Meningencefalite a aspergillus

We report a fatal case of invasive pulmonary aspergillosis in a severely ill neonate and review 43 additional cases of invasive aspergillosis reported from 1955 through 1996 that occurred during the first 3 months of life. Eleven of the 44 patients had primary cutaneous aspergillosis, 10 had invasive pulmonary aspergillosis, and 14 had disseminated disease. Most infections were nosocomial in origin. Prematurity (43%); proven chronic granulomatous disease (14%); and a complex of diarrhea, dehydration, malnutrition, and invasive bacterial infections (23%) accounted for the majority of underlying conditions. At least 41% of the patients had received corticosteroid therapy before diagnosis, but only one patient had been neutropenic. Among patients who received medical and/or surgical treatment, outcome was relatively favorable, with an overall survival rate of 73%. Invasive aspergillosis may occur in neonates and young infants and warrants consideration under certain circumstances. Current therapeutic approaches consist of high-dose amphotericin B and appropriate surgical interventions.

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Invasive Pulmonary Aspergillosis in a Critically Ill Neonate: Case Report and Review of Invasive Aspergillosis During the First 3 Months of Life

Groll

Jaeger

Allendorf

et al. 1998

Clinical Infectious Diseases

108

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Actinomicose cerebral: observação anatomo-clinica e revisão da literatura brasileira

Queiróz

Nucci

Faria

1975

Arq. Neuro-Psiquiatr.

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Micoses do sistema nervoso central: dados anatomopatologicos da criptococose e aspergilose cerebrais

Queiroz

Martínez

1977

Arq. Neuro-Psiquiatr.

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The pathological findings of the cerebral involvement in deep-seated fungal infections in routine autopsy is reported. In 42 cases of mycotic infections studied among 3.966 autopsies, there were 8 cases of cryptococcosis and 2 of aspergillosis of the brain, showing a very low frequency of central nervous system involvement, occurring in a proportion of 1:400 autopsies. The histopathological findings of the brain in cases of cryptococcosis showed the spectrum of inflammatory reactions already described, although most of the cases presented with mild to severe meningitis with large number of giant cells, and slight degree of involvement of the nervous tissue. The cases of aspergillosis showed a pattern of severe necrotizing meningo-encephalitis with large number of fungi. The paper points out the role of the histological examination in the identification of the fungi in tissues and their morphologic reactions.

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Meningencefalite a aspergillus

Cited by 3 publications

References 1 publication

Invasive Pulmonary Aspergillosis in a Critically Ill Neonate: Case Report and Review of Invasive Aspergillosis During the First 3 Months of Life

Invasive Pulmonary Aspergillosis in a Critically Ill Neonate: Case Report and Review of Invasive Aspergillosis During the First 3 Months of Life

Actinomicose cerebral: observação anatomo-clinica e revisão da literatura brasileira

Micoses do sistema nervoso central: dados anatomopatologicos da criptococose e aspergilose cerebrais

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