Neuromodulatory effects of caffeine and bromazepam on visual event-related potential (P300): a comparative study

Montenegro, Mariana; Veiga, Heloisa; Deslandes, Andréa Camaz; Cagy, Maurício; McDowell, Kaleb; Pompeu, Fernando; Piedade, Roberto; Ribeiro, Pedro

doi:10.1590/s0004-282x2005000300009

Cited by 11 publications

(6 citation statements)

References 19 publications

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“…The authors observed that the longest motor reaction time was noticed 6 hours after the drug ingestion. Montenegro 19 tried to verify whether there would be reaction time changes after ingestion of 3 mg of bromazepam. The authors believed that a longer reaction time would occur, but the expected result was not found.…”

Section: Discussionmentioning

confidence: 99%

The effects of bromazepam over the central and frontal areas during a motor task: an EEG study

Fortunato

Tanaka

Araújo

et al. 2015

Arq. Neuro-Psiquiatr.

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The present study investigates the influence of bromazepam while executing a motor task. Specifically, we intend to analyze the changes in alpha absolute power under two experimental conditions, bromazepam and placebo. We also included analyses of theta and beta frequencies. We collected electroencephalographic data before, during, and after motor task execution. We used a Two Way ANOVA to investigate the condition (PL × Br6 mg) and moment (pre and post) variables for the following electrodes: Fp1, Fp2, F7, F3, Fz, F4, F8, C3, CZ and C4. We found a main effect for condition on the electrodes FP1, F7, F3, Fz, F4, C3 and CZ, for alpha and beta bands. For beta band we also found a main effect for condition on the electrodes Fp2, F8 and C4; for theta band we identified a main effect for condition on C3, Cz and C4 electrodes. This finding suggests that the motor task did not have any influence on the electrocortical activity in alpha, and that the existing modifications were a consequence due merely to the drug use. Despite its anxiolytic and sedative action, bromazepam did not show any significant changes when the individuals executed a finger extension motor task.Keywords: bromazepam, electroencephalography, sensorimotor integration, absolute alpha power, motor task. RESUMOO presente estudo investiga a influência do bromazepam durante a execução de uma tarefa motora. Especificamente, pretende-se analisar as mudanças na potência absoluta de alfa sob duas condições experimentais, bromazepam e placebo. Nós também incluí-mos as analises das frequências teta e beta. Foram coletados dados eletroencefalográficos antes, durante e depois da execução da tarefa motora. Usamos uma Anova de 2 fatores para investigar a condição (PL × Br6 mg) e variáveis no momento (pré e pós) para os seguintes eletrodos: Fp1, Fp2, F7, F3, Fz, F4, F8, C3, C4 e CZ. Encontramos um efeito principal para a condição e eletrodos FP1, F7, F3, Fz, F4, C3 e CZ para alfa e beta. Para beta também foi encontrado um efeito principal para condição nos eletrodos Fp2, F8 e C4; para theta nós identificamos um efeito principal para condition em C3, Cz e C4. Este achado sugere que a tarefa motora não tem qualquer influência sobre a atividade eletrocortical alfa e que as modificações existentes foram uma consequência devido o uso de drogas. Apesar de sua ação ansiolítica e sedativa, o bromazepam não apresentou mudança significativa quando os indivíduos executaram uma tarefa motora.Palavras-chave: bromazepam, eletroencefalografia, integração sensório-motora, potência absoluta alfa.

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Section: Discussionmentioning

confidence: 99%

The effects of bromazepam over the central and frontal areas during a motor task: an EEG study

Fortunato

Tanaka

Araújo

et al. 2015

Arq. Neuro-Psiquiatr.

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, lower amplitude was observed for the caffeine condition, when compared to the normative database and bromazepam. Therefore, the authors stated that caffeine seemed to increase the P300 only when the individuals were tired [35]. Such results suggest that both the caffeine and the modafinil effects, with the utilized dose (200mg), do not improve the cognitive processes, evaluated by the P300 measures.…”

Section: Amplitudementioning

confidence: 98%

Effects of modafinil and bromazepam on decision-making: a P300 analysis

Novaes

Bittencourt²,

Adolfo³

et al. 2015

Int Arch Med

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Drug influence on the decision making process has been scarcely studied. Researchers have driven the hypothesis that drugs might cause interference on cortical circuits. The aim of the present study is to evaluate the electrophysiological and behavioral changes occurring in the P300 after ingestion of modafinil (200mg), bromazepam (6mg) and placebo in healthy subjects exposed to a sensorimotor task based on the oddball paradigm. The sample for this study consisted of 10 subjects of both sexes, with ages ranging between 20 and 45, who were submitted to a quantitative electroencephalography. The experimental procedure was carried out in three visits, before and after drug ingestion. The results demonstrated a significant increase in the P300 latency and amplitude for the target condition, when compared to the non-target condition, for all analyzed electrodes. No significant difference was found for group or moment. A statistically significant difference was found for the group variable in the behavioral analysis. Such results suggest that the P300 is a measure, which is not sensitive to drug ingestion. On the other hand, the measure presented certain level of sensitivity when the subjects faced two different conditions in the decision making process orientation.

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“…The preliminary phytochemical analysis of Limonia acidissima plant parts showed the presence of alkaloids, flavonoids, phenols, terpenoids, tannins,fats steroids, saponins, glycosides, gum, mucilage and fixed oils [15][16][17][18]…”

Section: Phytochemicalsmentioning

confidence: 99%

Antianxiety Effect of Ethanolic Extract of Fruits of Limonia Acidissima in Swiss Albino Mice

Vaishali¹,

Sandhya²,

Rajendra³

et al. 2021

IJPSM

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Anxiety disorder is one of the most common mental ailments exhibited by human. It is characterized by motor tension, sympathetic hyperactivity and apprehension and vigilance syndromes. A part from very few chemical remedies available like benzodiazepine and serotonin modulators, not much treatment options are at hand that safely and effectively alleviate anxiety. The ethanol extract of the fruits of plant Limonia acidissima was evaluated for its anti-anxiety activity in swiss albino mice at dose 200mg/kg and 400mg/kg body weight. Anti-anxiety was assessed by using elevated plus maze (EPM) and light and dark model methods. The ethanolic extract exhibit anxiolytic effect in experimental mice. So it is supports the use of Limonia acidissima as anxiolytic agents. Further investigation should be made to elucidate the active constituent of responsible for the activity.

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Neuromodulatory effects of caffeine and bromazepam on visual event-related potential (P300): a comparative study

Cited by 11 publications

References 19 publications

The effects of bromazepam over the central and frontal areas during a motor task: an EEG study

The effects of bromazepam over the central and frontal areas during a motor task: an EEG study

Effects of modafinil and bromazepam on decision-making: a P300 analysis

Antianxiety Effect of Ethanolic Extract of Fruits of Limonia Acidissima in Swiss Albino Mice

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