Cervical spine cord compression by eosinophilic granuloma: case report

Duarte-Silva, Elizabeth Batista; Noujaim, Jorge El-Kadum; Carnevale, Filomena

doi:10.1590/s0004-282x1999000300025

Cited by 5 publications

(5 citation statements)

References 18 publications

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“…26 Patients most often present with pain or torticollis; however, neurological deficits are uncommon. 10,24,26,45 Spinal cord or nerve root compression with subsequent weakness and numbness occurred in 4 patients in our series, 2 of whom required decompression for spinal cord compression and another 2 for unilateral weakness due to nerve root compression. Radiographically, lytic lesions are the most common, followed by partial or complete vertebral body collapse.…”

Section: Spinal Lchmentioning

confidence: 74%

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Craniospinal Langerhans cell histiocytosis in children: 30 years' experience at a single institution

Davidson

McComb²,

Bowen³

et al. 2008

PED

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Object The goal of this study was to review a large series of patients with Langerhans cell histiocytosis (LCH) who had craniospinal lesions to assess the long-term course, outcome, and efficacy of treatment of the disease. Methods Forty-four patients with LCH who presented to a single pediatric neurosurgical department between 1976 and 2006 were retrospectively reviewed. Results This series included 29 boys and 15 girls, ranging in age from 2 months to 13 years, with a mean follow-up duration of 4.5 years. Twenty-seven patients (61%) had unifocal bone lesions, 12 (27%) had multifocal bone disease, 2 (5%) had solitary hypothalamic–pituitary axis lesions, and 3 (7%) had multiple organ involvement at presentation. Five (19%) of the 27 patients with unifocal bone disease and 4 (33%) of the 12 patients with multifocal bone disease had delayed development of new bone lesions during the follow-up period. The time to development of new bone lesions ranged from 1 month to 1 year. Two of the 3 patients with multiple-organ LCH died. Patient age ≤ 2 years at the time of initial presentation was a risk factor for both initial multifocality and eventual dissemination. In all patients with initial multifocal bone involvement or later dissemination of unifocal bone disease, LCH was controlled by chemotherapy, except for 2 who were treated by surgery alone. Three patients had histological evidence of spontaneous resolution of their lesions. Conclusions Patients with unifocal LCH can be effectively treated with surgery alone. Very young patients are more likely to have multifocal disease and disseminations, and will usually require chemotherapy to control their disease. Spontaneously regressing lesions need not be resected; however, a biopsy procedure can be performed for diagnostic purposes.

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Section: Spinal Lchmentioning

confidence: 74%

“…The frequency of spinal involvement in patients with LCH is 6-25%. 10,24,26,55 Lesions predominantly involve the vertebral body, with only 5% of spine lesions involving the posterior elements. 26 Patients most often present with pain or torticollis; however, neurological deficits are uncommon.…”

Section: Spinal Lchmentioning

confidence: 99%

Craniospinal Langerhans cell histiocytosis in children: 30 years' experience at a single institution

Davidson

McComb²,

Bowen³

et al. 2008

PED

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“…5,6 Em 1999, Duarte-Silva et al relataram o sexto caso descrito em literatura de GE com compressão medular cervical. 7 A queixa mais comum do GE é a dor local e rigidez; 14 no entanto, os pacientes podem ser assintomáticos, podendo desenvolver os sintomas após traumas leves que impliquem fraturas patológicas. 6 Além disso, déficits sensitivos e/ou motores podem ocorrer.…”

Section: Discussionunclassified

“…6 Além disso, déficits sensitivos e/ou motores podem ocorrer. 7 Radiograficamente, a alteração mais precoce é a destruição do centro da vértebra. 4 Quando o colapso do corpo da vértebra progride para a aparência típica de vértebra plana com os discos intervertebrais intactos, o diagnóstico de GE é quase certo.…”

Section: Discussionunclassified

Granuloma eosinofílico da coluna vertebral cervical em criança

Faleiro¹,

Martins²,

Bicalho³

2012

Arq Bras Neurocir

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RESUMOGranuloma eosinofílico (GE) ABSTRACT Eosinophilic granuloma of the cervical spine in children Eosinophilic granuloma (EG) is a benign and more frequent form of Langerhans cell histiocytosis. Children and adolescent are mainly affected, being rare in adults. There is local proliferation of histiocytes in skull and long bones. Vertebral involvement is uncommon, especially at the cervical local. In this paper, we describe a case of a 7 years old child with EG in the cervical IntroduçãoTumores ósseos primários envolvendo a coluna vertebral em crianças são raros. Quando ocorrem, geralmente se enquadram nos seguintes subtipos: granuloma eosinofílico, cordoma, osteoma, sarcoma de Ewing, condrossarcoma mesenquimal, osteossarcoma, osteoblastoma, cisto ósseo aneurismático, displasia fibrosa, fibroma, angiossarcoma e hemangioma. 1 O granuloma eosinofílico (GE) ocorre em 6,5%-25% desses casos. 2,3 O GE representa 1% de todos os tumores ósseos. 4 Acomete a coluna vertebral em 7% dos casos, 4 sendo a região cervical menos afetada. 5,6 Trata-se de uma doença benigna que ocorre principalmente em crianças e integra aproximadamente 75% 7 de um espectro de doenças conhecido como histiocitose de células de Langerhans, que também engloba a doença de Hand-Schüller-Christian (HSC) e a doença de Letterer-Siwe (LS). Essas três doenças possuem padrão histopatológico em comum constituído por células de Langerhans e eosinófilos.A seguir, é descrito um caso de uma criança com GE na coluna vertebral cervical com compressão medular subjacente. Relato do casoPaciente de 7 anos, sexo masculino, natural de Nova Lima/MG, foi admitido com um histórico de quadro subagudo de cervicobraquialgia. Não havia histórico de trauma ou outras doenças. Procurou ortopedista, que prescreveu analgésicos e uso de colar cervical. Verificou--se melhora da irradiação, contudo houve persistência da dor cervical.

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“…Low-grade fever, elevated erythrocyte sedimentation rate, mild leukocytosis, and normochronic anemia are findings usually seen. Symptoms of spinal cord compression by eosinophilic granuloma are reported [29]. Eosinophilic granuloma is a rapidly growing lytic lesion of the vertebral body leading to progressive collapse (vertebra plana) with preservation of the adjacent disc space.…”

Section: Langerhans Cell Histiocytosismentioning

confidence: 99%

Imaging of primary bone tumors of the spine

Drevelegas

Chourmouzi²,

Boulogianni³

et al. 2003

European Radiology

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Primary tumors of the spine are relatively infrequent lesions compared with metastatic disease, multiple myeloma, and lymphoma. A wide variety of benign and malignant neoplasms can involve the spine. The imaging features of these lesions are often characteristic. We present an overview of the imaging modalities in primary tumors of the spine in order to provide a useful tool in current radiologic practice. The role of CT and MRI is discussed.

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Cervical spine cord compression by eosinophilic granuloma: case report

Cited by 5 publications

References 18 publications

Craniospinal Langerhans cell histiocytosis in children: 30 years' experience at a single institution

Craniospinal Langerhans cell histiocytosis in children: 30 years' experience at a single institution

Granuloma eosinofílico da coluna vertebral cervical em criança

Imaging of primary bone tumors of the spine

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