Maintaining quality of life in multiple sclerosis: fact, fiction, or limited reality?

Vasconcelos, Alina Gomide; Haase, Vítor Geraldi; Lima, Eduardo de Paula; Lana-Peixoto, Marco Aurélio

doi:10.1590/s0004-282x2010000500010

Cited by 6 publications

(7 citation statements)

References 24 publications

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“…Cognitive problems, both the subjective experience of cognitive decline and objectively documented decline, are common among people with MS, and are associated with worse psychosocial and physical quality of life 47,48,27 . Although we expected fatigue to be the strongest predictor of daily outcomes, we did expect that days of slow or foggy thinking might be related to worse affective and functional outcomes.…”

Section: Discussionmentioning

confidence: 99%

How Do Pain, Fatigue, Depressive, and Cognitive Symptoms Relate to Well-Being and Social and Physical Functioning in the Daily Lives of Individuals With Multiple Sclerosis?

Kratz

Braley

Foxen‐Craft

et al. 2017

Archives of Physical Medicine and Rehabilitation

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Objective To examine the relative association between daily change in pain, fatigue, depressed mood, and cognitive function, and four outcomes (positive affect and well-being, ability to participate in social roles and activities, upper extremity (UE) functioning, and lower extremity (LE) functioning). Design Repeated-measures observational study including a baseline lab visit, followed by seven days of home monitoring that included ecological momentary assessment (EMA) of symptoms (pain, fatigue, depressed mood, and cognitive function) and end-of-day diary surveys of outcomes of interest. Multilevel mixed models were used to test study hypotheses. Setting General community. Participants Ambulatory adults (n=102) with MS recruited through [masked] and the surrounding community. Interventions Not applicable. Main Outcome Measure(s) Customized short-forms of the Neuro-QOL Positive Affect and Well-Being, Upper Extremity Functioning, and Lower Extremity Functioning item banks and the PROMIS Ability to Participate in Social Roles and Activity item banks, adapted for daily use and administered as end-of-day diaries. Results Above and beyond the effects of demographic and clinical covariates, daily pain was associated with three of the four outcomes; days of higher pain were related to lower same-day social participation (B=−1.00, p=0.002), UE functioning (B=−1.04, p=0.01), and LE functioning (B=−0.71, p=0.04). Daily fatigue and depressed mood were independently related to daily positive affect and well-being; days of worse fatigue (B=−0.54, p=0.006) and depressed mood (B=−1.17, p<0.0001) were related to lower same-day well-being. Conclusions Results demonstrate the role of fluctuations in symptoms in daily functioning and quality of life of individuals with MS. Daily increases in pain intensity are related to social and physical functioning, whereas increases in fatigue and depressed mood is related to daily lower levels of well-being. Findings implicate a person-centered approach to monitoring and treating symptoms.

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Section: Discussionmentioning

confidence: 99%

How Do Pain, Fatigue, Depressive, and Cognitive Symptoms Relate to Well-Being and Social and Physical Functioning in the Daily Lives of Individuals With Multiple Sclerosis?

Kratz

Braley

Foxen‐Craft

et al. 2017

Archives of Physical Medicine and Rehabilitation

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“…The results are in agreement with previous studies that have identified depression as the main predictor of HRQOL. 9 , 16 , 22 , 23 However, a smaller number of studies have also shown anxiety as another strong predictor for HRQOL. 5 , 24 Interestingly, the effect of depression and anxiety on physical as well as psychological subdomains were unequal, with depression having the stronger effect on all these subdomains, further suggesting the widespread negative effect of depression, and to a lesser extent anxiety, on multiple domains and accounting for its overall negative effect on the overall HRQOL in pwMS.…”

Section: Discussionmentioning

confidence: 99%

“… 8-10 To this effect, recent studies indicated the prevalence and incidence of depression and anxiety in pwMS, calling for improved screening, diagnosis and a more holistic patient care. 3-5 In most study findings, depression, along with other clinical symptoms such as fatigue, is found to be the strongest predictor of lower QOL in pwMS; 9 , 15 , 16 although some studies have found anxiety to be a more powerful predictor of QOL. 5 In general, such findings underscore the importance of recognizing comorbid psychiatric disorders in pwMS and call for the need to effectively screen and offer treatment options to these patients.…”

