2009
DOI: 10.1590/s0034-70942009000100005
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Oral Midazolam as Pre-Anesthetic Medication in Children and Teenagers with Cerebral Palsy. A Comparative Study on the Variations of the Bispectral Index

Abstract: Midazolam, used as pre-anesthetic medication, at a dose of 0.6 mg.kg(-1), reduced basal EEG-BIS without characterizing hypnosis and without statistically significant differences between the study groups.

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Cited by 2 publications
(2 citation statements)
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“…Costa et al (15) found that BIS values were lower after premedication with oral midazolam in children with CP than in normal children, however, contrary to our findings, this difference was not statistically significant. This controversy may be due to a variety of reasons including; the inclusion of only CP patients who were unable to speak and communicate and had severe mental retardation, whereas Costa et al (15) ) the BIS values of children are at levels that may be suggestive of mild sedation.…”
Section: Discussioncontrasting
confidence: 99%
“…Costa et al (15) found that BIS values were lower after premedication with oral midazolam in children with CP than in normal children, however, contrary to our findings, this difference was not statistically significant. This controversy may be due to a variety of reasons including; the inclusion of only CP patients who were unable to speak and communicate and had severe mental retardation, whereas Costa et al (15) ) the BIS values of children are at levels that may be suggestive of mild sedation.…”
Section: Discussioncontrasting
confidence: 99%
“…2,3 The current study encompasses a wider spectrum of patients labeled under the term Bintellectually disabled. 5 The effect of midazolam on F-aminobutyric acid receptor activity corresponds with the anticonvulsant and spasmolytic medications described in this study. One problem, however, with this study is that it did not grade the severity of the intellectual impairment in these children.…”
Section: Commentsupporting
confidence: 59%