Treatment of neuromyelitis optica: an evidence based review

Sato, Douglas Kazutoshi; Callegaro, Dagoberto; Lana-Peixoto, Marco Aurélio; Fujihara, Kazuo

doi:10.1590/s0004-282x2012000100012

Cited by 46 publications

(30 citation statements)

References 52 publications

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“…That is, the astrocyte is first damaged, followed by the oligodendrocyte and finally the axons(demyelination and neuronal loss). Aquaporin-4 antibody is positive in a high porcentaje of NMO patients and it is directed against this water channel richly expressed on foot processes of astrocytes [2,16]. Thereby, current NMO treatments include general immusuppressive agents, B-cell and plasma exchanges [6,32].…”

Section: Discussionmentioning

confidence: 99%

“…Neuromyelitis optica (NMO), also known as Devic´s disease, is a rare inflammatory disease of the central nervous system (CNS) characterized by severe optic neuritis and transverse myelitis, usually with a relapsing course [1][2][3]. Multiple sclerosis (MS) and NMO are autoinmune demyelinating diseases of the CNS, having distinct inmmunological and pathological features.…”

Section: Introductionmentioning

confidence: 99%

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Omental Transplantation for Neuromyelitis Optica

Rafael¹

2017

JNSK

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I report a 45-year old woman who had a history of neuromyelitis óptica (NMO). She was admitted by bilateral blindness and mydriasis, as well as tetraparesia. The visual evoked potential revealed absence of waves in both eyes. For this reason, she received an omental transplantation on the optic chiasm and left temporal lobe. Three days after surgery, she presented motor improvement in her limbs and later, she presented photophobia, photomotor reflex and to visualize silhouette of people and things. She died 8 days after surgery by bronchopneumonia. These results suggest that in the NMO there is an ischemic component in the optic chiasm and adjacent zones.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Omental Transplantation for Neuromyelitis Optica

Rafael¹

2017

JNSK

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“…For dem som ikke responderer på første-linjebehandling, vil mykofenolamofetil i opptrappende dosering til 1 g  2 vaere et godt alternativ (33,38,39). Annen potensielt effektiv behandling er metotreksat 15-25 mg per uke sammen med folat (33).…”

Section: Behandlingunclassified

Neuromyelitis optica

Kvistad¹,

Wergeland²,

Torkildsen³

et al. 2013

Tidsskriftet

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“…Although she had not been tested for NMO-IgG, our patient fulfilled the diagnostic criteria for neuromyelitis optica 2 . The patient underwent pulse therapy with methylprednisolone for five days 3 . Her visual deficit showed some improvement.…”

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confidence: 99%

Neuromyelitis optica of very late onset: one more case

Amorim

Rocha-Filho

2014

Arq. Neuro-Psiquiatr.

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Dear editors, We read with extreme interest the paper by Souza et al. 1 This study describes one case of a 75-year-old woman with neuromyelitis optica (NMO) 1. Including this case, only six cases of neuromyelitis optica developing after the age of 70 have been reported. We think that it is important to describe our recent experience.A 72-year-old Caucasian woman sought our service complaining of a rapidly progressive visual loss in the right eye. After a further week, the other eye was affected, culminating in complete bilateral blindness in less than 15 days. The patient also developed paraparesis, becoming paraplegic in this period. On physical examination she had a T4 sensory level associated with significant dysesthesia. Her magnetic resonance image showed lesions in three contiguous spinal cord levels (T2-T4) and absence of any brain lesions suggestive of multiple sclerosis. Computed tomography scans of the chest, abdomen and pelvis were normal. A CSF analysis showed a cell count of 11 cells/mm 3 (36% lymphocytes, 60% monocytes), glucose 75 mg% and proteins 68 mg%. Tests for syphilis, bacteria, fungi, herpes simplex, herpes zoster, cytomegalovirus, HTLV and HIV were negative. There were no oligoclonal bands. Serum assays on anti-DNA antibodies, anti-nuclear factor, anti-neutrophil cytoplasmic antibodies (p-ANCA and c-ANCA), anti-Ro (SSA), anti-La (SSB), anti-SM and rheumatoid factor, together with the serological test for the human immunodeficiency virus (HIV), were negative. Although she had not been tested for NMO-IgG, our patient fulfilled the diagnostic criteria for neuromyelitis optica 2 . The patient underwent pulse therapy with methylprednisolone for five days 3 . Her visual deficit showed some improvement. Immunoglobulin tests and plasmapheresis were not carried out owing to infectious complications that developed later. Our patient was released from the hospital with oral corticosteroids prescribed. Further evaluation is still necessary to establish whether the patient has shown any further improvement or relapses.

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Treatment of neuromyelitis optica: an evidence based review

Cited by 46 publications

References 52 publications

Omental Transplantation for Neuromyelitis Optica

Omental Transplantation for Neuromyelitis Optica

Neuromyelitis optica

Neuromyelitis optica of very late onset: one more case

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