Paracoccidioidomicose enzoótica em tatus (Dasypus novemcinctus) no estado do Pará

Naiff, R. D.; Ferreira, Luíz Carlos Lima; Barrett, Toby Vincent; Naiff, M. F.; Árias, Jorge R.

doi:10.1590/s0036-46651986000100005

Cited by 105 publications

(51 citation statements)

References 7 publications

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“…It has been shown that these animals can be natural carriers of important pathogens such as Trypanosoma cruzi, 37,38 Histoplasma capsulatum, 39 Leishmania naiffi, 40 Toxoplasma gondii, 41 and Paracoccidioides brasiliensis. [42][43][44] The nine-banded armadillos, family Dasypodidae, order Cingulata, Superorder Xenarthra, 13 were introduced in North America very recently, around the year 1880. The human civilization, that probably appeared in Africa 400,000-200,000 years ago, arrived in America much later, being South America the last part of the continent to be colonized by man about 14,000 years ago.…”

Section: Discussionmentioning

confidence: 99%

Search for Mycobacterium leprae in wild mammals

Pedrini¹,

Rosa²,

Medri³

et al. 2010

Braz J Infect Dis

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Leprosy is still a worldwide public health problem. Brazil and India show the highest prevalence rates of the disease. Natural infection of armadillos Dasypus novemcinctus with Mycobacterium leprae has been reported in some regions of the United States. Identification of bacilli is difficult, particularly due to its inability to grow in vitro. The use of molecular tools represents a fast and sensitive alternative method for diagnosis of mycobacteriosis. In the present study, the diagnostic methods used were bacilloscopy, histopathology, microbiology, and PCR using specific primers for M. leprae repetitive sequences. PCR were performed using genomic DNA extracted from 138 samples of liver, spleen, lymph nodes, and skin of 44 D. novemcinctus, Euphractus sexcinctus, Cabassous unicinctus, and C. tatouay armadillos from the Middle Western region of the state of São Paulo and from the experimental station of Embrapa Pantanal, located in Pantanal da Nhecolândia of Mato Grosso do Sul state. Also, the molecular analysis of 19 samples from internal organs of other road killed species of wild animals, such as Nasua nasua (ring-tailed coati), Procyon cancrivoros (hand-skinned), Cerdocyon thous (dog-pity-bush), Cavia aperea (restless cavy), Didelphis albiventris (skunk), Sphigurrus spinosus (hedgehog), and Gallictis vittata (ferret) showed PCR negative data. None of the 157 analyzed samples had shown natural mycobacterial infection. Only the armadillo inoculated with material collected from untreated multibacillary leprosy patient presented PCR positive and its genomic sequencing revealed 100% identity with M. leprae. According to these preliminary studies, based on the used methodology, it is possible to conclude that wild mammals seem not to play an important role in the epidemiology of leprosy in the Middle Western region of the São Paulo state and in the Pantanal of Mato Grosso do Sul state.

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Section: Discussionmentioning

confidence: 99%

Search for Mycobacterium leprae in wild mammals

Pedrini¹,

Rosa²,

Medri³

et al. 2010

Braz J Infect Dis

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“…The demonstration of a high incidence of P. brasiliensis infection in the nine-banded armadillo, Dasypus novemcinctus, a wild mammal that typically has evolved in South America and lives immersed in soil [52][53][54][55][56][57][58], has opened new perspectives for comprehending the pathogen's ecology and evolution. In this animal species and also in the naked-tailed armadillo, Cabassous centralis [59], P. brasiliensis can be isolated regularly.…”

Section: Origin and Maintenance Of P Brasiliensis' Virulencementioning

confidence: 99%

Paracoccidioides brasiliensis: phylogenetic and ecological aspects

et al. 2008

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The knowledge on the biological aspects of Paracoccidioides brasiliensis has evolved greatly since the first description of the disease in 1908. From the pioneers, who were able to clearly demonstrate the fungal nature of the agent, to the recent genomic era, important advances have been achieved. P. brasiliensis is a true fungus, belonging to the Ascomycetous Division, although its sexual phase has not been demonstrated morphologically. A better understanding of the fundamental aspects of the agent, especially its phylogeny and evolutionary history, will provide us with valuable insights allowing a better comprehension of the disease and our capacity to deal with the problem. Concerning the fungus's ecology, although some progress had been observed, the ecological niche of the pathogen has not been determined yet. The aim of the present review is to focus on the biological aspects of P. brasiliensis from an evolutionary point of view, addressing the fungus's phylogenetic aspects, in those special points that might be relevant for the pathogen/ host interactions, the biological forces that have been acting on its origin and maintenance of virulence, as well as in determining the fungus's ecology and epidemiology.

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“…Furthermore, several patients with PCM seen at the UNESP University Hospital live in Pratania. Two of these isolates were collected from soil of armadillo's holes (Table II), an interesting finding that correlates with the isolation of the agent in Amazonian armadillos (Naiff et al 1986). We are in the process of studying the biology, antigenicity and virulence of these isolates as well as expanding the ecological survey to collect further soil samples from other armadillo holes.…”

Section: Discussionmentioning

confidence: 80%

“…+ Corresponding author. Fax: +55-14-821.2348 Received 18 January 1996 Accepted 6 August 1996 in internal organs of armadillos (Naiff et al 1986), the increased rate of positivity to paracoccidioidin in indians after they were exposed to dust from coffee plantations in a deforested area (Wanke et al 1992), all point to the soil as one of the most likely habitat of the fungus.…”

mentioning

confidence: 99%