2012
DOI: 10.1590/s0004-282x2012000500005
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Abstract: Diabetic polyneuropathy can be confirmed by nerve conduction studies. The data can be analyzed in the form of a combined index instead of individual parameters. METHODS: The combined index included five parameters of nerve conduction studies commonly used for evaluation of polyneuropathies. We evaluated sensitivity in 100 diabetic patients with suspected polyneuropathy, and specificity in 200 non-diabetic patients with suspected lumbosacral radiculopathy. All results were expressed in number of standard deviat… Show more

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Cited by 7 publications
(18 citation statements)
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“…With the exception of "all measures," the best-performing Z-compounds consist mainly of measures from the lower extremities, which reflects the components identified by the PCA, and is in line with previous reports that the most sensitive measures can be found primarily in the legs and feet. 3,5,17 As one may expect from the relationship between number of NCS measures in the Z-compound and AI, shorter Z-compounds of four or fewer nerves did not perform well in the present study. Among the shorter Z-compounds, "Heise variant" 5 had the highest AI, surpassing some of the longer Z-compounds.…”
Section: Discussioncontrasting
confidence: 51%
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“…With the exception of "all measures," the best-performing Z-compounds consist mainly of measures from the lower extremities, which reflects the components identified by the PCA, and is in line with previous reports that the most sensitive measures can be found primarily in the legs and feet. 3,5,17 As one may expect from the relationship between number of NCS measures in the Z-compound and AI, shorter Z-compounds of four or fewer nerves did not perform well in the present study. Among the shorter Z-compounds, "Heise variant" 5 had the highest AI, surpassing some of the longer Z-compounds.…”
Section: Discussioncontrasting
confidence: 51%
“…An alternative approach, in which Z scores from several measures are combined (Z-compounds), has been shown to be more sensitive than single measures in diabetic polyneuropathy 3,4 without loss of specificity. 5 Recently, it has also been suggested that amplitudebased Z-compounds may be predictive of long-term nerve fiber loss and disability in chronic inflammatory demyelinating polyneuropathy. 6 Averaging many measures also eliminates statistical issues regarding multiple testing of several NCS variables, minimizes the effect of nonsystematic errors, and leads to low inter-and intrasubject variance.…”
Section: Introductionmentioning
confidence: 99%
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“…By combining normal deviates from several parameters into one average Z score, the number of tested variables is substantially reduced, random error is lessened, and test sensitivity may be increased. Previously, averaged Z scores have been used in nerve conduction studies (27) but not in autonomic function testing.…”
mentioning
confidence: 99%
“…The composite Z-scores are a summary parameter that can quantify the overall abnormality of NCVs. It has been demonstrated to have higher specificity and sensitivity for evaluating polyneuropathies than individual nerve MCV or SCV results ( 47 ). Our study found that each of the composite MCV, SCV, and MSCV Z-scores was independently and positively associated with total hip BMD T-score in male patients with T2DM, which shows the association between overall abnormality of NCV and total hip BMD decline.…”
Section: Discussionmentioning
confidence: 99%