2000
DOI: 10.1590/s0004-282x2000000600010
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Abstract: -The aim of present study was to evaluate the number and basophily of cell bodies of myenteric neurons in the ileum of rats with diabetes mellitus induced by streptozotocin. Four groups of rats were used: diabetes was induced in two (D) whereas the other two worked as controls (N). Animals were sacrificed six (6N, 6D) or nineteen (19N, 19D) weeks after diabetes induction. A segment of the terminal portion of the ileum of each rat was obtained and stained with Giemsa's solution, for whole-mount preparation stud… Show more

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Cited by 33 publications
(30 citation statements)
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“…The increase in the cellular size that follows denervation suggests that the extrinsic neural pulse has an inhibitory influence on the submucous nerves since, although the myenteric and the submucous plexus are spatially apart, they form an integrated unit 20 . Thus, the reduction of the inhibitory pulse by the neurons of the myenteric plexus, which are reduced in the chronic DM [21][22][23][24][25] for neurons in the submucous plexus, could result in an increase in the VIP production, increasing the area of the cell bodies of the submucous VIP-ergic neurons.…”
Section: Groupmentioning
confidence: 99%
“…The increase in the cellular size that follows denervation suggests that the extrinsic neural pulse has an inhibitory influence on the submucous nerves since, although the myenteric and the submucous plexus are spatially apart, they form an integrated unit 20 . Thus, the reduction of the inhibitory pulse by the neurons of the myenteric plexus, which are reduced in the chronic DM [21][22][23][24][25] for neurons in the submucous plexus, could result in an increase in the VIP production, increasing the area of the cell bodies of the submucous VIP-ergic neurons.…”
Section: Groupmentioning
confidence: 99%
“…He observed no response to histamine stimulation while the response to carbachol was enhanced in streptozotocin diabetic rats. The observed differences could possibly be connected to type of drug, the route of drug administration, rate of metabolism of the drug, metabolites produced (Zysset and Somer, 1986) and duration of diabetes induction (Hernandes et al, 2000).…”
Section: Discussionmentioning
confidence: 99%
“…A decrease in the number of myenteric neurons in STZ-induced diabetes in rats was observed in the stomach (Fregonesi et al 2001, Clebis et al 2004, in the duodenum (Romano et al 1996, Buttow et al 1997, Furlan et al 1999, in the ileum (Zanoni et al 2003, Alves et al 2006, in the small intestine as a whole (Hernandes et al 2000), in the cecum (Zanoni et al 2007), in the proximal colon (Furlan et al 2002). We can justify the controversial results for the NADPH-dp neurons in Group D, C, CS and DS when compared to other reports: the diabetes maintenance period as well as the neurochemical phenotype of the stained neurons was not similar.…”
Section: Discussionmentioning
confidence: 99%
“…We can justify the controversial results for the NADPH-dp neurons in Group D, C, CS and DS when compared to other reports: the diabetes maintenance period as well as the neurochemical phenotype of the stained neurons was not similar. Enhanced changes in the neuronal density can be better observed when a generalized neuronal population is stained regardless of their neurochemical phenotype, as occurs, for example, with the use techniques such as the cuprolinic blue (Phillips et al 2004), myosin V (Zanoni et al 2003), NADH-diaphorase (Sant'Ana et al 2001, Young et al 1993, Clebis et al 2004, , Zanoni et al 2007, Silva et al 2008, methylene blue (Hernandes et al 2000), among others, which stain the whole neuronal population, including the nitrergic neurons. When analyzing specific populations, such as NADPH-dp neurons, more specific results were obtained.…”
Section: Discussionmentioning
confidence: 99%