Vasopressin serum levels and disorders of sodium and water balance in patients with severe brain injury

“…Lee et al recognized severe hypernatremia as an independent risk factor of mortality in the patients admitted to the neurosurgery intensive care unit [19]. Cintra et al reported a higher incidence of serum Na disturbance in patients who died in the first week after TBI compared to survivors [20]. The discrepancy between our findings and the results of mentioned studies may be due to the difference in the study population and duration of follow-up period; in our study, DAI patients were adult and all had consciousness levels below 15, while Yousefichaijan et al assessed 110 patients aged one month to 18 years.…”

Section: Discussionmentioning

confidence: 99%

Association Between Serum Electrolyte Disturbances and Glasgow Coma Scale Score in Patients With Diffuse Axonal Injury

Behzadnia¹,

Dibavand²,

Emamhadi³

et al. 2022

Caspian J Neurol Sci

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Background: Appropriate clinical measures to prevent secondary brain damage in traumatic brain injury are of critical importance. Objectives: This study aims to investigate the relationships between serum electrolyte disturbances and Glasgow Coma Scale (GCS) score in patients with Diffuse Axonal Injury (DAI) at the time of admission and discharge. Materials & Methods: In this retrospective cross-sectional study, we evaluated 101 patients with DAI having GCS score <15 admitted to Poursina Hospital in Rasht, Iran from 2019 to 2020. Based on the presence or absence of serum potassium (K), sodium (Na), magnesium (Mg), and zinc (Zn), disturbances on the first day of hospitalization, patients were divided into two study groups of with and without abnormal electrolyte levels. The GCS scores of the two groups at the time of admission and discharge were recorded and the relationship between electrolyte disturbances and GCS score was evaluated. Results: There were no significant differences in the mean GCS score at the time of admission and discharge between patients with and without disturbances in serum Na, K, Zn and Mg levels based on the crude analysis. Regarding the simultaneous effects of the study variables on the GCS score, only Mg serum level exerted a significant impact on the GCS score at the time of admission (P=0.041) and discharge (P=0.017). Conclusion: The GCS score in patients with DAI at the time of admission and discharge has an association with the Mg serum level but not with Na, K, and Zn levels.

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“…Plasma was frozen (-20°C) and sent to the laboratory on dry ice for peptide assay. ( 1 , 26 , 27 ) Atrial natriuretic factor was measured in duplicate by radioimmunoassay after the acetone-ether extraction of plasma.…”

Section: Methodsmentioning

confidence: 99%

Atrial natriuretic factor: is it responsible for hyponatremia and natriuresis in neurosurgery?

Gasparotto

Falcão

Kosour

et al. 2016

Revista Brasileira De Terapia Intensiva

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ObjectiveTo evaluate the presence of hyponatremia and natriuresis and their association with atrial natriuretic factor in neurosurgery patients.MethodsThe study included 30 patients who had been submitted to intracranial tumor resection and cerebral aneurism clipping. Both plasma and urinary sodium and plasma atrial natriuretic factor were measured during the preoperative and postoperative time periods.ResultsHyponatremia was present in 63.33% of the patients, particularly on the first postoperative day. Natriuresis was present in 93.33% of the patients, particularly on the second postoperative day. Plasma atrial natriuretic factor was increased in 92.60% of the patients in at least one of the postoperative days; however, there was no statistically significant association between the atrial natriuretic factor and plasma sodium and between the atrial natriuretic factor and urinary sodium.ConclusionHyponatremia and natriuresis were present in most patients after neurosurgery; however, the atrial natriuretic factor cannot be considered to be directly responsible for these alterations in neurosurgery patients. Other natriuretic factors are likely to be involved.

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Vasopressin serum levels and disorders of sodium and water balance in patients with severe brain injury

Abstract: AVP serum levels remained within the normal range values in these SBI patients, but those who died have shown higher incidence of abnormal sodium and water balance during the first week post-injury.

Cited by 8 publications

References 26 publications

Serum sodium: A useful prognostic factor for non-severe traumatic brain injury in children?

Serum sodium: A useful prognostic factor for non-severe traumatic brain injury in children?

Association Between Serum Electrolyte Disturbances and Glasgow Coma Scale Score in Patients With Diffuse Axonal Injury

Atrial natriuretic factor: is it responsible for hyponatremia and natriuresis in neurosurgery?

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