1989
DOI: 10.1590/s0036-46651989000300003
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Abstract: SUMMARYA comparativ e stud y o f th e antigeni c profil e o f bloodstrea m an d cel l cultur e derived trypomastigote s showe d many difference s i n thei r components. Using mouse anti-T. cruz i antibodie s th e difference s wer e locate d mostl y i n th e 12 0 kDa band , whereas usin g chagasi c patien t ser a th e difference s wer e locate d i n th e 8 5 an d 5 2 kDa bands . These finding s migh t explai n know n physiologica l difference s betwee n trypomatigotes obtaine d fro m cel l cultur e an d fro m i… Show more

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Cited by 5 publications
(5 citation statements)
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“…The variation of the antigenic composition of the parasite associated with the particular immune response of each individual could result in the activation of different lymphocyte clones and in production of antibodies with different specificities. 29 A large number of T. cruzi Y strain antigens with apparent molecular weights ranging from 11 to 145 kD was recognized by serum samples from chagasic patients. However, differences in the molecular weights of the proteins recognized by sera have been observed when results from different studies are compared, and this may be due to variations in the measurement of the band migration on the gel.…”
Section: Discussionmentioning
confidence: 99%
“…The variation of the antigenic composition of the parasite associated with the particular immune response of each individual could result in the activation of different lymphocyte clones and in production of antibodies with different specificities. 29 A large number of T. cruzi Y strain antigens with apparent molecular weights ranging from 11 to 145 kD was recognized by serum samples from chagasic patients. However, differences in the molecular weights of the proteins recognized by sera have been observed when results from different studies are compared, and this may be due to variations in the measurement of the band migration on the gel.…”
Section: Discussionmentioning
confidence: 99%
“…Changes were detected after 30-50 days, by which time increases in the number and the intensities of certain antigens occurred, including components of approximately 50, 40 and 28 KDa. Antigens with similar molecular weights as these have been reported and some of them have been studied extensively [34][35][36][37][38][39]. Western blot analysis with antigens of epimastigotes from the five clones of T. cruzi were almost similar, suggesting that the major molecules may be represented in all clones of the organism.…”
Section: Discussionmentioning
confidence: 93%
“…One more characteristic of T. cruzi that might help to support present results is its great surface antigenic variation, allowing the host to produce Abs with different specificities. Such an activity should be attributed, in part, to the presence of T. cruzi-membrane glycoproteins, a potential antigenic component able to mediate in the expression of surface proteins with the capability to induce immunogenicity, an activity also demonstrated in Trypanosoma rangeli and Leishmania braziliensis (24)(25)(26)(27)(28)(29)(30).…”
Section: Discussionmentioning
confidence: 99%