Language brain dominance in patients with refractory temporal lobe epilepsy: a comparative study between functional magnetic resonance imaging and dichotic listening test

Fontoura, Denise Ren da; Branco, Daniel de Moraes; Anés, Maurício; Costa, Jaderson Costa da; Portuguez, Mirna Wetters

doi:10.1590/s0004-282x2008000100009

Cited by 11 publications

(4 citation statements)

References 21 publications

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“…[ 15 ] Some studies have shown that epileptic patients fail to show a right ear advantage on dichotic listening tasks. [ 16 17 ] Therefore, it could be hypothesized that auditory hallucinations may have a neuronal origin in the speech perception areas in the left temporal lobe and not unique for schizophrenia. Evidence of reduced gray matter density in temporal lobe areas in patients with temporal lobe epilepsy also suggests the neuronal origin of auditory hallucinations in epilepsy.…”

Section: Discussionmentioning

confidence: 99%

Psychiatric presentation of childhood epilepsy: Case series and review

2016

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Childhood-onset epilepsy has a varied presentation and may have different etiological factors. A multiaxial diagnostic approach should be used before making treatment and management decisions for any individual patient. It is widely accepted that distinction among primary psychiatric disorders, epilepsy, and nonepileptic seizures is a challenge for physicians. This case series demonstrated the identification of three atypical presentations of seizures in children on the basis of detailed history taking and electroencephalogram findings, despite having normal findings in neurological examination and magnetic resonance imaging. We report three rare cases of atypical presentation in epilepsy in patients with symptoms of episodic hallucinations, rage attacks, and secondary enuresis. Clinically, the diagnosis of epilepsy can be strengthened by paying sufficient attention to detailed history and symptom spectrum of partial epilepsy.

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Section: Discussionmentioning

confidence: 99%

Psychiatric presentation of childhood epilepsy: Case series and review

2016

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“…Only handedness was evaluated. However, a recent study (Fontoura et al, 2008 ) found that 92.3% of righthanded epilepsy patients with HS showed left-hemisphere language dominance (see also Springer et al, 1999 ). Loring et al ( 1999) observed that language transfer to the right hemisphere is more related to extensive lesions in areas beyond the temporal lobe.…”

Section: Participantsmentioning

confidence: 99%

Modulation of medial temporal lobe activity in epilepsy patients with hippocampal sclerosis during verbal working memory

Campo

Maestú

García‐Morales

et al. 2009

J Int Neuropsychol Soc

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It has been traditionally assumed that medial temporal lobe (MTL) is not required for working memory (WM). However, animal lesion and electrophysiological studies and human neuropsychological and neuroimaging studies have provided increasing evidences of a critical involvement of MTL in WM. Based on previous findings, the central aim of this study was to investigate the contribution of the MTL to verbal WM encoding. Here, we used magnetoencephalography (MEG) to compare the patterns of MTL activation of 9 epilepsy patients suffering from left hippocampal sclerosis with those of 10 healthy matched controls while they performed a verbal WM task. MEG recordings allow detailed tracking of the time course of MTL activation. We observed impaired WM performance associated with changes in the dynamics of MTL activity in epilepsy patients. Specifically, whereas patients showed decreased activity in damaged MTL, activity in the contralateral MTL was enhanced, an effect that became significant in the 600- to 700-ms interval after stimulus presentation. These findings strongly support the crucial contribution of MTL to verbal WM encoding and provide compelling evidence for the proposal that MTL contributes to both episodic memory and WM. Whether this pattern is signaling reorganization or a normal use of a damaged structure is discussed.

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“…Auditory hallucinations are also reported in epilepsy (e.g., Brasic & Perry, 1997). Epileptic patients also often fail to show a right ear advantage on dichotic listening tasks (e.g., Gramstad et al., 2003; Fontoura et al., 2008). Therefore, it could be hypothesized that hallucinating patients with epilepsy also should fail the dichotic listening test.…”

mentioning

confidence: 99%

An fMRI study of auditory hallucinations in patients with epilepsy

Korsnes¹,

Hugdahl²,

Nygård³

et al. 2010

Epilepsia

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SUMMARYPurpose: The aim of the study was to investigate behavioral and brain activation in nonpsychotic hallucinating individuals. Auditory hallucinations are reported by patients with epilepsy, although less frequent than visual hallucinations are. If behavioral and neuronal activation patterns in hallucinating patients with epilepsy are found to be similar to what has been found in hallucinating patients with schizophrenia, this would support a unique neuronal representation for auditory hallucinations cutting across diagnostic groups. Methods: We report behavioral and functional magnetic resonance imaging (fMRI) data from six epilepsy patients experiencing auditory hallucinations compared with six healthy control subjects. The participants had to report which of two simultaneously presented simple speech sounds they perceived on each trial, using a dichotic stimulus presentation mode. Results: The results showed that the patients failed to show an expected right ear advantage on the task, and they also showed significantly reduced activation in temporal, frontal, and cingulate cortex areas. Discussion: The results are discussed in relation to a view that neuropsychological and functional neuroimaging indices of auditory hallucinations may be orthogonal to diagnostic category and not unique to patients with schizophrenia.

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Language brain dominance in patients with refractory temporal lobe epilepsy: a comparative study between functional magnetic resonance imaging and dichotic listening test

Cited by 11 publications

References 21 publications

Psychiatric presentation of childhood epilepsy: Case series and review

Psychiatric presentation of childhood epilepsy: Case series and review

Modulation of medial temporal lobe activity in epilepsy patients with hippocampal sclerosis during verbal working memory

An fMRI study of auditory hallucinations in patients with epilepsy

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