Peritoneal dissemination from central neurocytoma: case report

Neto, Maurício Coelho; Ramina, Ricardo; Meneses, Murilo S.; Arruda, Walter Oleschko; Milano, Jerônimo Buzetti

doi:10.1590/s0004-282x2003000600028

Cited by 18 publications

(5 citation statements)

References 31 publications

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“…Interestingly, like their CNS counterparts, the neurocytoma we report and that reported by Hirschowitz and colleagues both arose adjacent to an ependyma-lined cyst, mimicking the presence of a ventricle. A final diagnostic caveat is that there was one previous case report documenting a CNS central neurocytoma with peritoneal cavity dissemination (34); thus, the rare event of metastasis from a CNS primary should be kept in mind and excluded.…”

Section: Discussionmentioning

confidence: 99%

Primary Glial and Neuronal Tumors of the Ovary or Peritoneum

Liang

Olar

Niu

et al. 2016

American Journal of Surgical Pathology

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Primary glial and neuronal tumors of the ovary or peritoneum are rare neuroectodermal-type tumors similar to their counterparts in the central nervous system. We retrospectively reviewed 11 cases. These cases included 4 ependymomas, 6 astrocytic tumors and 1 neurocytoma. Patients’ age ranged from 9 to 50 years (mean, 26 years; median, 24 years). All ependymal tumors with detailed clinical history (n = 3) were not associated with any other ovarian neoplasm. In contrast, all astrocytic tumors were associated with immature teratoma (n = 4), mature cystic teratoma (n = 1) or mixed germ cell tumor (n = 1). The neurocytoma arose in association with mature teratomatous components in a patient with a history of treated mixed germ cell tumor. Immunohistochemical staining showed that 7 of 7 ependymal and astrocytic tumors (100%) were positive for glial fibrillary acidic protein, and 2 of 2 ependymomas (100%) were positive for both estrogen and progesterone receptors. The neurocytoma was positive for synaptophysin, and negative for S100 protein, glial fibrillary acidic protein and SALL4. No IDH1-R132H mutation was detected in 2 of 2 (0%) astrocytomas by immunohistochemistry. Next-generation sequencing was performed on additional 2 ependymomas and 2 astrocytomas, but detected no mutations in a panel of 50 genes that included IDH1, IDH2, TP53, PIK3CA, EGFR, BRAF and PTEN. Follow-up was available for 8 patients, with the follow-up period ranging from 4 to 59 months (mean, 15 months; median, 8.5 months), of which 3 had no evidence of disease and 5 were alive with disease. In conclusion, primary glial and neuronal tumors of the ovary can arise independently or in association with other ovarian germ cell tumor components. Pathologists should be aware of these rare tumors and differentiate them from other ovarian neoplasms. Even though an IDH1 or IDH2 mutation is found in the majority of WHO grade II and III astrocytomas, and in secondary glioblastomas arising from them, such mutations were not identified in our series, suggesting that these tumors are molecularly different from their CNS counterparts despite their morphologic and immunophenotypic similarities.

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Section: Discussionmentioning

confidence: 99%

Primary Glial and Neuronal Tumors of the Ovary or Peritoneum

Liang

Olar

Niu

et al. 2016

American Journal of Surgical Pathology

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“…The majority of them are located in the anterior half of the lateral ventricle. Hassoun and colleagues showed this to be the case in 98 of the 127 cases studied 6,7 .…”

Section: Discussionmentioning

confidence: 85%

“…Neuro c y t o m a can also be found into the fourth ventricle 3 , 4 and spinal cord 5 . This tumor can spread through cere b rospinal fluid and disseminate along craniospinal stru ct u re s 6 and organs outside central nervous system, such as the peritoneum by means of a ventriculoperitoneal shunt 7 . Neurocytoma localized outside the ventricular system is rarely found 8 .…”

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confidence: 99%

Central neurocytomas of uncommon locations: report of two cases

Gomes

França

Zymberg

et al. 2006

Arq. Neuro-Psiquiatr.

