Contribuição do Mismatch Negativity na avaliação cognitiva de indivíduos portadores de esclerose múltipla

Santos, Marco Aurélio Rocha; Munhoz, Mário Sérgio Lei; Peixoto, Marco Aurélio Lana; Haase, Vítor Geraldi; Rodrigues, Jussara L.; Resende, Luciana Macedo de

doi:10.1590/s0034-72992006000600011

Cited by 13 publications

(12 citation statements)

References 18 publications

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“…The mean latency found in verbal and nonverbal stimuli was observed where the MMN valley is traditionally found. Thus, it can be said that the latency variation in most of the stimuli was compatible with 100 to 250 milliseconds, as already demonstrated in many studies, 4,5,20,[28][29][30][31][32] and also for the da/ ta stimuli, compatible with what has been referenced by other authors, 33 who suggest a variation from 150 to 275 milliseconds.…”

Section: Discussionsupporting

confidence: 87%

“…[1][2][3] Mismatch negativity is generated when the individual automatically discriminates a sound change, in which the auditory system is based on memory traces of the regularity of a sound stimulus, and detects a change, regardless of his/her attention. 1,4,5 This potential can be realized with several types of stimuli, among them the nonverbal sound stimulus (tone burst), in which the stimuli differ in frequency, intensity or duration, or with verbal stimuli, using a syllabic set (consonant/vowel). 5 Mismatch negativity is a useful exam to investigate neural mechanisms or to complement the audiological evaluation, thus it may also be valuable in the study of the auditory stimulus processing in the cortex 3 and to be used for monitoring and prognosis in auditory rehabilitation processes.…”

Section: Introductionmentioning

confidence: 99%

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Mismatch Negativity Occurrence with Verbal and Nonverbal Stimuli in Normal-Hearing Adults

Bruckmann

Garcia

2020

Int Arch Otorhinolaryngol

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IntroductionThe mismatch negativity (MMN) is a long-latency auditory evoked potential related to a passive elicited auditory event.Objective To verify the occurrence of MMN with different stimuli, to describe reference values in normal-hearing adults with verbal and nonverbal stimuli and to compare them with each other, besides analyzing the latency, area, and amplitude regarding gender and between the ears. Method Normal-hearing individuals, aged between 18 and 59 years old, participated in the study. As inclusion criterion in the study, all of them underwent tone threshold audiometry, logoaudiometry, tympanometry, and the Dichotic Sentence Identification (DSI) test, and later the MMN with 4 different stimuli, being 2 verbal (da/ta and ba/di) and 2 nonverbal stimuli (750/1,000Hz and 750/4,000Hz), which are considered stimuli with low and high contrast.Results A total of 90 individuals composed the sample, being 39 males and 51 females, with an average age of 26.9 years old. In the analysis of the latency, amplitude, and area of the four stimuli between the ears, they were not considered statistically different. There was a significant difference between all of the stimuli in terms of latency, amplitude and area, with the highest latency found in da/ta, and the greatest amplitude and area in ba/di. Regarding gender, there was only difference in the latency of the da/ta stimulus. Conclusion The da/ta and 750/1,000Hz stimuli elicited the most MMN in the population of normal-hearing adults. Among the genders, there was difference only regarding the latency of the verbal stimulus da/ta, and there was no difference between the ears.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Mismatch Negativity Occurrence with Verbal and Nonverbal Stimuli in Normal-Hearing Adults

Bruckmann

Garcia

2020

Int Arch Otorhinolaryngol

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“…Such data was not discussed in our study. Other authors 25,26 advocate the idea that the perception of simultaneous sounds is made difficulty with the normal aging of the population, and this is the method of presentation of stimuli in the MMN test. In the literature studied we did not find MMN studies with elderly citizens showing latency and amplitude values.…”

Section: Discussionmentioning

confidence: 99%

Verificação das respostas do Mismatch Negativity (MMN) em sujeitos idosos

Buranelli¹,

Barbosa²,

Garcia³

et al. 2009

Braz. j. otorhinolaryngol. (Impr.)

