Doença celíaca em familiares de primeiro grau de portadores

Abstract

Objective: To determine the prevalence of celiac disease and to describe the histological alterations, clinical manifestations, and conditions associated with a group of first-degree relatives of celiac disease patients in the municipality of Recife, Northeast Brazil. Method:The study was conducted in outpatient clinics of pediatric gastroenterology located in Recife. We included in the study 174 first-degree relatives who were screened for the anti-transglutaminase IgA antibody. Those relatives who had positive serological tests were invited to undergo a small intestine biopsy (classified according to Marsh). They were also evaluated regarding weight, height, clinical symptoms and conditions associated with celiac disease. The chi-square test and Fisher's exact test were used to assess the differences with a significance level of p < 0.05. Results:The anti-transglutaminase IgA antibody was positive for 20.1% (34/174) of the relatives (95%CI 14.6-26.5). There was no difference in terms of positive serological tests regarding either degree of kinship or sex. Twenty-two patients underwent biopsy. Thirteen had histological alterations classified as Marsh stage 3; seven had stage 1; and two had stage zero, with a probable prevalence of 11.5%. All patients, except for one, had symptoms; the only patient with no symptoms was short. Conclusion:Celiac disease prevalence in this group of relatives was high. All new cases identified were symptomatic or had associated conditions. In this group, there was a high frequency of individuals with positive serological tests, symptoms suggestive of celiac disease, and no evidence of villous atrophy in the intestinal mucosa.J Pediatr (Rio J). 2010;86(4):331-336: Celiac disease, epidemiology, diagnosis, serology, pathology.

Nutritional status variation and intestinal and extra intestinal symptomatology in patients with celiac disease and non-celiac gluten sensitivity given specialized dietary advice

“…In Western countries celiac disease affects approximately 1.00% of the general population 6 . In Brazil official statistics on celiac disease epidemiology are unknown, but new studies show that celiac disease is found in 0.15 to 1.75% of the general population 7 . Additionally, first-degree relatives of celiacs share genetic and environmental risk factors for celiac disease and consequently, are 10 to 20 times more likely to develop the disease than the general population 7 .…”

Desenvolvimento de biscoito isento de glúten com recheio de manga (Mangifera indica L.) e enriquecido com ferro

“…A Doença Celíaca (DC) é uma doença que se caracteriza pela intolerância ao consumo do glúten e que além da predisposição genética, precisa de fatores imunológicos e ambientais para sua manifestação. É mais frequente em mulheres e indivíduos de cor branca, porém no Brasil há casos em mulatos devido à miscigenação [1][2][3][4].…”