Inadequação do consumo alimentar de crianças e adolescentes com artrite idiopática juvenil e lúpus eritematoso sistêmico

Caetano, Mauricio S.; Ortiz, Tania Yadhira Peña; Terreri, Maria Teresa; Sarni, Roseli Oselka Saccardo; Silva, Simone Guerra Lopes; Souza, Fabíola Isabel Suano de; Hilário, Maria Odete Esteves

doi:10.1590/s0021-75572009000600007

Cited by 33 publications

(9 citation statements)

References 13 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings are consistent with previous reports which showed no differences in nutrient intake between sero-negative poly-JIA and oligo-JIA subtypes, or between the children with active and inactive disease [24]; no association between fat intake and disease activity was found either [25]. Such results are not surprising as no intervention in diet nor n-3/n-6 PUFA supplementation was designed in this study, and both JIA and healthy children continued their regular daily diet.…”

Section: Discussionsupporting

confidence: 93%

The profile of polyunsaturated fatty acids in juvenile idiopathic arthritis and association with disease activity

et al. 2017

View full text Add to dashboard Cite

We investigated the association between dietary intake of n-3 and n-6 polyunsaturated fatty acids (PUFAs), serum profiles, and immune and inflammatory markers in juvenile idiopathic arthritis (JIA) in relation to onset, activity, and duration. A total of 66 JIA patients and 42 controls were included. Serum PUFA levels were assessed by gas-liquid chromatography-mass spectrometry, a dietary intake by 7-day dietary record method, and IL-6, IL-10, and IL-17A levels using ELISA. Dietary PUFA intake did not differ between the JIA group and controls. Intakes of n-6 and n-3 PUFA and serum levels were not associated. Levels of total n-6 PUFA and linoleic acid (LA) were higher in inactive JIA than in active JIA. Patients with active and short-lasting disease (less than 3 months from diagnosis) had significantly lower levels of arachidonic acid (AA) and docosahexaenoic acid (DHA) than the control. Serum α-linolenic acid (ALA) levels were significantly higher in poly-JIA than in oligo-JIA and in controls. We found significantly higher serum IL-10 levels in JIA than in controls. Serum n-6 and n-3 levels were significantly negatively correlated with active joint count, erythrocyte sedimentation rate, and C-reactive protein and positively with platelet count. Our study presents the low levels of AA and DHA in the active phase of short-lasting JIA, particularly poly-JIA, and the relationship between n-6 and n-3 PUFA and classic markers of inflammation. PUFAs may contribute to the pathogenesis of JIA and support a necessity to identify new targets suitable for successful interventional studies in JIA patients.

show abstract

Section: Discussionsupporting

confidence: 93%

The profile of polyunsaturated fatty acids in juvenile idiopathic arthritis and association with disease activity

et al. 2017

View full text Add to dashboard Cite

show abstract

“…This alarming rate is similar to the rates of obesity previously reported in otherwise healthy children, as well as in children with JIA [6-8]. …”

Section: Discussionsupporting

confidence: 88%

Obesity and disease activity in juvenile idiopathic arthritis

2012

View full text Add to dashboard Cite

BackgroundChildren with physical disabilities may have an increased risk for obesity and obesity might be a risk factor for inflammatory arthritis. The aims of this study were: to determine the prevalence of obesity in children and adolescents with juvenile idiopathic arthritis (JIA), and to examine the association between obesity and disease activity in this population.FindingsA cross-sectional analysis of all patients with JIA attending a pediatric rheumatology clinic, between October 2009 and September 2010, was performed. A linear regression model was used to explore the association between obesity and disease activity in patients with JIA. A total of 154 subjects were included in the analysis; median age was 10.6 years, 61% were female, and 88% were white. Obesity was found in 18%, 12% were overweight, and 3% were underweight. There was no association between obesity and JADAS-27 (Juvenile Arthritis Disease Activity Score 27), physician's assessment of disease activity, parent's assessment of child's well-being, erythrocyte sedimentation rate, number of active joints, or C-reactive protein (p-value range 0.10 to 0.95).ConclusionsAlthough 18% of patients with JIA were obese, we did not find an association between obesity and disease activity. As obesity confers an additional health risk in children with arthritis, addressing this co-morbidity should be a health priority in patients with JIA. Future studies are necessary to further explore potential associations between obesity, development of JIA, and disease activity.

show abstract

“…Some researchers draw attention to the fact that JIA patients exhibit impaired nutrition and lower BMI values compared to healthy children [ 27 , 28 ]. Factors associated with this fact are not clearly determined, and they may be associated with an inflammatory process, secreted cytokines, absorption disturbances, effects of medicines [ 29 ], inadequate dietary intake, and physical activity limitation [ 30 ]. Patients with systemic JIA have increased expenditure of energy [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Body Composition and Parameters of the Cardiovascular Risk in Juvenile Idiopathic Arthritis

Jednacz

Rutkowska-Sak

2015

BioMed Research International

View full text Add to dashboard Cite

The study was aimed to evaluate cardiovascular risk parameters, body mass index (BMI) centiles for sex and age, and body fat percentage using the electric bioimpedance method in children with juvenile idiopathic arthritis (JIA). 30 children with JIA participated in the study. A control group included 20 children. Patients were well matched for the age and sex. The body mass and body fat percentage were determined using the segmental body composition analyser; the BMI centiles were determined. All patients had the following parameters determined: lipid profile, hsCRP, homocysteine, and IL-6. The intima media thickness (IMT) was measured. Patients with JIA had significantly lower body weight, BMI, and the BMI centile compared to the control group. The IL-6 levels were significantly higher in patients with JIA compared to the control group. There were no differences between two groups with regard to the lipid profile, % content of the fat tissue, homocysteine levels, hsCRP, and IMT. Further studies are necessary to search for reasons for lower BMI and BMI centile in children with JIA and to attempt to answer the question of whether lower BMI increases the cardiovascular risk in these patients, similarly as in patients with rheumatoid arthritis (RA).

show abstract

Inadequação do consumo alimentar de crianças e adolescentes com artrite idiopática juvenil e lúpus eritematoso sistêmico

Cited by 33 publications

References 13 publications

The profile of polyunsaturated fatty acids in juvenile idiopathic arthritis and association with disease activity

The profile of polyunsaturated fatty acids in juvenile idiopathic arthritis and association with disease activity

Obesity and disease activity in juvenile idiopathic arthritis

Assessment of the Body Composition and Parameters of the Cardiovascular Risk in Juvenile Idiopathic Arthritis

Contact Info

Product

Resources

About