2007
DOI: 10.1590/s0021-75572007000500006
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Abstract: Objective: To assess the effect of phototherapy on serum oxidant and antioxidant status in hyperbilirubinemic full-term newborns.Method: Thirty-four full-term infants from 3 to 10 days of age exposed to phototherapy were studied. The serum antioxidant status was assessed by measuring the total antioxidant capacity (TAC) and individual antioxidant components: vitamin C, uric acid, albumin, thiol contents and total bilirubin. The oxidant status was assessed by determining the total oxidant status (TOS), oxidativ… Show more

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Cited by 9 publications
(6 citation statements)
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“…In supporting our findings, several studies demonstrated the genotoxic role of phototherapy in jaundiced neonates by using alkaline comet assay, SCE frequency, and micronucleus assay[5-11]. This effect is more likely due to the oxidative role of phototherapy[29,30]. In contrast to our results, Karakukcu et al .…”
Section: Discussionsupporting
confidence: 84%
See 1 more Smart Citation
“…In supporting our findings, several studies demonstrated the genotoxic role of phototherapy in jaundiced neonates by using alkaline comet assay, SCE frequency, and micronucleus assay[5-11]. This effect is more likely due to the oxidative role of phototherapy[29,30]. In contrast to our results, Karakukcu et al .…”
Section: Discussionsupporting
confidence: 84%
“…Although the repair process can theoretically decrease DNA damage after incubation[13], lower DNA repair and antioxidant capacities in neonates compared to adults should be taken into consideration[17,18]. In addition, it should be noted that the negative effects of phototherapy have previously been investigated on the antioxidant defense system in hyperbilirubinemic neonates[29]. …”
Section: Discussionmentioning
confidence: 99%
“…Serum TOS assay was calibrated with hydrogen peroxide (H 2 O 2 ) and the results were expressed in μmol H 2 O 2 equivalent/l (μmol H 2 O 2 equiv./Liter) [14] . As a reliable index of oxidative stress in the body, OSI was calculated as described in literature, and presented in arbitrary units [15] .…”
Section: Methodsmentioning
confidence: 99%
“…2005, Harma et al . 2005) and was calculated as follows: OSI (arbitrary unit)=((TOS, μmol H 2 O 2 equiv./l)/(TAS, μmol Trolox equiv./l)×100) (Aycicek & Erel 2007). …”
Section: Methodsmentioning
confidence: 99%