Registro de um caso de paracoccidioidomicose no Japão

Chikamori, Taishiro; Saka, Satoshi; Nagano, Hiroshi; Saeki, Shigeru; Lacaz, Carlos da Silva; Rodrigues, Maria Conceição; Cassaguerra, Cintia Marzagão; Braccialli, Maria Luisa

doi:10.1590/s0036-46651984000500007

Cited by 7 publications

(1 citation statement)

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“…Os casos relatados nos EUA, África, Europa e Ásia são conhecidos como doença de importação, devido ao fato dos pacientes terem residido em regiões endêmicas em época anterior à manifestação clínica da micose (FERGUSON e UPTON, 1974;FOUNTAIN e SUTHIFF, 1969;CHICAMORI et al, 1984;AJELLO e POLINELLI, 1985).…”

Section: Somente Dois Indivíduos Não Tiveram Contato Anterior Com O Munclassified

Terapia gênica contra Paracoccidioidomicose experimental utilizando camundongos BALB/c e B10.A e vetores de expressão de P10, HSP60 e IL-12.

Rittner¹

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Section: Somente Dois Indivíduos Não Tiveram Contato Anterior Com O Munclassified

Terapia gênica contra Paracoccidioidomicose experimental utilizando camundongos BALB/c e B10.A e vetores de expressão de P10, HSP60 e IL-12.

Rittner¹

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Imported paracoccidioidomycosis : A public health problem in non-endemic areas

Ajello

Polonelli

1985

Eur J Epidemiol

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Diagnosis of paracoccidioidomycosis in an immigrant who had returned to Italy following a long sojourn in Venezuela prompted a review of imported cases of this Latin American disease in nonendemic countries. Forty-two such instances of well-documented paracoccidioidomycosis were complied. Among these, eleven individuals had arrived in nonendemic countries with active symptomatic infections, fifteen others were first suspected of having tuberculosis, and four each were considered to have blastomycosis caused by Blastomyces dermatitidis and carcinomas. Three individuals were considered to have Wegener's granulomatosis or blastomycosis. Two other patients were treated for syphilis before being diagnosed as having paracoccidioidomycosis. A striking feature of most of these cases was the long asymptomatic period following initial infection. The dormant periods ranged form four months to 60 years with an average duration of 14 years. The need to question patients about travel to or residency in foreign countries is emphasized, along with the necessity to include the mycoses in differential diagnoses. Three reported cases, all from Africa with no history of travel to the endemic areas of the New World, were considered to be doubtful. In one of these, Russell bodies apparently had been mistaken for the tissue-form cells of Paracoccidioides brasiliensis.(ABSTRACT TRUNCATED AT 250 WORDS)

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An overview of the immunopathology of human paracoccidioidomycosis

2008

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We review here the advances in the understanding of the immunopathology of human paracoccidioidomycosis (PCM). Its investigation must take in account the intriguing natural history of the mycosis and its agent, providing clues to the mechanisms that lead to development of disease (unbalanced host-parasite relationship?) or to the clinically silent, chronic carrier state (balanced hostparasite relationship?), in exposed people living in endemic areas. Although the literature on this subject has progressed notably, the overall picture of what are the mechanisms of susceptibility or resistance continues to be fragmentary. Major advances were seen in the description of both the cytokines/chemokines associated to the different outcomes of the hostparasite interaction, and the fungus-monocyte/macrophage interaction, and cytokines released thereof by these cells. However, relatively few studies have attempted to modify, even in vitro, the patients' unbalanced immune reactivity. Consequently, the benefits of this improved knowledge did not yet reach clinical practice. Fortunately, the previous notion of the immune system as having two nearly independent arms, the innate and adaptive immunities, leaving a large gap between them, is now being overcome.Immunologists are now trying to dissect the connections between these two arms. This will certainly lead to more productive results. Current investigations should address the innate immunity events that trigger the IL-12/IFN-c axis and confer protection against PCM in those individuals living in endemic areas, who have been infected, but did not develop the mycosis.

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Registro de um caso de paracoccidioidomicose no Japão

Cited by 7 publications

References 0 publications

Terapia gênica contra Paracoccidioidomicose experimental utilizando camundongos BALB/c e B10.A e vetores de expressão de P10, HSP60 e IL-12.

Terapia gênica contra Paracoccidioidomicose experimental utilizando camundongos BALB/c e B10.A e vetores de expressão de P10, HSP60 e IL-12.

Imported paracoccidioidomycosis : A public health problem in non-endemic areas

An overview of the immunopathology of human paracoccidioidomycosis

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