Labeling of Salmonella Typhymurium with iodine-131 to study phagocytic function in rats

Sato, Mariana Eri; Rodrigues, Aldo Junqueira; Camargo, Edwaldo E.

doi:10.1590/s0036-46651989000300001

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“…Besides being only semiquantitative, this method has the disadvantage of not allowing continuous monitoring of liver RES function. A very common way of determining RES function in animals is to measure the clearance of radioactively marked bacteria like Escherichia coli [10,11] or salmonella [12], These methods are of course not suited for use in humans and do not enable the examination of the liver RES separately. A very good test seems to be the injection of supraparamagnetic iron oxide and determin ing its distribution with a nuclear spin tomo graph [13], but this method is difficult to access and very expensive.…”

Section: Introductionmentioning

confidence: 99%

Dynamic Liver Scintigraphy: A New Way of Measuring the Function of the Reticulo-endothelial System of the Liver

Baas

Senninger²,

Elser³

et al. 1995

Eur Surg Res

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The phagocytic function and biokinetics of the hepatic reticuloendothelial system (RES) were evaluated using a 25-nm diameter colloid (Nanocoll^TM) and a scintillation camera technique in opossums with obstruction of the pancreatic duct (group I) and additional obstruction of the common bile duct (group II). The liver net uptake curve was analysed using natural log regression. The regression curves proved to fit very well (r > 0.93) and a parameter R was calculated to describe the curves. In group I there was a slight but significant decrease in the RES function and no morphological change in the pancreas. In group II, RES function was significantly more suppressed than in group I. The opossums developed severe haemorrhagic pancreatitis. The results show that the regression parameter R is well suited to describe liver RES function, and suggest that a suppressed liver RES after biliary obstruction could be an important factor in the pathogenesis of biliary pancreatitis.

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Section: Introductionmentioning

confidence: 99%

Dynamic Liver Scintigraphy: A New Way of Measuring the Function of the Reticulo-endothelial System of the Liver

Baas

Senninger²,

Elser³

et al. 1995

Eur Surg Res

View full text Add to dashboard Cite

show abstract

Labeling of Salmonella Typhymurium with iodine-131 to study phagocytic function in rats

Abstract: SUMMARYThe presen t stud y describe s a metho d fo r labelin g Salmonell a typhymuriu m with iodine-13 1 t o evaluat e bot h th e morphologica l an d th e functiona l charad e ristics o f th e reticuloendothelia l system .

Cited by 1 publication

References 3 publications

Dynamic Liver Scintigraphy: A New Way of Measuring the Function of the Reticulo-endothelial System of the Liver

Dynamic Liver Scintigraphy: A New Way of Measuring the Function of the Reticulo-endothelial System of the Liver

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