Paracoccidioidomycosis in children with different skeletal involvement

Filho, Nelson Augusto Rosário; Filho, Flávio Queiroz-Telles; Costa, Orival; Marinoni, Leide Parolin

doi:10.1590/s0036-46651985000600007

Cited by 15 publications

(7 citation statements)

References 2 publications

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“…There are few publications in the literature on PCM articular involvement, and some are controversial in relation to their most frequently obtained findings 13,32 .…”

Section: Discussionmentioning

confidence: 99%

DOSE RESPONSE EFFECT OF Paracoccidioides brasiliensis IN AN EXPERIMENTAL MODEL OF ARTHRITIS

Loth

Biazim

Santos

et al. 2014

Rev. Inst. Med. trop. S. Paulo

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Paracoccidioidomycosis (PCM) is caused by the dimorphic fungus Paracoccidioides brasiliensis (Pb) and corresponds to prevalent systemic mycosis in Latin America. The aim of the present work was to evaluate the dose response effect of the fungal yeast phase for the standardization of an experimental model of septic arthritis. The experiments were performed with groups of 14 rats that received doses of 103, 104 or 105 P. brasiliensis (Pb18) cells. The fungi were injected in 50 µL of phosphate-buffered saline (PBS) directly into the knee joints of the animals. The following parameters were analyzed in this work: the formation of swelling in knees infused with yeast cells and the radiological and anatomopathological alterations, besides antibody titer by ELISA. After 15 days of infection, signs of inflammation were evident. At 45 days, some features of damage and necrosis were observed in the articular cartilage. The systemic dissemination of the fungus was observed in 11% of the inoculated animals, and it was concluded that the experimental model is able to mimic articular PCM in humans and that the dose of 105 yeast cells can be used as standard in this model.

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“…There are few publications in the literature on PCM articular involvement, and some are controversial in relation to their most frequently obtained findings 13,32 .…”

Section: Discussionmentioning

confidence: 99%

DOSE RESPONSE EFFECT OF Paracoccidioides brasiliensis IN AN EXPERIMENTAL MODEL OF ARTHRITIS

Loth

Biazim

Santos

et al. 2014

Rev. Inst. Med. trop. S. Paulo

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“…Differently from some studies in the literature ( 3 , 5 , 18 ) , the authors have identified the presence of fine reactive osteosclerosis in the margins of 72.22% (13/18) of the bone lesions ( Figures 2 and 3), and the mean time between the disease onset symptoms and the imaging study was 6.33 months (ranging between 3 and 12 months). Other authors have also identified marginal osteosclerosis in part of bone lesions ( 14 , 17 , 19 , 23 ) . The authors of the present study assume that their results might be explained, at least partially by the utilization of sectional images and by the CT images high resolution, which may have provided higher sensitivity in the detection of subtle abnormalities as compared with other studies which utilized only plain radiography.…”

Section: Discussionmentioning

confidence: 92%

“…A previous history of either blunt or open trauma preceding osteoarticular manifestations made the fungus dissemination easier in the phase of fungemia ( 7 , 18 , 23 ) , a phenomenon called locus minoris resistentiae ( 23 ) , which should not be interpreted as an agent inoculation factor.…”

Section: Discussionmentioning

confidence: 99%

Computed tomography findings of paracoccidiodomycosis in musculoskeletal system

et al. 2015

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ObjectiveTo evaluate musculoskeletal involvement in paracoccidioidomycosis at computed tomography.Materials and MethodsDevelopment of a retrospective study based on a review of radiologic and pathologic reports in the institution database. Patients with histopathologically confirmed musculoskeletal paracoccidioidomycosis and submitted to computed tomography were included in the present study. The imaging findings were consensually described by two radiologists. In order to avoid bias in the analysis, one patient with uncountable bone lesions was excluded from the study.ResultsA total of seven patients were included in the present study. A total of 18 bone lesions were counted. The study group consisted of 7 patients. A total number of 18 bone lesions were counted. Osteoarticular lesions were the first manifestation of the disease in four patients (57.14%). Bone lesions were multiple in 42.85% of patients. Appendicular and axial skeleton were affected in 85.71% and 42.85% of cases, respectively. Bone involvement was characterized by well-demarcated osteolytic lesions. Marginal osteosclerosis was identified in 72.22% of the lesions, while lamellar periosteal reaction and soft tissue component were present in 5.55% of them. One patient showed multiple small lesions with bone sequestra.ConclusionParacoccidioidomycosis can be included in the differential diagnosis of either single or multiple osteolytic lesions in young patients even in the absence of a previous diagnosis of pulmonary or visceral paracoccidioidomycosis

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“…Bone lesions have been less frequently described and are usually part of a multisystem clinical picture 10, 11. Exclusive bone involvement is a rare presentation for PCM.…”

Section: Discussionmentioning

confidence: 99%

Fungal infection by Paracoccidioides brasiliensis mimicking bone tumor

Valera

Mori

Engel

et al. 2008

Pediatric Blood & Cancer

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Paracoccidioides brasiliensis infection causes a systemic mycosis originally described in Latin America but with current reports of worldwide distribution. The clinical presentation of paracoccidiodomycosis as an isolated long-bone lesion in children is quite unusual. This article describes a 10-year-old male with a lytic femoral bone lesion caused by P. brasiliensis infection that was first suspected of being of neoplasic etiology. The text also emphasizes the importance of including endemic fungal infections in the differential diagnosis of bone lesions.

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Paracoccidioidomycosis in children with different skeletal involvement

Cited by 15 publications

References 2 publications

DOSE RESPONSE EFFECT OF Paracoccidioides brasiliensis IN AN EXPERIMENTAL MODEL OF ARTHRITIS

DOSE RESPONSE EFFECT OF Paracoccidioides brasiliensis IN AN EXPERIMENTAL MODEL OF ARTHRITIS

Computed tomography findings of paracoccidiodomycosis in musculoskeletal system

Fungal infection by Paracoccidioides brasiliensis mimicking bone tumor

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