Hidatidosis humana: ecografía de campo para la determinación de grupos de alto riesgo en la evaluación de un programa de control

Larrieu, Edmundo; Frider, Bernardo; Andreani, Gustavo; Andreani, Georgina; Aquino, Alberto; Fuente, Reinaldo de la

doi:10.1590/s0036-46651989000400010

Cited by 7 publications

(5 citation statements)

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“…The general value of LI:LU among general, asymptomatic populations living in areas (of Argentina, China, Kenya, Libya, Tanzania, Tunisia and Uruguay) where CE is endemic was estimated from the results of previous surveys based on ultrasonography and/or chest X-rays (Schantz et al, 1973;Zabert et al, 1979;Frider et al, 1985Frider et al, , 1986Frider et al, , 1988bFrider et al, , 2001Mlika et al, 1986;Macpherson et al, 1987Macpherson et al, , 1989bSaint Martin et al, 1988;Larrieu et al, 1989;Perdomo et al, 1990Perdomo et al, , 1997Bchir et al, 1991;Shambesh et al, 1992Shambesh et al, , 1999Carmona et al, 1998;Cohen et al, 1998;Qiu et al, 1999;Wang et al, 1999) and a review of the results of general autopsy studies in Chile and Argentina (Schenone et al, 1971(Schenone et al, , 1973Frider et al, 1988a). The cyst locations noted in the hospital records of surgical cases of CE in Argentina, Australia, Bulgaria, Chile, Iran, Israel, Jordan, Turkey and Uruguay (Purriel et al, 1975;Varela Diaz et al, 1983;Isaacs et al, 1987;Macpherson et al, 1989a;Goldsmith et al, 1991;Larrieu et al, 1991;Kamhawi, 1995;Jenkins and Power, 1996;Daldal et al, 2001;Kurdova et al, 2001;Naem, 2001) were also investigated.…”

Section: Methodsmentioning

confidence: 99%

Human cystic echinococcosis: contributions to the natural history of the disease

Larrieu¹,

Frider

2001

Annals of Tropical Medicine And Parasitology

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In areas where human cystic echinococcosis (CE) is endemic, the results of ultrasonographic or X-ray examinations have revealed a surprisingly high prevalence of abdominal cysts in asymptomatic individuals. The results of preliminary studies indicate that the ratio of liver infection:lung infection (LI:LU) is much higher in the asymptomatic individuals (9:1 or 7:1) than is usual among symptomatic cases of liver CE (2:1). This difference may indicate that, compared with lung cysts, liver cysts rarely cause morbidity, perhaps because they grow at a slower rate than those in the lungs. In an attempt to explore this possibility, the published results of ultrasonographic and radiological surveys on general populations and the records of autopsies and hospital-based investigations of symptomatic cases of liver CE were reviewed. In general populations, the overall prevalence of cysts in the liver (2.5%) was found to be much higher than that of cysts in the lungs (0.3%), giving a LI:LU ratio of 8.3:1. In the symptomatic cases, however, LI:LU ratios were only 2.5:1 (based on hospital records) or 4.1:1 (based on autopsy records). In addition, the estimated mean growth rate of the cysts in 53 surgical cases of CE from the province of Río Negro in Argentina was found to be significantly higher than that of the cysts in 89 asymptomatic cases detected during ultrasonographic surveys in the same area.

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Section: Methodsmentioning

confidence: 99%

Human cystic echinococcosis: contributions to the natural history of the disease

Larrieu¹,

Frider

2001

Annals of Tropical Medicine And Parasitology

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“…La utilidad y la validez de la ecografía en el diagnóstico de la hidatidosis humana han sido ampliamente verificadas tanto en pacientes sintomáticos como en portadores asintomáticos (16)(17)(18)(19)(20)(21)(22). Desde el punto de vista de las imágenes ecográficas del quiste hidatídico, se consideran patognomónicas las siguientes características: a) vesículas aisladas; b) vesículas hijas múltiples; c) observación del "nevado" de la arenilla hidatídica al mover bruscamente al paciente 180 grados (20); d) aparición de membranas desprendidas, y e) pared del quiste hidatídico de mayor espesor que en los quistes serosos simples o en la enfermedad poliquística.…”

