Odors as triggering and worsening factors for migraine in men

Lima, Andressa Marmore de; Sapienza, Giovanna Baptista; Giraud, V; Fragoso, Yára Dadalti

doi:10.1590/s0004-282x2011000300011

Cited by 35 publications

(40 citation statements)

References 18 publications

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“…Several components of cigarette smoke, such as acrolein, crotonaldehyde [78], acetaldehyde [37] and nicotine [101], are TRPA1 agonists. Recently, acrolein application to the rat nasal mucosa has been shown to produce ipsilateral meningeal vasodilatation by a TRPA1- and CGRP-dependent mechanism [102], thus offering a mechanistic explanation for the association between the exposure to cigarette smoke and migraine attack appearance or worsening [103,104]. …”

Section: Reviewmentioning

confidence: 99%

TRPA1 and other TRP channels in migraine

et al. 2013

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Ever since their identification, interest in the role of transient receptor potential (TRP) channels in health and disease has steadily increased. Robust evidence has underlined the role of TRP channels expressed in a subset of primary sensory neurons of the trigeminal ganglion to promote, by neuronal excitation, nociceptive responses, allodynia and hyperalgesia. In particular, the TRP vanilloid 1 (TRPV1) and the TRP ankyrin 1 (TRPA1) are expressed in nociceptive neurons, which also express the sensory neuropeptides, tachykinins, and calcitonin gene-related peptide (CGRP), which mediate neurogenic inflammatory responses. Of interest, CGRP released from the trigeminovascular network of neurons is currently recognized as a main contributing mechanism of migraine attack. The ability of TRPA1 to sense and to be activated by an unprecedented series of exogenous and endogenous reactive molecules has now been extensively documented. Several of the TRPA1 activators are also known as triggers of migraine attack. Thus, TRP channels, and particularly TRPA1, may be proposed as novel pathways in migraine pathophysiology and as possible new targets for its treatment.

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Section: Reviewmentioning

confidence: 99%

TRPA1 and other TRP channels in migraine

et al. 2013

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“…Clinical reports have indicated that inhalation of TRPA1 irritants can trigger migraine headache with a high frequency in susceptible individuals [15,19,28,45,60]. Exposure to the scent of Umbellularia californica (aka “the headache tree”) can produce cluster-like headache attacks in humans [8] and the principal volatile component of the plant, umbellulone, was recently identified as a TRPA1 agonist [42,59].…”

Section: Introductionmentioning

confidence: 99%

Activation of TRPA1 on dural afferents: A potential mechanism of headache pain

Edelmayer

Yan

et al. 2012

Pain

116

139

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Activation of transient receptor potential ankyrin-1 (TRPA1) on meningeal nerve endings has been suggested to contribute to environmental irritant-induced headache but this channel may also contribute to other forms of headache such as migraine. The preclinical studies described here examined functional expression of TRPA1 on dural afferents and investigated whether activation of TRPA1 contributes to headache-like behaviors. Whole-cell patch-clamp recordings were performed in vitro using two TRPA1 agonists, mustard oil (MO) and the environmental irritant umbellulone (UMB), on dural-projecting trigeminal ganglion neurons. Application of MO and UMB to dural afferents produced TRPA1-like currents in approximately 42% and 38% of cells, respectively. Using an established in vivo behavioral model of migraine-related allodynia, dural application of MO and UMB produced robust time-related tactile facial and hindpaw allodynia that was attenuated by pretreatment with the TRPA1 antagonist HC-030031. Additionally, MO or UMB were applied to the dura and exploratory activity was monitored for 30 minutes using an automated open-field activity chamber. Dural MO and UMB decreased the number of vertical rearing episodes and the time spent rearing in comparison to vehicle treated animals. This change in activity was prevented in rats pretreated with HC-030031 as well as sumatriptan, a clinically effective anti-migraine agent. These data indicate that TRPA1 is expressed on a substantial fraction of dural afferents and activation of meningeal TRPA1 produces behaviors consistent with those seen in patients during migraine attacks. Further, they suggest that activation of meningeal TRPA1 via endogenous or exogenous mechanisms can lead to afferent signaling and headache.

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“…Therefore, distinguishing between enhanced sensitivity to smells in the early phase of the attack, before pain has started, and olfactory stimulation as a trigger is challenging [63]. In a study including 96 male migraineurs, Marmore de Lima et al found that odors, especially perfume, cigarette smoke and cleaning products, were the second most frequently reported trigger (48%) following stress (59%) [64]. Silva-Neto et al interviewed 400 headache patients, 200 with migraine and 200 with tension-type headache, regarding odorant substances as headache precipitant [65].…”

Section: Odorsmentioning

confidence: 99%

Migraine and Triggers: Post Hoc Ergo Propter Hoc?

Hoffmann

Recober

2013

Curr Pain Headache Rep

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The influence of environmental factors on the clinical manifestation of migraine has been a matter of extensive debate over the past decades. Migraineurs commonly report foods, alcohol, meteorologic or atmospheric changes, exposure to light, sounds, or odors, as factors that trigger or aggravate their migraine attacks. In the same way, physicians frequently follow this belief in their recommendations in how migraineurs may reduce their attack frequency, especially with regard to the consumption of certain food components. Interestingly, despite being such a common belief, most of the clinical studies have shown conflicting results. The aim of the review is to critically analyze clinical and pathophysiological facts that support or refute a correlation between certain environmental stimuli and the occurrence of migraine attacks. Given the substantial discrepancy between patients' reports and objective clinical data, the methodological difficulties of investigating the link between environmental factors and migraine are highlighted.

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Odors as triggering and worsening factors for migraine in men

Cited by 35 publications

References 18 publications

TRPA1 and other TRP channels in migraine

TRPA1 and other TRP channels in migraine

Activation of TRPA1 on dural afferents: A potential mechanism of headache pain

Migraine and Triggers: Post Hoc Ergo Propter Hoc?

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