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-We re p o rt two patients with central neurocytomas at an uncommon location in the brain. The first, a 58-year-old man presenting with signs and symptoms of increased intracranial pre s s u re, had a tumor located at the pineal region. The second, a 21-year-old woman with tumor in the aqueductal region had worsening migraine-like headaches and diplopia. Both patients had obstructive hydrocephalus treated by n e u roendoscopic third ventriculostomy and biopsy of the tumors. No additional treatment was done. We conclude that neurocytomas should be considered in the diff e rential diagnosis of tumors located in the pineal and aqueductal regions.KEY WORDS: central neurocytoma, aqueductal region, pineal region, third ventriculostomy. Localizações incomuns do neurocitoma central: relato de dois casosRESUMO -Relatamos dois pacientes com neurocitoma central com localização incomum no sistema nervoso central. O primeiro, 58 anos, masculino, apresentava sinais e sintomas de hipertensão intracraniana, tinha um tumor na região da pineal. O segundo, feminino, 21 anos, tinha um tumor na região do aqueduto de Sylvius e apresentava cefaléia migranosa pro g ressiva e diplopia. Ambos apresentavam hidro c efalia obstrutiva tratada com terceiroventriculostomia endoscópica e biópsia da lesão. Não foi feito tratamento adicional. Concluimos que os neurocitomas devem ser considerados no diagnóstico diferencial de tumores localizados na região da pineal e do aqueduto. We re p o rt two patients with central neuro c y t o m a s at uncommon locations in the brain. In one patient the tumor was located in the aqueductal region and in the other the tumor laid in the pineal region. PALAVRAS-CHAVE CASESCase 1 -A 58-year-old man presented with a one-year h i s t o ry of memory loss, gait disturbance and headache. N e u rologic examination showed ataxic gait and papilledema. Computerized tomography images showed a hyperdense mass at the pineal region, with small points of calcification and moderate enhancement after contrast agent. Neither cysts nor invasion of the ventricular walls were seen. Lateral and third ventricles were dilated and showed periventricular edema, characterizing obstructive hydro c e p h alus. FLAIR and post-gadolinium T1-weighted MR images (Fig 1) revealed a mass with heterogeneous signal and moderate enhancement after paramagnetic agent, without

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“…She completed 5 cyclesPartial repsonse for a follow-up of 15 monthsBrandes et al [6]61 years old/maleLimited field radiation was completed with a partial response noted and stable disease for 5 years Recurrent disease developed and was treated with chemotherapy.Etoposide (40 mg/m 2 /day, Days 1-4), cisplatin (25 mg/m 2 /day, Days 1–4), and cytoxan (1000 mg/m 2 , Day 4) Cycles were repeated every 4 weeks. He completed 5 cyclesStable disease for a follow-up of 18 monthsBrandes et al [6]22 years old/femaleTotal resection was completed Recurrent disease 3 years later with ventrcular disease and a spinalEtoposide (40 mg /m 2 /day, Days cisplatin (25 mg/m 2 /day, Days 1–4), and cytoxan (1000 mg/m 2 , Day 4) Cycles were repeated every 4 weeks She completed 3 cyclesComplete response of the spinal lesion and stable ventricular disease Craniospinal radiation led to a complete response for a follow-up of 36 monthsCoelho et al [7]6 years old/maleRecurrent ventrile and thalamus and peritoneal dissemination 3 5 yrs after subtotal resection VP shunt for hydrocephalusEtoposide, carboplatin, doxorubicin, cyclophosphamideDied 3 days after diagnosis of disemminationDodds et al [8]15 years old/maleSubtotal resection completed along with placement of a VP shunt Treated with chemotherapyCarboplatin (500 mg/m 2 , Day 1–2), etoposide (100 mg/m 2 , Days 1–3), and ifosfamide (3 g/m 2 , Days 1–3) The etoposide and ifosfamide are repeated at week. 3 He completed 4 cyclesResponse with tumor shrinkage for 22 months until symptoms and tumor growth treated with subtotal resection and radiation therapy Stable disease with a follow-up period of 6 years.…”

Section: Discussionmentioning

confidence: 99%

Treatment of atypical central neurocytoma in a child with high dose chemotherapy and autologous stem cell rescue

et al. 2009

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The authors describe a 9 month old female with recurrent atypical central neurocytoma and leptomeningeal spread treated with high dose chemotherapy, autologous stem cell rescue, and adjuvant therapy. She had a complete response to therapy and was disease free at 4 years of age until a recurrence 6 months later. The use of intensive chemotherapy followed by autologous stem cell rescue for atypical neurocytoma may be considered as an adjunct to surgical therapy in young patients with atypical neurocytoma not amenable to radiation therapy.

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Peritoneal dissemination from central neurocytoma: case report

Cited by 18 publications

References 31 publications

Primary Glial and Neuronal Tumors of the Ovary or Peritoneum

Primary Glial and Neuronal Tumors of the Ovary or Peritoneum

Central neurocytomas of uncommon locations: report of two cases

Treatment of atypical central neurocytoma in a child with high dose chemotherapy and autologous stem cell rescue

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