Section: Introductionmentioning

confidence: 93%

Depression and Anxiety as Determinants of Health-Related Quality of Life in Patients with Multiple Sclerosis - United Arab Emirates

Alsaadi¹,

Hammasi

Shahrour

et al. 2017

Neurology International

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To study the impact of depression and anxiety on health-related quality of life (HRQOL) in patients with multiple sclerosis (pwMS) in the UAE. All consecutive patients attending the MS clinic over a fourmonth period, October 2014 through February 2015, at Sheikh Khalifa Medical city (SKMC) were asked to complete The World Health Organization quality of life abbreviated scale (WHOQOL-BREF), the Patient Health Questionnaire nine-item (PHQ-9) depression scale, and Generalized Anxiety Disorder seven-item (GAD-7) scale. These last two scales were used to screen for depression and anxiety disorders respectively. The study looked at significant variables associated with HRQOL, using multivariate analysis. Eighty patients were enrolled in the study. Both anxiety and depression had a strong positive correlation with HRQOL in univariate analysis. However, depression was the strongest predictor of HRQOL in the patients using linear multi-regression analysis. Screening and timely treatment of both anxiety and depression in MS patients should be a recommended policy when managing pwMS to improve their optimal care and ensure better quality of life.

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“…(15,16) Fatigue is a common and debilitating symptom of MS, and often has a negative impact on quality of life. (17,18,19) In Brazil, the studies conducted in São Paulo, show prevalence rate of approximately 5/100,000, (20) is considered a low prevalence country. Women are committed more often and the symptoms usually appear between 20 and 40 years, with peak incidence around 30 years.…”

Section: Introductionmentioning

confidence: 99%

Classical massage in multiplesclerosis.

Santos¹,

Laurito²,

Silva³

et al. 2015

mtprehabjournal

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Background: Multiple sclerosis is an autoimmune disease, inflammatory that affects the white matter of the central nervous system, resulting in neurological signs and symptoms that after the outbreaks, may leave sequels as the location of the lesion. Symptoms may include loss of double vision, muscle weakness, lack of balance, numbness, pain, problem in the control of the bladder and bowel, fatigue, emotional changes and intellectual impairment. Objective: To describe the effects and compromise in carrier of multiple sclerosis, to check the efficiency of classical massage in reduction of symptoms and their influence on the performance of activities of daily living. Method/Design: It is a study of controlled clinical trial with a convenience sample of individuals already framed in clinical school of physical therapy at the University Nine July (Uninove). Eight were selected individuals diagnosed with Multiple Sclerosis, between 30 and 50 years of age, without dermatological problems for the application of classical massage. The subjects were evaluated before and after the proposed intervention consists of 20 sessions of classical massage performed twice a week having a duration of 40 minutes each session. Results: In the first three months, there have been significant results demonstrated the functional assessment (MIF), but from the sixth to the twelve months remained functional stability. The quality of life (SF-36) showed that in pre-requirements of General Condition, Vitality, Social, Emotional and Mental, was increased in the first nine months and after this period, the results were not significant. In the evaluation of the balance by the scale of Berg in the first three months did not show satisfactory results, but from the third month to the sixth month there was a significant increase in the balance. The sensitivity surface showed an increase after the sixth month of application of classical massage, keeping up to twelve months proposed by the study. In profound sensitivity presented significant results from nine months of treatment. Conclusions: The present study showed that the physical therapy, through the classical massage, does not eliminate the neurological damage that attends the disease, but can act in the treatment of specific symptoms favoring the well-being and the features of patients with multiple sclerosis.

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Maintaining quality of life in multiple sclerosis: fact, fiction, or limited reality?

Cited by 6 publications

References 24 publications

How Do Pain, Fatigue, Depressive, and Cognitive Symptoms Relate to Well-Being and Social and Physical Functioning in the Daily Lives of Individuals With Multiple Sclerosis?

How Do Pain, Fatigue, Depressive, and Cognitive Symptoms Relate to Well-Being and Social and Physical Functioning in the Daily Lives of Individuals With Multiple Sclerosis?

Depression and Anxiety as Determinants of Health-Related Quality of Life in Patients with Multiple Sclerosis - United Arab Emirates

Classical massage in multiplesclerosis.

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