Toxina botunílica tipo B no manejo de distonia não-responsiva a toxina botunílica tipo A

Cardoso, Francisco

doi:10.1590/s0004-282x2003000400015

Cited by 21 publications

(6 citation statements)

References 10 publications

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“…There were, however, differences in the complications caused by these two types of BoNT, xerostomia and dysphagia being significantly more common in patients receiving BoNT/B [ 62 ]. BoNT/B is effective and safe for treating CD, has similar potency to BoNT/A and can be used in patients who are refractory to treatment with the latter [ 76 , 77 , 78 , 79 , 80 ].…”

Section: Treatmentmentioning

confidence: 99%

Pain Relief in Cervical Dystonia with Botulinum Toxin Treatment

Camargo

Cattai

Teive

2015

Toxins

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Dystonia is a neurological disorder characterized by intermittent or sustained muscle contractions that cause abnormal, usually repetitive, movements and postures. Dystonic movements can be tremulous and twisting and often follow a pattern. They are frequently associated with overflow muscle activation and may be triggered or worsened by voluntary action. Most voluntary muscles can be affected and, in the case of the neck muscles, the condition is referred to as cervical dystonia (CD), the most common form of dystonia. The high incidence of pain distinguishes CD from other focal dystonias and contributes significantly to patient disability and low quality of life. Different degrees of pain in the cervical region are reported by more than 60% of patients, and pain intensity is directly related to disease severity. Botulinum toxin (BoNT) is currently considered the treatment of choice for CD and can lead to an improvement in pain and dystonic symptoms in up to 90% of patients. The results for BoNT/A and BoNT/B are similar. The complex relationship between pain and dystonia has resulted in a large number of studies and more comprehensive assessments of dystonic patients. When planning the application of BoNT, pain should be a key factor in the choice of muscles and doses. In conclusion, BoNT is highly effective in controlling pain, and its analgesic effect is sustained for a long time in most CD patients.

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Section: Treatmentmentioning

confidence: 99%

Pain Relief in Cervical Dystonia with Botulinum Toxin Treatment

Camargo

Cattai

Teive

2015

Toxins

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“…In a small open-label study of four patients, two patients with OMD (segmental dystonias) who became resistant to BTX-A were treated successfully with BTX-B (Rima-BoNT), suggesting that BTX-B injections are a safe and effective option for the management of OMD patients who become secondary nonresponders to BTX-A [19]. In a prospective observational study of 477 patients with focal dystonia, including 62 patients with OMD, patients were injected at the anterior temporalis, submental complex (digastric), pterygoid, and masseter.…”

Section: The Current State Of Evidencementioning

confidence: 99%

Chemodenervation for Oromandibular Dystonia Utilizing Botulinum Toxins

Ameer¹,

Bhatti²

2021

Cureus

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Oromandibular dystonia (OMD) is a chronic focal dystonia that involves the mouth, jaw, and tongue. It may cause repetitive or sustained dystonic movements, which can be very disabling for patients. It is usually a life-long disorder with numerous treatment options that are, most often, partially curative. In our experience, the best modality to treat OMD is botulinum toxin (BoNT) injections, which not only provide long-term relief but also have fewer adverse effects compared to other medications. Although multiple small-and large-scale studies support this fact, there is still a need for evidence from large randomized clinical trials. Jaw-closing dystonia responds very well to BoNT injections compared to other subtypes of OMD. This review discusses in detail the evidence, injection technique, and typical starting doses for botulinum injection.

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“…Entre os efeitos, com potenciais maléficos aos seres humanos, estão a paralisia muscular e a morte que são mediados pelos bloqueios da BoNT na liberação de ACh e subsequente parada na via de sinalização colinérgica nas junções sinápticas. 11 Outros sintomas relacionados a intoxicação BoNTs, podem variar xerose ocular e oral, tosse, retenção urinária, variações da pressão arterial, arritmias cardíacas, fadiga e dispneia 14 A cefaleia e as náuseas, até então associadas apenas ao quadro de ansiedade da paciente 10 , atualmente estão associadas a doses incorretas e a trauma no injetar, atingindo o periósteo 15 Outra preocupação crescente no meio médico é a formação de anticorpos. Apesar do uso clínico da BoNTA ser através da administração local, sua presença na corrente sanguínea tem sido relatada, através das técnicas de ELISA (enzyme-linked immunoabsorbent assay) ou RIA (radioimmunoassay).…”

Section: Revisão Das Complicaçõesunclassified

Revisão das Complicações da Utilização da Toxina Botulínica Full Face

Rodrigues

Franco²

2020

Arch. Health

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Introdução: A toxina botulínica (BoNT) é uma neurotoxina produzida pelo Clostridium botulinum,. Dentre os oito tipos de neurotoxinas, a do tipo A, sendo a mais utilizada. Entretanto, alguns riscos e possíveis complicações decorrentes do uso dessa substância podem acontecer Objetivo: Revisar a literatura abordando os eventos adversos decorrentes do uso da BoNT. Resultados: apesar de ser um procedimento considerado seguro e minimamente invasivo, a aplicação da BoNT pode causar algumas complicações leves a graves. Conclusão: É fundamental que os profissionais envolvidos neste procedimento, saibam reconhecer e intervir nas possíveis complicações.

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Toxina botunílica tipo B no manejo de distonia não-responsiva a toxina botunílica tipo A

Cited by 21 publications

References 10 publications

Pain Relief in Cervical Dystonia with Botulinum Toxin Treatment

Pain Relief in Cervical Dystonia with Botulinum Toxin Treatment

Chemodenervation for Oromandibular Dystonia Utilizing Botulinum Toxins

Revisão das Complicações da Utilização da Toxina Botulínica Full Face

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