Estudo histopatológico das lesões causadas pelo veneno de urutu (Bothrops alternatus) em músculo esquelético de camundongos

Queiroz, Lorena Lauren Chaves; Petta, Carlos Alberto

doi:10.1590/s0036-46651984000500004

Cited by 20 publications

(4 citation statements)

References 2 publications

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“…Experimental studies with viperid snake venoms have shown that, in addition to acute skeletal muscle damage, they induce vascular and nerve alterations, as well as ECM degradation, within muscle tissue [ 62 , 78 , 79 ]; in this context, there is generally a poor muscle regenerative response [ 61 , 62 , 80 , 81 , 82 , 83 ]. Viperid snake venoms comprise, in addition to myotoxic PLA 2 s, other types of toxins which affect various components of skeletal muscle besides muscle fibers.…”

Section: Experimental Studies Of Muscle Regeneration After Myonecrmentioning

confidence: 99%

“…Likewise, fragments of basement membrane proteins are detected by Western blot and in proteomic analyses of exudates collected in the vicinity of muscle tissue injected with B. asper venom and a hemorrhagic SVMP [ 72 , 94 , 95 ]. Moreover, necrosis of smooth muscle in the wall of intramuscular arteries has been described after injection of viperid venoms or hemorrhagic SVMPs [ 48 , 78 , 81 , 90 , 96 ]. Such drastic alterations in the muscle vascular network are likely to contribute to the deficient regenerative process, since an adequate blood supply is a requisite for successful muscle regeneration [ 32 , 97 ].…”

Section: The Key Role Of Vascular Damage and Its Implications In Tmentioning

confidence: 99%

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Why is Skeletal Muscle Regeneration Impaired after Myonecrosis Induced by Viperid Snake Venoms?

Gutiérrez

Escalante

Hernández

et al. 2018

Toxins

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Skeletal muscle regeneration after myonecrosis involves the activation, proliferation and fusion of myogenic cells, and a coordinated inflammatory response encompassing phagocytosis of necrotic cell debris, and the concerted synthesis of cytokines and growth factors. Myonecrosis often occurs in snakebite envenomings. In the case of venoms that cause myotoxicity without affecting the vasculature, such as those of many elapid snakes, regeneration proceeds successfully. In contrast, in envenomings by most viperid snakes, which affect the vasculature and extracellular matrix in addition to muscle fibers, regeneration is largely impaired and, therefore, the muscle mass is reduced and replaced by fibro-adipose tissue. This review discusses possible causes for such poor regenerative outcome including: (a) damage to muscle microvasculature, which causes tissue hypoxia and affects the inflammatory response and the timely removal of necrotic tissue; (b) damage to intramuscular nerves, which results in atrophy of regenerating fibers; (c) degradation of muscle cell basement membrane, compromising the spatial niche for proliferating myoblasts; (d) widespread degradation of the extracellular matrix; and (e) persistence of venom components in the damaged tissue, which may affect myogenic cells at critical points in the regenerative process. Understanding the causes of poor muscle regeneration may pave the way for the development of novel therapeutic interventions aimed at fostering the regenerative process in envenomed patients.

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Section: Experimental Studies Of Muscle Regeneration After Myonecrmentioning

confidence: 99%

Section: The Key Role Of Vascular Damage and Its Implications In Tmentioning

confidence: 99%

Why is Skeletal Muscle Regeneration Impaired after Myonecrosis Induced by Viperid Snake Venoms?

Gutiérrez

Escalante

Hernández

et al. 2018

Toxins

View full text Add to dashboard Cite

show abstract

“…On the other hand, no reaction was found in the muscles from the control group ( Figure 2B). A small IM dose of B. alternatus venom (80μg) causes intense local hemorrhage and severe local myonecrosis in the first 24 hours (Queiroz and Petta, 1984). Similarly, low doses, ranging from 50 to 100μg, administered in the gastrocnemius muscle of mice caused severe changes in the local vasculature, culminating in hemorrhage, evident inflammation and myonecrosis, with recovery at 28 days (Garcia Denegri et al, 2016).…”

mentioning

confidence: 99%

Bothrops alternatus snake venom induces apoptosis of skeletal muscle cells in a rabbit model

Santos

Silveira

Fiúza

et al. 2019

Arq. Bras. Med. Vet. Zootec.

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“…Popularmente, a peçonha da serpente B. alternatus é conhecida por causar graves acidentes, por isso foi criado o ditado "quando não mata, aleija". Contudo, contrariando a crença popular, estudos têm demonstrado que acidentes causados por essa serpente não são tão graves, se comparado com acidentes causados por outras serpentes botrópicas (BAUAB et al, 1994;PETTA, 1984). A peçonha dessa espécie possui uma menor atividade enzimática, causando menores complicações (CAMPOS et al, 2013;MAMEDE et al, 2016;ROCHA;FURTADO, 2005;SOUZA et al, 2015).…”

Section: Serpente Bothrops Moojeniunclassified

Identificação e caracterização de peptídeos da peçonha de serpentes botrópicas que interferem na agregação plaquetária

Simamoto¹

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Cys-rich -domínio rico em cisteína COX-1 -cicloxigenase-1 CRD -Domínio de reconhecimento ao carboidrato DFP -Diisopropilfluorofosfato Dis -domínio desintegrina Dis-like -domínio semelhante à desintegrina EDTA -Ácido etilenodiaminotetracético FAD -Flavina adenina dinucleotídeo FMN -Flavina mononucleotídeo FvW -Fator de von Willebrand GP -Glicoproteína H2O2 -Peróxido de hidrogênio LAAO -L-aminoácido-oxidase mRNA -RNA mensageiro NGF -Fator de crescimento neuronal OMS -Organização Mundial da Saúde PARs -Receptores ativados por proteases PDGF -Fator de crescimento derivado de plaquetas PMSF -Fluoreto de fenilmetilsulfonilo PLA2 -Fosfolipase A2 PARs -receptores ativados por proteases SAB -Soro antibotrópico SABC -Soro antibotrópico-crotálico SABL -Soro antibotrópico-laqético Sinan -Sistema de Informação de Agravos e Notificação Snaclecs -do inglês, snake C-type lectins SV-LAAO -L-aminoácido-oxidases de peçonha de serpentes

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Estudo histopatológico das lesões causadas pelo veneno de urutu (Bothrops alternatus) em músculo esquelético de camundongos

Cited by 20 publications

References 2 publications

Why is Skeletal Muscle Regeneration Impaired after Myonecrosis Induced by Viperid Snake Venoms?

Why is Skeletal Muscle Regeneration Impaired after Myonecrosis Induced by Viperid Snake Venoms?

Bothrops alternatus snake venom induces apoptosis of skeletal muscle cells in a rabbit model

Identificação e caracterização de peptídeos da peçonha de serpentes botrópicas que interferem na agregação plaquetária

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