2006
DOI: 10.1590/s0034-70942006000200006
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Abstract: Lidocaine increases the neuromuscular blocking produced by rocuronium. MEPP modifications identify a presynaptic action. The complete antagonism of 4-aminopyridine indicates a presynaptic component. This idea is supported by the partial antagonism through neostigmine.

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Cited by 9 publications
(6 citation statements)
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“…In electrophysiological studies, we observed that local anesthetics in the used concentration didn't produce alterations in muscular fibers membrane potential measures, staying above -82 milivolts, therefore inside of the normality limits, results similar to described for other authors 9 . In agreement with described by Bowman 20 , it can be inferred that these drugs doesn't possess depolarizing action on muscular fiber, that its action mechanism in the neuromuscular junction is not related to the muscular membrane stability activity, but they impede action potentials spread transport, without affecting the membrane potential.…”
Section: Discussionsupporting
confidence: 88%
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“…In electrophysiological studies, we observed that local anesthetics in the used concentration didn't produce alterations in muscular fibers membrane potential measures, staying above -82 milivolts, therefore inside of the normality limits, results similar to described for other authors 9 . In agreement with described by Bowman 20 , it can be inferred that these drugs doesn't possess depolarizing action on muscular fiber, that its action mechanism in the neuromuscular junction is not related to the muscular membrane stability activity, but they impede action potentials spread transport, without affecting the membrane potential.…”
Section: Discussionsupporting
confidence: 88%
“…Besides the likeness to the receivers, this stereoisomerism is also factor that contributes to the cellular membranes fluidly 19 . The results of this study resemble each other to the experimental and clinical researches [2][3][7][8][9][11][12][16][17] that also demonstrated that local anesthetics employed separately for different routes, don't commit neuromuscular transmission, but they potentiate neuromuscular blockade produced for different neuromuscular blocking.…”
Section: Discussionsupporting
confidence: 81%
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“…Among these drugs are local anesthetics, volatile anesthetic agents, antibiotics aminoglycosides, anticonvulsants, antiarrhythmic, magnesium, lithium, calcium channel blockers and others [1][2][3][4][5][6][7][8][9][10][11][12] . Although countless studies have been accomplished to investigate anticonvulsants effects in the neuromuscular transmission and its interaction with neuromuscular blocking, the results are contradictory [6][7][8][9][10][11][12][13][14][15] .…”
Section: Introductionmentioning
confidence: 99%