Section: Diagnóstico De Portadores Asintomáticos Mediante Ecografíaunclassified

“…Por ejemplo, en zonas endémicas merece prestarse especial atención al alto porcentaje de casos detectados entre los convivientes de personas operadas por hidatidosis, el cual es estadísticamente superior al de la población general (12,2% frente a 4,1%, P < 0,01). Debería también evaluarse la situación de las personas que tienen perros portadores de Echinococcus granulosus (20).…”

Section: Tamizado De Poblacionesunclassified

Portadores asintomáticos de hidatidosis: epidemiología, diagnóstico y tratamiento

Larrieu¹,

Frider²,

Carpio³

et al. 2000

Rev Panam Salud Publica

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Until a short time ago, hydatidosis was considered a pathology that could only be resolved surgically. However, in recent years progress has been made with the epidemiology, diagnosis, and treatment of the disease, and new information on the natural history of hydatidosis has helped define new criteria for its treatment. It is now known that as many as 67% of the carriers of liver cysts who are asymptomatic remain so throughout their lives. This situation produces special results in immunologic testing. Enzyme-linked immunosorbent assay (ELISA) has a sensitivity of 63% and a specificity of 97% with asymptomatic carriers, while the double diffusion arc 5 test (DD5) achieves a sensitivity of only 31% with the same population. On the other hand, imaging studies based on ultrasonography have become the method of choice to detect asymptomatic carriers. Ultrasonography studies are 49% to 73% more sensitive than serological tests, and they can even be used as a part of epidemiological surveillance systems and to monitor control programs. Treatment schemes have also been modernized. Treating asymptomatic carriers chemotherapeutically with albendazole produces favorable results in as many as 69% of cases, while such minimally invasive surgical treatments as puncture-aspiration-injection-reaspiration (PAIR) reduce average cyst volume by as much as 66%. These factors have made it possible for hospital services in the province of Río Negro, Argentina, to establish a treatment scheme for asymptomatic carriers. It is based on the monitoring of small cysts (type Ia on the modified Gharbi scale); initial treatment with albendazole, followed by PAIR if there is no response, in larger or more complex cysts (types Ib, II, and III); and follow-up of inviable or dead cysts (types IV and V).

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“…This study and other similar surveys using portable ultrasonography have provided valuable data about prevalence of cystic hydatid disease [5]; however, few studies have attempted to objectively reevaluate human echinococcosis cases detected as part of these surveys [6]. Field-based studies that incorporate serial evaluation of individuals with hydatidosis are important, as they (1) elucidate the natural history of hydatid disease; (2) monitor the response to medical or surgical treatment; (3) record growth rates and changes in morphology of cysts over time; and (4) detect the appearance of new cysts in previously cyst-negative seropositive subjects.…”

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confidence: 97%

Human Hydatidosis in the Central Andes of ‐Peru: Evolution of the Disease over 3 Years

et al. 1999

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To document the natural history of Echinococcus granulosus infection and response to treatment of human hydatidosis, we reexamined 28 of 37 subjects with E. granulosus infection diagnosed in an epidemiological study conducted in 1994. Twenty-six (70%) of those 37 subjects underwent abdominal ultrasonography, chest radiography, and enzyme-linked immunoelectrotransfer blot assay in 1997. Medical records from two additional individuals were reviewed. Eight patients had their cysts surgically removed during the 3-year follow-up interval; no surgical complications or recurrences occurred. Among eight patients with cystic disease not treated by surgery, four had cyst-growth ranging from 0.4 to 1.4 cm during the 3-year interval. One patient developed a new cyst and another's simple cyst became septate; two developed new calcifications. Of 12 seropositive subjects with no cysts present in 1994, 10 reverted to seronegative, a finding that suggests a significant proportion of seropositive subjects in echinococcus-endemic regions may have only transient infection without disease. When cysts do develop, their growth rates and time courses are highly variable; over the 3-year period, we observed growth, septation, degeneration, and calcification of cysts.

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Hidatidosis humana: ecografía de campo para la determinación de grupos de alto riesgo en la evaluación de un programa de control

Cited by 7 publications

References 0 publications

Human cystic echinococcosis: contributions to the natural history of the disease

Human cystic echinococcosis: contributions to the natural history of the disease

Portadores asintomáticos de hidatidosis: epidemiología, diagnóstico y tratamiento

Human Hydatidosis in the Central Andes of ‐Peru: Evolution of the Disease over 3 Years

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