Reinfections and rotavirus serotypes in Belém, Brazil

Abstract

Repeated infections involving different rotavirus serotypes were detected in four children living in Belém, who were followed up since birth to three years of age. In one child (Reg. 23.983) three successive symptomatic infections (one of them associated with serotype 2) were noted: the first, at four months of age, the second at 20 months and the third at 27 months. Another child had two subsequent infections, the first one by rotavirus serotype 1, and the second by a not identified rotavirus serotype. In this case two episodes of rotavirus-related diarrhoea were recorded, occurring eight months apart. Apparent infections were detected on two occasions involving the same child (Reg. 24.004), the first being associated with serotype 1, and the second with serotype 2. The fourth child (Reg. 24.097) had two successive infections by not determined rotavirus serotypes, without clinical manifestations; the first occurred at 24 months and the second at 28 months.

Epidemiologia das infecções por rotavírus no Brasil e os desafios para o seu controle

“…Em geral, à infecção envolvendo o sorotipo 1 sucedia-se outra pelo 2, nos primeiro e segundo anos de vida, respectivamente (Linhares et al, 1988a;Oliveira et al, 1994;Linhares, 1997).…”

G2 rotavirus infections in an infantile population of the South of Italy: Variability of viral strains over time

“…It is thought that homotypic immune response to rotavirus correlated with protection against severe diarrhea, and heterotypic antibodies within a genogroup may also be important for protection from secondary infections [Bishop et al, 1983;Offit, 1996;Velazquez et al, 1996]. Primary infections with G1 type followed by symptomatic infection with G2 type have been described by Linhares et al [1988] and symptomatic G2 infections in adults have also been reported [Timenetsky et al, 1996;Griffin et al, 2002]. In a study in South Africa, it was demonstrated that a temporal distribution with peaks in the prevalence of G2 strains after 10 years could be observed [Page and Steele, 2004a].…”