Strain variation in the infectivity of Schistosoma mansoni for Biomphalaria glabrata

Dias, Luiz Cândido de Souza; Bruce, J. I.; Coles, G.C.

doi:10.1590/s0036-46651988000200006

Cited by 5 publications

(2 citation statements)

References 12 publications

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“…Changes in the intermediate host strain and species have a reproducible phenotypic impact on the parasite, and more specifically on its life history traits (sex ratio, growth, prevalence and intensity of the infection) (Dias et al . ; Lepesant et al . ; Theron et al .…”

Section: Introductionmentioning

confidence: 99%

Frequency and mitotic heritability of epimutations in Schistosoma mansoni

et al. 2016

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Schistosoma mansoni is a parasitic platyhelminth responsible for intestinal bilharzia. It has a complex life cycle, infecting a freshwater snail of the Biomphalaria genus, and then a mammalian host. Schistosoma mansoni adapts rapidly to new (allopatric) strains of its intermediate host. To study the importance of epimutations in this process, we infected sympatric and allopatric mollusc strains with parasite clones. ChIP-Seq was carried out on four histone modifications (H3K4me3, H3K27me3, H3K27ac and H4K20me1) in parallel with genomewide DNA resequencing (i) on parasite larvae shed by the infected snails and (ii) on adult worms that had developed from the larvae. No change in single nucleotide polymorphisms and no mobilization of transposable elements were observed, but 58-105 copy number variations (CNVs) within the parasite clones in different molluscs were detected. We also observed that the allopatric environment induces three types of chromatin structure changes: (i) host-induced changes on larvae epigenomes in 51 regions of the genome that are independent of the parasites' genetic background, (ii) spontaneous changes (not related to experimental condition or genotype of the parasite) at 64 locations and (iii) 64 chromatin structure differences dependent on the parasite genotype. Up to 45% of the spontaneous, but none of the host-induced chromatin structure changes were transmitted to adults. In our model, the environment induces epigenetic changes at specific loci but only spontaneous epimutations are mitotically heritable and have therefore the potential to contribute to transgenerational inheritance. We also show that CNVs are the only source of genetic variation and occur at the same order of magnitude as epimutations.

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Section: Introductionmentioning

confidence: 99%

Frequency and mitotic heritability of epimutations in Schistosoma mansoni

et al. 2016

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“…In the case of the Brazilian strains the efficacy is generally more than 95% and other parameters show a high susceptibility to these schistosomicides (Dias et al 1982, 1988, Drescher et al 1993. Recently, Araújo et al (1996) studied ten isolates of S. mansoni derived from patients in an endemic area in Bahia, Brazil.…”

Section: Discussionmentioning

confidence: 99%

Altered Response of Strain of Schistosoma mansoni to Oxamniquine and Praziquantel

Bonesso-Sabadini

Dias

2002

Mem. Inst. Oswaldo Cruz

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Biological and morphological characteristics of Schistosoma mansoni from Ribeira Valley, State of São Paulo, Brazil: I - susceptibility of Biomphalaria tenagophila snail to sympatric S. mansoni strain

Figueiredo¹,

Dias²,

Marques³

1992

Rev. Inst. Med. trop. S. Paulo

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In the São Paulo State, Brazil, where the Biomphalaria tenagophila is the intermediate host, the Ribeira Valley is an important endemic schistosomiasis mansoni area. During last eleven years there has been intense control measures focusing on schistosomiasis. The efforts have been concentrated in the municipalities of Pedro de Toledo and Itariri. We determined the susceptibility of B. tenagophila to sympatric strain of S. mansoni, both recently isolated from Itariri field. In 1988, this strain was isolated and maintained in the experimental model: Swiss mice - sympatric B. tenagophila. The second generation of the worm was evaluated. The snail were divided in the three groups of 60 snails each. One group was exposed to 1 miracidium and other to 10. The third group was the control. The mortality and the shedding of cercariae were checked during 78 days. After that, the positive snails were observed until they ceased to shed cercariae. The exposed molluscs showed mortality rates of 23% and 31% and infection indexes were of 8% and 60% to 1 and 10 miracidia respectively. The mortality was of 22% in the control group. The periods of shedding cercariae in the two groups were 82 and 104 days. We can conclude that B. tenagophila is an effective intermediate host to the sympatric strain of S. mansoni sympatric strain

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Strain variation in the infectivity of Schistosoma mansoni for Biomphalaria glabrata

Cited by 5 publications

References 12 publications

Frequency and mitotic heritability of epimutations in Schistosoma mansoni

Frequency and mitotic heritability of epimutations in Schistosoma mansoni

Altered Response of Strain of Schistosoma mansoni to Oxamniquine and Praziquantel

Biological and morphological characteristics of Schistosoma mansoni from Ribeira Valley, State of São Paulo, Brazil: I - susceptibility of Biomphalaria tenagophila snail to sympatric S. mansoni strain

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