Citocinas e dor

Abstract

Summary: de Oliveira CMB, Sakata RK, Issy AM, Gerola LR, Salomão R -Cytokines and Pain. Background and objectives:Cytokines are necessary for the inflammatory response, favoring proper wound healing. However, exaggerated proinflammatory cytokine production can manifest systemically as hemodynamic instability or metabolic derangements. The objective of this review was to describe the effects of cytokines in pain.

Anti-Inflammatory Cytokines in Sepsis: Immunological Studies and In Silico Investigation

“…The anti-inflammatory action of this cytokine limits excessive tissue damage in infectious conditions be they viral or bacterial. It is responsible for establishing control of the inflammatory activity mediated by Th1 cells inhibiting pro-inflammatory cytokinesespecially tumor necrosis factor (TNF), IL-1, and IL-6 -produced by macrophages and activated monocytes, stimulating the endogenous production of anti-inflammatory cytokines [19].…”

“…IL-4 is a 15 kDa glycoprotein with action on mast cells, T and B lymphocytes, NK cells, synoviocytes, and endothelial cells through the JAK/STAT pathway [19]. This cytokine plays a fundamental role in cell growth and survival, with regulating action on T lymphocyte differentiation -especially during the immune response -in addition to having been shown to function as a factor in the differentiation of B cells.…”

“…Its protective antiinflammatory effect in chronic illness -such as diabetes mellitus and rheumatoid arthritis -is being investigated, opening possibilities for its role as a potential factor in the treatment of auto-immune diseases [21][22]. IL-13 is an anti-inflammatory cytokine produced mainly by T-CD4 cells of the Th2 subtype [19]. It has a dominant role in parasite immunity, asthma mediation, and resistance to intracellular microorganisms [23].…”

“…It acts by inhibiting the production of nitric oxide and various other cytokines produced by B lymphocytes and monocytes. It has stimulating action on the production of IL-1RA [19]. It also has an important function in inhibiting monocyte production of IL-1, IL-6, IL-8, and TNF-α, via the IL-1 receptor antagonist [23].…”

Efeito da suplementação de simbióticos sobre a inflamação sistêmica de idosos

“…Citocinas próinflamatórias Citocinas anti-inflamatórias IL-1, IL-1β, IL-2, IL-6, IL-7 e TNF-α IL-4, IL-10, IL-11 e IL-13 Fonte: Curfs et al, 1997;Zhang & An, 2007;Oliveira et al, 2011. Diante de tudo isso, cabe lembrar que a inflamação aguda é uma resposta do organismo a um possível estressor e/ou danos e, portanto é desejável, e que em indivíduos saudáveis, ou em condições consideradas "normais", ela cessa após a eliminação do agente causador.…”