2013
DOI: 10.1590/s0034-8910.2013047004529
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Antivirais incorporados no Brasil para hepatite B cronica: analise de custo-efetividade

Abstract: OBJECTIVE:To evaluate the cost-effectiveness of different drug therapies for chronic hepatitis B in adult patients. METHODS:Using a Markov model, a hypothetical cohort of 40 years for HBeAg-positive or HBeAg-negative patients was constructed. Adefovir, entecavir, tenofovir and lamivudine (with rescue therapy in cases of viral resistance) were compared for treating adult patients with chronic hepatitis B undergoing treatment for the first time, with high levels of alanine aminotransferase, no evidence of cirrho… Show more

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Cited by 5 publications
(3 citation statements)
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“…Articles on the evaluation of medicines acquisition, from cost effectiveness studies, were published recently on RSP 2 , 39 , 70 . This approach is one of those used by Health Economics, topic that gathered the greatest number of articles in the area of PPM in these first five decades of RSP.…”
Section: Resultsmentioning
confidence: 99%
“…Articles on the evaluation of medicines acquisition, from cost effectiveness studies, were published recently on RSP 2 , 39 , 70 . This approach is one of those used by Health Economics, topic that gathered the greatest number of articles in the area of PPM in these first five decades of RSP.…”
Section: Resultsmentioning
confidence: 99%
“…Pacientes com Hepatite B podem cursar com doença hepática progressiva, que pode acarretar em cirrose e carcinoma hepatocelular, cuja incidência gira em torno de 25% nos recém-nascidos portadores do vírus e de 15% nos adultos. Devido isso a importância que se deve dar à imunização dos recém-nascidos nas primeiras 24 horas de vida 2,5 . Tais estágios da patologia estão ligados a maiores riscos de morbidade e mortalidade, além de implicarem consideráveis gastos em saúde 2 .…”
Section: Introductionunclassified
“…Devido isso a importância que se deve dar à imunização dos recém-nascidos nas primeiras 24 horas de vida 2,5 . Tais estágios da patologia estão ligados a maiores riscos de morbidade e mortalidade, além de implicarem consideráveis gastos em saúde 2 .…”
Section: Introductionunclassified