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Mi smatch Negativity is an endogenous potential which reflects the processing of differences incurred in the acoustic stimulus. Aim: to characterize MMN responses in elderly subjects and compare with adult subjects. Materials and methods: prospective study involving 30 subjects, 15 men and 15 women, aged between 60 and 80 years and 11 months. Statistical test: Mann-Whitney. The subjects went through medical evaluation, threshold tonal audiometry, immittance tests, otoacoustic emissions and short and long latency auditory potentials (MMN). Results: mean latency was 161.33 ms (CZA2) and 148.67 ms (CZA1), in women; of 171 ms (CZA2) and 159.07 ms (CZA1), men. Mean amplitude was -2.753 μV (CZA2) and -2.177 μV (CZA1), women; -1.847 μV (CZA2) and -1.953 μV (CZA1), men. As to the right and left hemispheres, mean latency variable of 166 ms (CZA2) and 153.87 ms (CZA1); for the amplitude variable, mean value of -2.316 μV (CZA2) and -2.065 μV (CZA1). Conclusion: there is no statistically significant difference between the latency and amplitude when we compared males and females, right and left sides in the elderly and between chronologic ages between adults and elderly subjects.

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“…This potential is generated at the moment the subject discriminate a sound change automatically. This occurs because the auditory system is based on memory traces of the regularity of a stimulus, detecting a change, independent of the attention of the subject 5,6 . Such potential is represented by a negative deflection or a valley that happens after the identification response of the different stimulus, which may occur approximately between 150 and 250 milliseconds (ms) after the stimulus presentation, depending on the used stimulus, which can be, in general, a pure tone or a speech stimulus 5 .…”

Section: Introductionmentioning

confidence: 99%

Aplicabilidade do mismatch negativity em crianças e adolescentes: uma revisão descritiva

et al. 2016

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The Mismatch Negativity (MMN) is a cortical potential that occurs in response to an acoustic stimulus modification amid a repeated stimuli sequence, which reflects the brain capacity of discriminate the sound passively, in other words, without necessity the individual attention to the sound stimulus. The purpose of this study is to perform a descriptive revision about MMN, in order to identify its applicability in child and youth, in the last five years. The search was realized in the database Lilacs, SciELO, Medline and Pubmed using the following key words: Auditory Cortex, Electrophysiology and Auditory Evoked Potentials. Besides that, the words Mismatch and Negativity were used. In this revision, it were found 14 studies which evaluated child and/or youth presenting difficulties in speech articulation, specific language impairment, auditory processing disorder, Attention Deficit and Hyperactivity Disorder, dyslexia, autism, schizophrenia, psychosis, amusia, phenylketonuria and selective attention. It was possible to perform the descriptive revision about the application of MMN in child and youth, concluding that in the last five years there were a reasonable article production about the theme, however, in Brazil, there are a few studies. There is a variety of applications to MMN, though; in the national population, there is a need for scientific evidences to use this potential in the different age groups. It was found, as well, that the search for MMN studies in the databases could be done only using the word Mismatch and Negativity. RESUMOO Mismatch Negativity (MMN) é um potencial cortical que ocorre em resposta a uma mudança de um estímulo acústico em meio a uma sequência de repetidos estímulos, o que reflete a capacidade do cérebro em discriminar o som de modo passivo, ou seja, sem a necessidade de atenção do indivíduo ao estímulo sonoro. Diante disso, o objetivo deste estudo foi realizar uma revisão descritiva sobre o MMN, a fim de identificar a sua aplicabilidade em crianças e adolescentes nos últimos cinco anos. Para isso, realizou-se uma busca nas bases de dados Lilacs, SciELO, Medline e Pubmed utilizando os seguintes descritores: córtex auditivo, eletrofisiologia, potenciais evocados auditivos e as palavras Mismacth e Negativity. Nesta revisão, foram encontrados 14 estudos que avaliaram crianças e/ou adolescentes com dificuldade de articulação na fala, distúrbio específico de linguagem, transtorno do processamento auditivo, Transtorno do Déficit de Atenção e Hiperatividade (TDAH), dislexia, autismo, risco para esquizofrenia, psicose, amusia, fenilcetonúria e atenção seletiva. Foi possível, assim, realizar a revisão descritiva sobre a aplicação do MMN em crianças e adolescentes, concluindo-se que, nos últimos cinco anos, houve uma produção considerável de artigos sobre o tema, embora no Brasil a presença de estudos a esse respeito ainda seja escassa. Nesse sentido, apesar de existir uma variedade de aplicações para o MMN, no que diz respeito à população brasileira, necessita-se ainda de evidências cient...

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Contribuição do Mismatch Negativity na avaliação cognitiva de indivíduos portadores de esclerose múltipla

Cited by 13 publications

References 18 publications

Mismatch Negativity Occurrence with Verbal and Nonverbal Stimuli in Normal-Hearing Adults

Mismatch Negativity Occurrence with Verbal and Nonverbal Stimuli in Normal-Hearing Adults

Verificação das respostas do Mismatch Negativity (MMN) em sujeitos idosos

Aplicabilidade do mismatch negativity em crianças e adolescentes: uma revisão descritiva

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