011

Cited by 11 publications

(4 citation statements)

References 14 publications

(2 reference statements)

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“…The first description of EI with laboratory confirmation in Brazil was done during 1987 in Belém, PA 12 . Althought anti-B19 IgM detection was possible only for three patients, similar clinical findings were reported for ten other cases during a four -year period, 1984 to 1987 16 . Most of these cases occurred during the first half of the year (January to June).…”

Section: Discussionsupporting

confidence: 81%

Human parvovirus B19 infections among exanthematic diseases notified as measles

Cubel

Siqueira²,

Santos³

et al. 1997

Rev. Soc. Bras. Med. Trop.

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A total of 1397 sera collected from 1095 cases of exanthematic disease notified as measles in ES and RJ states during July 1992 to December 1994 were investigated. These sera were first tested for measles and rubella specific IgM. When they proved negative, they were tested for B19 specific IgM by an enzyme immunoassay. B19 infection was confirmed in 27 (2.5%) of these cases. Sera from 194 negative cases for measles and rubella IgM received from other Brazilian states were also investigated and B19 infection was confirmed for 11 of them. Sera from these 38 IgM positive cases for B19, were tested for anti-B19 IgG by an enzyme immunoassay and for B19 DNA by dot blot hybridization. Anti-B19 IgG antibodies were detected in most of the acute sera. B19 DNA was detected in the acute serum of one patient that had been splenectomized before. As the exanthem caused by human parvovirus infection may be clinically diagnosed as rubella, it could be important to diagnose B19 infection in Brazil since it is becoming prevalent as the cause of rash in countries where rubella is controlled by vaccination.
Um total de 1397 soros colhidos de 1095 casos de exantema notificados como sarampo, nos estados do ES e RJ, no período de julho de 1992 a dezembro de 1994, foram investigados. Estes soros foram inicialmente testados para sarampo e rubéola por detecção de IgM específica. Os casos negativos foram então testados para a presença de IgM específca anti-B19 por um ensaio imunoenzimático. A infecção pelo B19 foi confirmada em 27 (2,5%) destes casos. Soros de 194 casos negativos para sarampo e rubéola provenientes de outros estados brasileiros foram também investigados, e a infecção pelo B19 pode ser confirmada em 11 destes casos. Os soros dos 38 casos IgM positivos para B19 foram testados para a presença de IgG específica anti-B19 por um ensaio imunoenzimático, e para a presença do ADN viral por hibridização em "dots" (dot blot). IgG específica anti-B19 pode ser detectada na maioria dos soros de fase aguda, e o ADN viral foi detectado no soro de fase aguda de um paciente esplenectomizado. Como o exantema causado pela infecção pelo parvovírus humano pode ser clinicamente diagnosticado como rubéola, seria importante realizar o diagnóstico desta virose no Brasil, já que um aumento no número de casos de exantema por B19 tem sido relatado nos países onde a rubéola é controlada por vacinação

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Section: Discussionsupporting

confidence: 81%

Human parvovirus B19 infections among exanthematic diseases notified as measles

Cubel

Siqueira²,

Santos³

et al. 1997

Rev. Soc. Bras. Med. Trop.

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“…In our study, 92.4% of the cases were recorded during this season, similar to the report by Cubel et al (1997) for other regions of Brazil. However, different findings were reported in the Amazon region by Miranda et al (1989), who described higher incidence of the disease during the first half of the year, a season of heavy rainfall and high humidity in the North of our country.…”

Section: Discussioncontrasting

confidence: 72%

“…Although some studies (Freitas et al 1988, 1993, Miranda et al 1989, Nascimento et al 1990, Cubel et al 1992, Mielle et al 1995 have been published in recent years, including preliminary results of the first year of this study (Oliveira et al 1996), clinical and epidemiological aspects of parvovirus B19 are still not widely documented in Brazil. By systematically gathering data on acute rash diseases over the years we disclosed a seasonal pattern of the infection in a mid-sized urban area.…”

Section: Discussionmentioning

confidence: 81%

Clinical and epidemiological aspects of human parvovirus B19 infection in an urban area in Brazil (Niterói city area, State of Rio de Janeiro, Brazil)

Oliveira

Camacho

Pereira

et al. 2002

Mem. Inst. Oswaldo Cruz

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“…In the following years only scattered cases of human parvovirus B19 were seen which is consistent with the pattern of infection seen elsewhere. Although some small studies [24][25][26] have been published in recent years, the epidemiology of human parvovirus B19 is still not well documented in Brazil.…”

Section: Discussionmentioning

confidence: 99%

The aetiology of maculopapular rash diseases in Niterói, State of Rio de Janeiro, Brazil: implications for measles surveillance

et al. 2001

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A study investigating the causes of rash diseases using systematic laboratory testing was conducted in Niterói, Rio de Janeiro, between January 1994 to April 1998. Sera from 327 patients were tested for evidence of anti-rubella virus, measles virus, human parvovirus B19 and dengue fever virus specific immunoglobulin IgM and anti-human herpes virus type 6 (HHV-6) IgG antibodies. A laboratory confirmed diagnosis was achieved in 71.3% of the cases investigated: dengue fever (33.0%), rubella (20.2%), parvovirus B19 (9.2%), measles (6.7%) and HHV-6 (2.1%). No diagnosis was established for 94 cases (28.7%). An outbreak of measles was detected during 1997, with a peak in September and October. All of the diseases studied here presented with clinical features similar to measles and classical symptoms were found in all measles confirmed cases. The large overlap of combinations of signs and symptoms seen in this study highlights the difficulties of diagnosing a rash illness on clinical grounds alone.

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Fifth disease in children living in Belém, Brazil

Abstract: SUMMARYAcute ser a fro m tw o childre n sufferin g fro m a n illnes s wit h a n erythematou s rash were positive fo r B 1 9 virus specific IgM antibody , a s tested b y a capture radioim¬

Cited by 11 publications

References 14 publications

Human parvovirus B19 infections among exanthematic diseases notified as measles

Human parvovirus B19 infections among exanthematic diseases notified as measles

Clinical and epidemiological aspects of human parvovirus B19 infection in an urban area in Brazil (Niterói city area, State of Rio de Janeiro, Brazil)

The aetiology of maculopapular rash diseases in Niterói, State of Rio de Janeiro, Brazil: implications for measles surveillance

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